| Duodenal Ulcer Haemorrhage |
Hospitalization |
11/26/2005 |
55 |
Female |
|
12/30/2005 |
Physician |
Japan |
|
| Gastric Ulcer Haemorrhage |
Hospitalization |
5/27/2005 |
48 |
Female |
|
12/30/2005 |
Physician |
Japan |
|
| Vomiting |
Hospitalization |
12/12/2005 |
49 |
Male |
257 lb |
1/17/2006 |
Physician |
United States |
|
| Vomiting |
Hospitalization |
12/22/2005 |
49 |
Male |
257 lb |
1/25/2006 |
Physician |
United States |
|
| Stress |
Hospitalization |
5/1/2005 |
48 |
Female |
91 lb |
2/2/2006 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Stress |
Hospitalization |
11/23/2005 |
55 |
Female |
101 lb |
2/1/2006 |
Physician |
Japan |
|
| Road Traffic Accident |
Other Serious |
3/25/2005 |
72 |
Female |
|
2/6/2006 |
Physician |
Japan |
|
| Post Procedural Complication |
Hospitalization |
9/1/2005 |
|
Male |
|
2/9/2006 |
Other Health Professional |
Canada |
|
| Myocardial Infarction |
Other Serious |
1/1/2001 |
59 |
Male |
220 lb |
2/21/2006 |
Lawyer |
United States |
|
| Viral Load Increased |
Other Serious |
11/1/2004 |
|
Male |
254 lb |
3/3/2006 |
Physician |
United States |
|
| Myoclonus |
Hospitalization |
1/17/2006 |
51 |
Male |
196 lb |
1/24/2006 |
Pharmacist |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Stress |
Hospitalization |
5/1/2005 |
48 |
Female |
91 lb |
3/10/2006 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Viral Load Increased |
Other Serious |
11/1/2004 |
|
Male |
254 lb |
3/21/2006 |
Physician |
United States |
|
| Small Intestinal Obstruction |
Hospitalization |
11/14/2005 |
58 |
Female |
81 lb |
3/17/2006 |
Physician |
Japan |
|
| Rhabdomyolysis |
Life Threatening |
4/11/2006 |
|
Male |
241 lb |
4/14/2006 |
Pharmacist |
United States |
|
| Vascular Pseudoaneurysm |
Other Serious |
1/1/2002 |
59 |
Male |
220 lb |
5/5/2006 |
Physician |
United States |
|
| Toe Amputation |
Required Intervention |
1/1/2006 |
74 |
Male |
|
5/30/2006 |
Physician |
United States |
|
| Skin Ulcer |
Required Intervention |
5/24/2006 |
74 |
Male |
|
5/30/2006 |
Physician |
United States |
|
| Aspartate Aminotransferase Increased |
Hospitalization |
6/4/2005 |
26 |
Female |
184 lb |
6/5/2006 |
|
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Sudden Death |
Death |
|
50 |
Male |
249 lb |
6/29/2006 |
Other Health Professional |
United Kingdom |
|
| Nervous System Disorder |
Other Serious |
6/25/2006 |
52 |
Male |
168 lb |
7/11/2006 |
Physician |
Japan |
|
| Toe Amputation |
Required Intervention |
1/1/2006 |
74 |
Male |
|
6/27/2006 |
Physician |
United States |
|
| Nervous System Disorder |
Other Serious |
6/25/2006 |
52 |
Male |
168 lb |
7/17/2006 |
Physician |
Japan |
|
| Ventricular Tachycardia |
Hospitalization |
|
52 |
Female |
132 lb |
7/13/2006 |
Pharmacist |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| International Normalised Ratio Increased |
Hospitalization |
6/14/2005 |
80 |
Male |
|
8/1/2006 |
Pharmacist |
United States |
|
| Therapeutic Response Decreased |
|
7/1/2005 |
|
Female |
|
8/8/2006 |
Other Health Professional |
United States |
|
| Oedema Peripheral |
Disability |
6/1/2006 |
|
Male |
198 lb |
9/6/2006 |
Physician |
Germany |
|
| Nervous System Disorder |
Other Serious |
6/25/2006 |
52 |
Male |
168 lb |
9/8/2006 |
Physician |
Japan |
|
| Oedema Peripheral |
Disability |
6/1/2006 |
|
Male |
198 lb |
9/19/2006 |
Physician |
Germany |
|
| White Blood Cell Count Increased |
Death |
5/5/2006 |
57 |
Male |
367 lb |
9/25/2006 |
Physician |
United States |
|
| Overdose |
Life Threatening |
