Allopurinol combined with Hydroxyurea

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Swelling Hospitalization 4/1/2005 Male 175 lb 2/1/2006 Consumer United States
Primary
Concomitant
Vomiting Other Serious 46 Male 2/3/2006 Consumer Australia
Primary
Concomitant
Toxic Epidermal Necrolysis Death 74 Male 2/13/2006 Canada
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 3/9/2006 59 Male 137 lb Other Health Professional United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 4/4/2002 78 Male 139 lb 3/16/2006 United States
Primary
Concomitant
Tachycardia Other Serious 4/8/2003 50 Male 243 lb 3/17/2006 United States
Primary
Concomitant
Thrombosis Other Serious 10/6/2005 64 Female 203 lb 4/21/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 74 Male 4/28/2006 Canada
Primary
Secondary
Concomitant
Petechiae Required Intervention 4/18/2006 80 Female 176 lb 5/1/2006 Physician United States
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 45 Male 6/9/2006 Physician Croatia (Local Name: Hrvatska)
Primary
Concomitant
Cardiac Failure Other Serious 9/1/2005 75 Male 190 lb 5/3/2006 Physician Germany
Primary
Concomitant
Cardiac Failure Other Serious 9/1/2005 75 Male 190 lb 7/14/2006 Physician Germany
Primary
Concomitant
Headache 9/1/2005 84 Female 95 lb 8/1/2006 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 10/6/2005 64 Female 203 lb 7/27/2006 Germany
Primary
Secondary
Concomitant
Tachycardia Other Serious 4/8/2003 50 Male 243 lb 8/21/2006 United States
Primary
Concomitant
Tumour Lysis Syndrome Hospitalization 4/4/2002 78 Male 139 lb 8/28/2006 United States
Primary
Concomitant
Renal Impairment Death 7/1/2006 72 Male 185 lb 8/29/2006 Physician United States
Primary
Concomitant
Septic Shock Death 64 Female 9/7/2006 Poland
Primary
Concomitant
Tenderness Life Threatening 7/11/2006 75 Male 9/6/2006 Pharmacist United States
Primary
Concomitant
Vascular Calcification Life Threatening 10/15/2005 67 Male 183 lb 9/8/2006 United States
Primary
Concomitant
Swollen Tongue Other Serious 9/1/2006 88 Female 9/21/2006 United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 8/27/2004 64 Female 10/2/2006 Poland
Primary
Concomitant
Vascular Calcification Life Threatening 10/15/2005 67 Male 183 lb 9/28/2006 United States
Primary
Concomitant
Thrombosis Other Serious 10/6/2005 64 Female 203 lb 10/9/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Blister Hospitalization 8/26/2006 70 Male 11/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tricuspid Valve Incompetence Required Intervention 11/2/2006 64 Male 11/16/2006 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 74 Male 5/3/2007 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
No Therapeutic Response Other Serious 2/1/2007 22 Male 176 lb 5/5/2007 Pharmacist United Kingdom
Primary
Concomitant
Rash 3/12/2007 72 Male 184 lb 5/6/2007 Other Health Professional United States
Primary
Concomitant
Tachycardia Hospitalization 5/24/2007 55 Male 150 lb 8/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/1/2007 73 Male 174 lb 8/27/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 7/1/2007 73 Male 174 lb 9/21/2007 Physician United States
Primary
Concomitant
Skin Turgor Decreased Hospitalization 2/11/2007 82 Female 9/26/2007 Other Health Professional United States
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 9/23/2007 Male 192 lb 10/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Other Serious 1/7/2004 Female 202 lb 10/12/2007 Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 43 Male 10/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Tumour Lysis Syndrome Other Serious 43 Male 10/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Pneumothorax Other Serious 2/19/2007 72 Male 11/13/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Life Threatening 10/7/2007 14 Male 203 lb 11/8/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/14/2007 43 Female 249 lb 11/19/2007 Other Health Professional Italy
Primary
Concomitant
Wound Haemorrhage Hospitalization 11/17/2007 24 Male 121 lb 11/28/2007 Physician Taiwan, Province Of China
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 74 Male 11/22/2007 Taiwan, Province Of China
Primary
Concomitant
Skin Turgor Decreased Hospitalization 2/11/2007 82 Female 11/28/2007 Other Health Professional United States
Primary
Concomitant
Wound Haemorrhage Hospitalization 11/17/2007 24 Male 121 lb 12/4/2007 Physician Taiwan, Province Of China
Primary
Concomitant
Serratia Infection Life Threatening 10/14/2007 43 Female 249 lb 12/5/2007 Other Health Professional Italy
Primary
Concomitant
Ventricular Fibrillation Other Serious 10/14/2007 43 Female 249 lb 12/7/2007 Other Health Professional Italy
Primary
Concomitant
Supraventricular Extrasystoles Required Intervention 3/13/2007 70 Female 1/24/2008 Other Health Professional United States
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 2/2/2006 66 Male 4/13/2008 Other Health Professional
Primary
Concomitant
Vomiting Hospitalization 3/17/2008 71 Female 152 lb 5/14/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/17/2006 71 Female 152 lb 5/15/2008 Physician United States
Primary
Secondary
Concomitant
