Allopurinol combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pyrexia Other Serious 11/26/2005 66 Female 128 lb 12/30/2005 Switzerland
Primary
Secondary
Concomitant
Productive Cough Other Serious 10/18/2004 Male 183 lb 1/13/2006 United States
Primary
Secondary
Rib Fracture Hospitalization 9/15/2005 Male 245 lb 1/19/2006 Physician United Kingdom
Primary
Concomitant
Respiratory Syncytial Virus Infection Other Serious 12/16/2005 Male 160 lb 1/13/2006 United States
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Hospitalization 11/12/2004 69 Male 181 lb 1/17/2006 Physician France
Primary
Secondary
Concomitant
Renal Failure Required Intervention 8/25/2005 61 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Required Intervention 10/29/2005 40 Female 11/15/2005 Other Health Professional United States
Primary
Concomitant
Viral Pharyngitis Other Serious 1/1/2000 51 Male 231 lb 1/27/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 8/17/2004 Female 132 lb 1/17/2006 United States
Primary
Secondary
Renal Failure Hospitalization 8/25/2005 61 Male 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 1/31/2006 Male 194 lb 2/8/2006 Other Health Professional United States
Primary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/23/2006 Physician United States
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 1/31/2006 Male 194 lb 2/28/2006 Physician United States
Primary
Secondary
Concomitant
Retinal Artery Occlusion Other Serious 4/1/2002 81 Female 2/15/2006
Primary
Secondary
Concomitant
Viral Pharyngitis Other Serious 1/1/2000 51 Male 231 lb 3/1/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Tract Infection Other Serious 1/1/2005 Male 3/3/2006 Physician Canada
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 11/10/2004 68 Male 152 lb 3/7/2006 Physician Japan
Primary
Secondary
Concomitant
Viral Pharyngitis Other Serious 1/1/2000 51 Male 231 lb 3/21/2006 Physician United States
Primary
Secondary
Concomitant
Swelling 12/1/2005 Male 252 lb 3/24/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 3/24/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 3/28/2006 Physician France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 3/28/2006 Consumer France
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 1/13/2006 71 Male 137 lb 4/3/2006 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 9/15/2005 Male 245 lb 4/11/2006 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 2/1/2006 Male 4/20/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Life Threatening 2/4/2006 40 Female 209 lb 4/13/2006 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 2/7/2006 40 Female 209 lb 4/14/2006 Physician France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2000 51 Male 231 lb 5/9/2006 Physician United States
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/4/2006 40 Female 209 lb 5/8/2006 Physician France
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 11/20/2003 66 Male 209 lb 5/18/2006 Lawyer United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/2006 40 Female 5/19/2006 Consumer Japan
Primary
Secondary
Concomitant
Septic Shock Life Threatening 2/7/2006 40 Female 209 lb 5/15/2006 Physician France
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 5/15/2006 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/22/2003 61 Male 95 lb 5/16/2006 Physician Japan
Primary
Secondary
Concomitant
Calculus Bladder Hospitalization 3/1/2004 Male 177 lb 6/9/2006 Physician United States
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 10/1/2003 Female 294 lb 6/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Disability 1/1/2004 61 Female 98 lb 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Skin Nodule Hospitalization 10/1/2003 Female 119 lb 6/22/2006 Germany
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2/22/2006 69 Male 7/11/2006 Pharmacist Canada
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2/22/2006 69 Male 7/11/2006 Pharmacist Canada
Primary
Concomitant
Pustular Psoriasis Other Serious 3/14/2006 57 Male 187 lb 7/20/2006 Physician France
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2/22/2006 69 Male 7/14/2006 Pharmacist Canada
Primary
Concomitant
Pericarditis Constrictive Hospitalization 10/1/2003 Female 119 lb 7/20/2006 Germany
Primary
Concomitant
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary
Throat Tightness Other Serious 1/1/2004 Male 270 lb 8/18/2006 Consumer United States
Primary
Concomitant
Rash Maculo-papular Other Serious 3/14/2006 57 Male 187 lb 8/24/2006 Physician France
Primary
Concomitant