7/22/2006 |
68 |
Female |
|
10/9/2006 |
Consumer |
France |
|
| Therapy Non-responder |
Hospitalization |
6/1/2006 |
76 |
Male |
|
10/9/2006 |
Physician |
United States |
|
| Tachycardia |
|
5/2/2006 |
51 |
Male |
|
10/24/2006 |
Other Health Professional |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Shock |
Death |
10/1/2006 |
67 |
Male |
117 lb |
11/7/2006 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Oedema Peripheral |
Disability |
6/1/2006 |
|
Male |
198 lb |
11/20/2006 |
Physician |
Germany |
|
| Therapeutic Response Decreased |
Other Serious |
11/26/2005 |
|
Female |
|
12/21/2006 |
Physician |
Italy |
|
| Shock |
Death |
10/1/2006 |
67 |
Male |
117 lb |
12/26/2006 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Restlessness |
Hospitalization |
1/2/2007 |
29 |
Female |
93 lb |
2/22/2007 |
Physician |
Japan |
|
| Parvovirus B19 Serology Positive |
Other Serious |
10/5/2006 |
|
Male |
161 lb |
3/9/2007 |
Physician |
United States |
|
| Therapeutic Response Decreased |
Other Serious |
11/26/2005 |
|
Female |
|
3/9/2007 |
Physician |
Italy |
|
| Overdose |
Hospitalization |
1/29/2007 |
68 |
Male |
139 lb |
3/14/2007 |
Physician |
France |
|
| Parvovirus B19 Serology Positive |
Other Serious |
10/5/2006 |
|
Male |
161 lb |
3/19/2007 |
Physician |
United States |
|
| Tremor |
Hospitalization |
7/4/2005 |
53 |
Female |
|
3/21/2007 |
Pharmacist |
Japan |
|
| Therapeutic Response Decreased |
Other Serious |
11/26/2005 |
|
Female |
|
3/29/2007 |
Physician |
Italy |
|
| Therapeutic Response Decreased |
Other Serious |
11/26/2005 |
|
Female |
|
4/4/2007 |
Physician |
Italy |
|
| Leukocytosis |
Other Serious |
2/1/2007 |
|
Male |
181 lb |
4/12/2007 |
Physician |
United States |
|
| Rash Erythematous |
|
8/1/2004 |
58 |
Male |
|
4/17/2007 |
Other Health Professional |
United States |
|
| Vomiting |
Hospitalization |
2/17/2007 |
72 |
Male |
|
4/17/2007 |
Pharmacist |
Japan |
|
| Tremor |
Other Serious |
8/1/2006 |
79 |
Male |
157 lb |
5/5/2007 |
Physician |
United States |
|
| Leukocytosis |
Other Serious |
2/1/2007 |
|
Male |
181 lb |
5/29/2007 |
Physician |
United States |
|
| Nephrogenic Fibrosing Dermopathy |
Other Serious |
12/1/2002 |
75 |
Male |
201 lb |
5/25/2007 |
Physician |
United States |
|
| Overdose |
Hospitalization |
1/29/2007 |
68 |
Male |
139 lb |
6/22/2007 |
Physician |
France |
|
| Nephrogenic Fibrosing Dermopathy |
Other Serious |
6/1/2002 |
82 |
Male |
|
6/26/2007 |
Physician |
United States |
|
| Nephrogenic Fibrosing Dermopathy |
Death |
|
15 |
Male |
77 lb |
6/27/2007 |
Consumer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Paraesthesia |
Other Serious |
|
40 |
Male |
|
7/3/2007 |
Physician |
France |
|
| Tremor |
Hospitalization |
7/4/2005 |
53 |
Female |
|
7/6/2007 |
Pharmacist |
Japan |
|
| Therapeutic Response Decreased |
Other Serious |
11/26/2005 |
|
Female |
|
7/12/2007 |
Physician |
Italy |
|
| Hepatic Cirrhosis |
Death |
|
70 |
Female |
|
7/26/2007 |
|
United States |
|
| Peritonitis |
Life Threatening |
10/7/2006 |
72 |
Female |
78 lb |
7/20/2007 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Blood Creatine Phosphokinase Increased |
Other Serious |
1/1/2007 |
64 |
Male |
143 lb |
8/10/2007 |
Physician |
Japan |
|
| Large Intestine Perforation |
Life Threatening |
10/7/2006 |
72 |
Female |
78 lb |
8/13/2007 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Peritonitis |
Life Threatening |
10/7/2006 |
72 |
Female |
78 lb |
8/23/2007 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Blood Creatine Phosphokinase Increased |
Other Serious |
1/1/2007 |
64 |
Male |
143 lb |
8/30/2007 |
Physician |
Japan |
|
| Renal Failure Chronic |
Other Serious |
1/1/2007 |
63 |
Male |
143 lb |
9/6/2007 |
Physician |
Japan |
|
| Incorrect Dose Administered |
|
1/1/2007 |
|
Male |
|
9/7/2007 |
Physician |
France |
|
| Nephrogenic Systemic Fibrosis |
Death |
1/1/2004 |
15 |
Male |
77 lb |
9/26/2007 |
Consumer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Nephrogenic Systemic Fibrosis |
Other Serious |
12/1/2002 |
75 |
Male |
201 lb |
10/8/2007 |
Physician |
United States |
|
| Nephrogenic Systemic Fibrosis |
Other Serious |
6/1/2002 |
82 |
Male |
|
10/8/2007 |
Physician |
United States |
|
| Proteinuria |
Death |
1/9/2007 |
|
Female |
235 lb |
11/7/2007 |
Physician |
United Kingdom |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Upper Respiratory Tract Infection |
Hospitalization |
3/1/2007 |
60 |
Male |
|
11/5/2007 |
Physician |
Japan |
|
| Renal Failure Chronic |
Other Serious |
7/24/2007 |
63 |
Male |
143 lb |
11/13/2007 |
Physician |
Japan |
|
| Procedural Complication |
|
2/27/2007 |
51 |
Female |
|
11/21/2007 |
|
France |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Proteinuria |
Death |
1/9/2007 |
|
Female |
235 lb |
12/3/2007 |
Physician |
United Kingdom |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| White Blood Cell Count Decreased |
Other Serious |
1/1/2007 |
67 |
Male |
|
12/7/2007 |
|
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Endotracheal Intubation Complication |
Life Threatening |
10/3/2007 |
|
Female |
165 lb |
12/5/2007 |
Pharmacist |
United States |
|
| Retinal Detachment |
Hospitalization |
1/1/2006 |
68 |
Female |
|
12/4/2007 |
Other Health Professional |
Germany |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Myalgia |
Hospitalization |
11/28/2007 |
|
Female |
|
12/12/2007 |
Other Health Professional |
Netherlands |
|
| Therapeutic Response Decreased |
|
4/7/2007 |
|
Female |
|
12/15/2007 |
Other Health Professional |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Atrial Flutter |
Other Serious |
10/22/2007 |
61 |
Male |
305 lb |
1/16/2008 |
Consumer |
United States |
|
| Renal Failure Chronic |
Hospitalization |
7/24/2007 |
63 |
Male |
143 lb |
2/1/2008 |
Physician |
Japan |
|
| Diarrhoea |
Hospitalization |
12/29/2007 |
56 |
Female |
209 lb |
2/1/2008 |
|
United States |
|
| Cerebrovascular Accident |
Hospitalization |
12/5/2007 |
64 |
Male |
|
1/31/2008 |
Pharmacist |
Canada |
|
| Myalgia |
Hospitalization |
11/28/2007 |
|
Female |
|
2/8/2008 |
Other Health Professional |
Netherlands |
|
| Vomiting |
|
12/1/2007 |
70 |
Female |
225 lb |
2/17/2008 |
|
United States |
|
| Diarrhoea |
Hospitalization |
12/29/2007 |
56 |
Female |
209 lb |
2/27/2008 |
Consumer |
United States |
|
| Peritonitis |
Hospitalization |
12/18/2007 |
46 |
Male |
|
3/3/2008 |
Physician |
Japan |
|
| Peritonitis |
Hospitalization |
12/18/2007 |
46 |
Male |
|
3/3/2008 |
Physician |
Japan |
|
| Vomiting |
Hospitalization |
1/1/2008 |
60 |
Male |
|
3/31/2008 |
Other Health Professional |
United States |
|
| Unevaluable Event |
|
3/3/2008 |
41 |
Male |
|
3/28/2008 |
Consumer |
United States |
|
| Haemoglobin Decreased |
Life Threatening |
2/22/2008 |
57 |
Male |
|
3/28/2008 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Nausea |
|
3/3/2008 |
41 |
Male |
|
4/2/2008 |
Consumer |
United States |
|
| Swollen Tongue |
Life Threatening |
10/3/2007 |
|
Female |
155 lb |
4/8/2008 |