Blood Glucose Increased 6/20/2006 67 Female 152 lb 7/21/2006 Consumer United States
Primary
Concomitant
Chest Discomfort Disability 2/16/2006 43 Female 8/30/2006 Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2006 72 Female 9/10/2006 Consumer United States
Primary
Concomitant
Tuberculosis Hospitalization 8/25/2006 60 Male 9/29/2006 Physician Belgium
Primary
Concomitant
Throat Tightness Other Serious 1/1/2004 Male 270 lb 10/5/2006 Physician United States
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 1/1/2004 Male 272 lb 10/9/2006 Physician United States
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 1/1/2004 Male 272 lb 10/13/2006 Physician United States
Primary
Concomitant
Neck Pain Other Serious 64 Male 201 lb 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Neck Pain Other Serious 64 Male 201 lb 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Death 12/1/2003 Female 10/31/2006 Physician United States
Primary
Concomitant
Intestinal Ischaemia Other Serious 9/11/2006 77 Male 11/2/2006 Other Health Professional Canada
Primary
Concomitant
Renal Failure Life Threatening 1/28/2005 54 Female 106 lb 11/9/2006 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 7/16/2006 Female 227 lb 11/14/2006 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 7/16/2006 Female 227 lb 11/14/2006 Physician Germany
Primary
Concomitant
Bladder Cancer Other Serious 11/1/2006 Female 182 lb 11/20/2006 Physician United States
Primary
Concomitant
Retroperitoneal Neoplasm Life Threatening 1/28/2005 54 Female 106 lb 11/20/2006 Physician Japan
Primary
Concomitant
Localised Infection Other Serious 1/1/2006 81 Female 12/6/2006 Physician Sweden
Primary
Concomitant
Prostate Cancer Hospitalization 7/19/2006 Male 12/7/2006 Physician Belgium
Primary
Concomitant
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2003 Female 12/13/2006 Physician United States
Primary
Concomitant
Sinusitis 3/1/2006 Female 12/13/2006 Consumer United States
Primary
Concomitant
Localised Infection Other Serious 4/1/2006 81 Female 12/18/2006 Physician Sweden
Primary
Concomitant
Ureteral Neoplasm Other Serious 11/1/2006 Female 182 lb 12/18/2006 Physician United States
Primary
Concomitant
Panic Attack 7/26/2006 Female 12/18/2006 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 8/30/2006 Male 176 lb 12/22/2006 Physician France
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 6/9/2006 Female 179 lb 12/27/2006 Physician United States
Primary
Secondary
Concomitant
Sleep Apnoea Syndrome Hospitalization 8/17/2006 Female 3/9/2007 Physician United States
Primary
Concomitant
Nausea 12/17/2006 Female 3/27/2007 Consumer United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 4/12/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Interaction Other Serious 2/22/2007 14 Male 62 lb 5/2/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Heart Rate Irregular Other Serious 4/1/2007 Male 5/16/2007 Physician United States
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/15/2007 59 Male 234 lb 5/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 6/8/2007 Physician Italy
Primary
Concomitant
Hyperkeratosis Other Serious 9/12/2006 74 Male 163 lb 6/17/2007 Physician France
Primary
Secondary
Concomitant
Syncope Other Serious 5/14/2007 76 Female 6/15/2007 Canada
Primary
Concomitant
Vomiting Other Serious 12/25/2004 Female 110 lb 6/25/2007 Consumer United States
Primary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 7/5/2007 Physician Italy
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
Osteoarthritis Hospitalization 6/22/2007 Female 229 lb 7/5/2007 United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
White Blood Cell Count Decreased Death 2/4/2006 80 Male 8/31/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Renal Failure Other Serious 3/1/2007 Male 161 lb 9/5/2007 Germany
Primary
Secondary
Concomitant
Right Ventricular Failure Other Serious 3/1/2007 Male 161 lb 9/21/2007 Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 21 Female 8/16/2007 Physician United States
Primary
Secondary
Sepsis Neonatal Hospitalization Male 8/16/2007 Physician United States
Primary
Secondary
Lung Neoplasm Malignant Other Serious 83 Female 10/18/2007 Physician United States
Primary
Concomitant
Right Ventricular Failure Other Serious 3/1/2007 Male 161 lb 10/22/2007 Germany
Primary
Secondary
Concomitant
Deep Vein Thrombosis Other Serious 9/26/2007 Male 10/26/2007 Physician Australia
Primary
Concomitant