Pharmacist |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Vomiting |
Hospitalization |
1/1/2008 |
60 |
Male |
|
4/11/2008 |
Other Health Professional |
United States |
|
| Procedural Complication |
Life Threatening |
2/22/2008 |
57 |
Male |
|
4/18/2008 |
Physician |
Japan |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Nephrogenic Systemic Fibrosis |
Other Serious |
1/1/2004 |
15 |
Male |
77 lb |
4/29/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Renal Failure Chronic |
Other Serious |
3/3/2008 |
41 |
Male |
|
4/30/2008 |
|
United States |
|
| Nephrogenic Systemic Fibrosis |
Other Serious |
1/1/2004 |
15 |
Male |
77 lb |
5/5/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Renal Failure Acute |
Hospitalization |
2/1/2008 |
83 |
Female |
176 lb |
5/12/2008 |
Consumer |
Netherlands |
|
| Leukocytosis |
Other Serious |
2/1/2007 |
|
Male |
181 lb |
5/19/2008 |
Physician |
United States |
|
| Vomiting |
|
12/1/2007 |
70 |
Female |
225 lb |
5/27/2008 |
Other Health Professional |
United States |
|
| Vomiting |
|
12/1/2007 |
70 |
Female |
226 lb |
6/3/2008 |
Other Health Professional |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Low Turnover Osteopathy |
Other Serious |
3/3/2008 |
|
Female |
|
6/6/2008 |
Physician |
Belgium |
|
| Renal Transplant |
Other Serious |
3/3/2008 |
41 |
Male |
|
6/13/2008 |
Other Health Professional |
United States |
|
| Fatigue |
|
1/1/2006 |
63 |
Male |
|
4/10/2008 |
Consumer |
United States |
|
| Xerosis |
Other Serious |
1/1/2000 |
11 |
Male |
77 lb |
6/19/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Xerosis |
Other Serious |
1/1/2000 |
11 |
Male |
77 lb |
6/23/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Myelitis Transverse |
Hospitalization |
7/7/2006 |
|
Male |
200 lb |
7/25/2008 |
Physician |
United States |
|
| Hypocalcaemia |
Other Serious |
2/25/2008 |
|
Female |
|
8/4/2008 |
Physician |
Belgium |
|
| Proteinuria |
Death |
1/9/2007 |
|
Female |
235 lb |
8/4/2008 |
Physician |
United Kingdom |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Renal Failure Acute |
Other Serious |
8/1/2007 |
|
Male |
|
8/11/2008 |
Physician |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| White Blood Cell Count Decreased |
Other Serious |
1/1/2007 |
|
Male |
|
8/11/2008 |
|
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Proteinuria |
Other Serious |
1/1/2007 |
|
Female |
235 lb |
9/2/2008 |
Physician |
United Kingdom |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Renal Failure |
Other Serious |
2/6/2008 |
51 |
Male |
|
9/17/2008 |
Lawyer |
United States |
|
| Rash |
Hospitalization |
8/1/2008 |
70 |
Female |
|
10/15/2008 |
Consumer |
France |
|
| Myelodysplastic Syndrome |
Other Serious |
9/6/2008 |
|
Male |
|
10/17/2008 |
Other Health Professional |
United States |
|
| Skin Tightness |
Other Serious |
11/1/2006 |
51 |
Female |
141 lb |
10/29/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Skin Tightness |
Other Serious |
11/1/2006 |
51 |
Female |
141 lb |
10/30/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Renal Cancer |
Other Serious |
1/1/2005 |
66 |
Male |
|
11/4/2008 |
Other Health Professional |
United States |
|
| Myelodysplastic Syndrome |
Other Serious |
9/6/2008 |
|
Male |
|
11/6/2008 |
Other Health Professional |
United States |
|
| Skin Tightness |
Other Serious |
11/1/2006 |
51 |
Female |
141 lb |
11/20/2008 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Myelodysplastic Syndrome |
Other Serious |
9/6/2008 |
|
Male |
|
12/4/2008 |
Other Health Professional |
United States |
|
| Vomiting |
Hospitalization |
1/1/2008 |
|
Female |
|
11/3/2008 |
Other Health Professional |
United States |
|
| Peritonitis Bacterial |
Other Serious |
10/12/2007 |
73 |
Female |
190 lb |
11/3/2008 |
|
United States |
|
| Xerosis |
Other Serious |
1/1/2000 |
11 |
Male |
77 lb |
12/3/2008 |
|
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Xerosis |
Other Serious |
1/1/2000 |
11 |
Male |
77 lb |
12/3/2008 |
|
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Parvovirus B19 Serology Positive |
Other Serious |
10/5/2006 |
|
Male |
161 lb |
1/23/2009 |
Physician |
United States |
|
| Swelling |
Other Serious |
1/28/2008 |
63 |
Female |
209 lb |
1/30/2009 |
Lawyer |
United States |
|
| Vomiting |
Other Serious |
12/1/2007 |
70 |
Female |
225 lb |
1/30/2009 |
Other Health Professional |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Proteinuria |
Other Serious |
1/1/2007 |
|
Female |
235 lb |
2/5/2009 |
Physician |
United Kingdom |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Cellulitis |
Other Serious |
1/7/2009 |
|
Male |
304 lb |
2/20/2009 |
Physician |
United States |
|
| Swelling |
Other Serious |
1/28/2008 |
63 |
Female |
209 lb |
2/24/2009 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Skin Ulcer |
Death |
10/1/2007 |
66 |
Female |
254 lb |
2/24/2009 |
Physician |
United States |
|
| Haemoglobin Decreased |
Other Serious |
|
|
Female |
|
2/26/2009 |
Other Health Professional |
United States |
|
| Swelling |
Other Serious |
1/28/2008 |
63 |
Female |
209 lb |
3/6/2009 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Tendon Disorder |
Other Serious |
1/1/2005 |
72 |
Female |
139 lb |
3/9/2009 |
Physician |
United States |
|
| Sepsis |
Other Serious |
1/27/2009 |
|
Male |
181 lb |
3/16/2009 |
|
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Sensation Of Heaviness |
Required Intervention |
2/20/2009 |
59 |
Female |
280 lb |
3/17/2009 |
Pharmacist |
United States |
|
| Tendon Disorder |
Other Serious |
1/1/2005 |
72 |
Female |
139 lb |
3/26/2009 |
Physician |
United States |
|
| Tendon Disorder |
Other Serious |
1/1/2005 |
72 |
Female |
139 lb |
3/31/2009 |
Physician |
United States |
|
| Parathyroid Tumour Benign |
Other Serious |
12/16/2008 |
53 |
Male |
|
4/2/2009 |
Physician |
Germany |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Pulmonary Hypertension |
Other Serious |
4/1/2009 |
61 |
Male |
|
4/23/2009 |
Other Health Professional |
United States |
|
| Parathyroid Tumour Benign |
Other Serious |
12/16/2008 |
53 |
Male |
|
4/28/2009 |
Physician |
Germany |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Tachycardia |
Other Serious |
1/7/2009 |
|
Male |
304 lb |
4/30/2009 |
Physician |
United States |
|
| Skin Tightness |
Other Serious |
1/1/2006 |
54 |
Male |
335 lb |
5/12/2009 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Skin Tightness |
Other Serious |
1/1/2006 |
54 |
Male |
335 lb |
5/13/2009 |
Lawyer |
United States |
| Primary |
|
| Secondary |
|
| Concomitant |
|
|
| Pyrexia |
Hospitalization |
3/1/2009 |
59 |
Male |
|
5/14/2009 |
Other Health Professional |
United States |
|
| Tachycardia |
Other Serious |
1/7/2009 |
|
Male |
304 lb |
5/19/2009 |
Physician |
United States |
|
| Vomiting |
Death |
1/7/2000 |
60 |
Male |
157 lb |
5/26/2009 |
Lawyer |
United States |
|
| Vomiting |
Death |
1/7/2000 |
60 |
Male |
157 lb |
5/26/2009 |
Lawyer |
United States |
|
| Vomiting |
Death |
1/7/2000 |
60 |
Male |
157 lb |
5/28/2009 |
Lawyer |
United States |
|