Renal Failure Other Serious 1/1/2007 Male 204 lb 11/2/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Other Serious 10/18/2007 Female 94 lb 11/7/2007 Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 1/1/2004 Male 11/8/2007 Other Health Professional Portugal
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 3/1/2007 Male 11/9/2007 Physician Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 10/14/2006 11 Female 60 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Axonal Neuropathy Other Serious 1/1/2007 Male 154 lb 11/21/2007 Physician France
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 9 Male 11/21/2007 Sweden
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 8/1/2006 Female 12/7/2007 Physician
Primary
Concomitant
Skin Ulcer Other Serious 3/28/2007 29 Male 163 lb 12/14/2007 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Adverse Event 1/1/2007 Male 220 lb 12/14/2007 Consumer United States
Primary
Concomitant
Staphylococcal Infection 4/1/2007 Female 250 lb 12/14/2007 Consumer United States
Primary
Concomitant
Vomiting Other Serious 12/25/2004 Female 110 lb 1/15/2008 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/17/2008 Physician United States
Primary
Secondary
Concomitant
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 12/17/2007 69 Male 1/23/2008 Consumer United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 9/24/2007 46 Female 146 lb 1/24/2008 United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 60 Female 1/25/2008 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/25/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Right Ventricular Failure Other Serious 3/1/2007 Male 161 lb 2/8/2008 Germany
Primary
Secondary
Concomitant
Metastasis Other Serious 1/24/2008 Male 218 lb 2/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 2/12/2008 Physician United States
Primary
Secondary
Concomitant
Prostate Cancer Other Serious 10/1/2007 59 Male 276 lb 2/14/2008 Physician Germany
Primary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 2/14/2008 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 1/1/2007 Female 174 lb 2/14/2008 Other Health Professional Germany
Primary
Concomitant
Right Ventricular Failure Other Serious 3/1/2007 Male 161 lb 2/20/2008 Germany
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 2/5/2008 3 Male 29 lb 2/26/2008 Other Health Professional Canada
Primary
Concomitant
Urinary Tract Infection Other Serious 3/1/2007 Male 161 lb 3/18/2008 Germany
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 13 Male 128 lb 3/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Renal Failure Acute Hospitalization 6/15/2006 70 Male 3/21/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Movement Disorder Hospitalization 1/9/2008 13 Male 128 lb 3/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 3/1/2007 Male 161 lb 3/24/2008 Germany
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 3/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 13 Male 3/18/2008 United Kingdom
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 13 Male 128 lb 3/20/2008 United Kingdom
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 13 Male 128 lb 3/27/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Respiratory Failure Other Serious 12/27/2007 58 Male 3/28/2008 Physician France
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 13 Male 128 lb 3/31/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Aspergillosis Death 1/20/2008 Male 4/2/2008 Physician France
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/9/2008 13 Male 128 lb 4/2/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Muscular Weakness Hospitalization 1/9/2008 4/7/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Movement Disorder Hospitalization 1/9/2008 13 Male 128 lb 4/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 1/14/2008 13 Male 4/2/2008 United Kingdom
Primary
Secondary
Concomitant
Portal Vein Thrombosis Hospitalization 11/10/2006 69 Male 4/2/2008 Japan
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 1/1/2008 Male 4/10/2008 Other Health Professional France
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/9/2008 13 Male 128 lb 4/4/2008 United Kingdom
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/15/2006 Female 201 lb 4/16/2008 Physician Italy
Primary
Concomitant
Death Other Serious Male 218 lb 4/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Wound Sepsis Hospitalization 2/28/2008 Male 170 lb 4/25/2008 Consumer United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization 2/29/2008 Male 170 lb 5/2/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 5/6/2008 Physician United States
Primary
Secondary
Concomitant

Drug Data