Nephropathy Toxic Hospitalization 12/6/2007 33 Male 193 lb 6/22/2008 Pharmacist United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 5/21/2003 58 Male 6/27/2008 United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 5/13/2008 44 Male 192 lb 7/10/2008 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/17/2008 71 Female 152 lb 7/21/2008 Physician United States
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 1/1/2008 63 Female 141 lb 8/9/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 5/21/2003 58 Male 8/13/2008 Physician United Kingdom
Primary
Concomitant
Angioedema Other Serious 10/4/2007 68 Male 9/2/2008 Austria
Primary
Concomitant
Vomiting Hospitalization 3/17/2008 71 Female 152 lb 8/26/2008 Physician United States
Primary
Secondary
Concomitant
Pericardial Effusion Hospitalization 9/8/2008 79 Female 141 lb 9/19/2008 United States
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 2/19/2007 73 Male 9/29/2008 Other Health Professional Denmark
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/17/2008 71 Female 152 lb 9/29/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/29/2008 71 Female 152 lb 9/29/2008 Physician United States
Primary
Secondary
Concomitant
Pericardial Effusion Hospitalization 9/8/2008 79 Female 141 lb 10/10/2008 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 10/30/2008 62 Male 142 lb 11/3/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Status Epilepticus Required Intervention 3/13/2007 70 Female 11/7/2008 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 7/10/2008 85 Male 176 lb 11/25/2008 Other Health Professional Austria
Primary
Concomitant
Ureteric Dilatation Other Serious 56 Male 231 lb 12/10/2008 Other Health Professional Spain
Primary
Concomitant
Pneumonia Fungal Hospitalization 9/8/2008 79 Female 141 lb 12/3/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Product Quality Issue Other Serious 2/28/2008 83 Female 12/19/2008 Consumer United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 11/19/2008 60 Female 152 lb 12/29/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Other Serious 1/1/2003 79 Female 180 lb 12/23/2008 Consumer United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 81 Male 181 lb 12/23/2008 Physician Italy
Primary
Secondary
Concomitant
Optic Neuritis Other Serious 12/19/2008 37 Male 1/7/2009 Other Health Professional Spain
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 45 Male 2/5/2009 Other Health Professional Australia
Primary
Concomitant
Respiratory Failure Hospitalization 10/9/2008 75 Male 2/20/2009 Consumer Switzerland
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 12/3/2008 55 Male 158 lb 2/24/2009 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Death 45 Male 3/13/2009 Other Health Professional Australia
Primary
Concomitant
Respiratory Failure Hospitalization 3/13/2009 Male 143 lb 3/31/2009 Belgium
Primary
Concomitant
Throat Tightness Other Serious 8/31/2008 Male 177 lb 9/9/2008 Consumer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 3/12/2007 Male 219 lb 4/27/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/18/2009 69 Male 5/8/2009 Physician Japan
Primary
Concomitant
Respiratory Failure Hospitalization 3/13/2009 Male 143 lb 5/14/2009 Belgium
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/9/2009 69 Male 5/26/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/14/2009 69 Male 5/29/2009 Physician Japan
Primary
Concomitant
Pain In Extremity Other Serious 4/5/2009 81 Male 179 lb 6/2/2009 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/14/2009 69 Male 6/4/2009 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 7/1/2008 60 Female 6/11/2009 Other Health Professional Germany
Primary
Concomitant
Vomiting Other Serious 4/14/2009 57 Male 146 lb 6/16/2009 Physician Japan
Primary
Secondary
Concomitant
Unresponsive To Stimuli Required Intervention 5/19/2009 41 Male 170 lb 6/4/2009 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 3/12/2007 Male 219 lb 7/16/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/14/2009 68 Male 7/16/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/14/2009 68 Male 7/30/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 3/1/2009 Female 145 lb 8/14/2009 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/17/2009 Male 163 lb 8/26/2009 Physician Germany
Primary
Concomitant
Neutropenic Sepsis Hospitalization 1/1/2009 Male 9/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 1/1/2009 Male 9/10/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Life Threatening 11/13/2008 Male 9/4/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 7/12/2009 Male 9/21/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Medication Error Hospitalization 55 Male 10/2/2009 Other Health Professional Colombia
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/14/2009 68 Male 10/8/2009 Physician Japan
Primary
Secondary
Concomitant
Refusal Of Treatment By Patient Other Serious 11/27/2007 49 Male 189 lb 10/5/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/6/2009 59 Female 10/14/2009 Korea, Republic Of
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 74 Male 10/26/2009 Pharmacist Canada
Primary
Secondary
Concomitant
Urticaria Other Serious 1/1/2008 Male 11/2/2009 Physician United States
Primary
Concomitant
Interacting
Vomiting Other Serious 11/1/2009 33 Male 11/12/2009 Consumer Germany
Primary
Secondary
Acute Myeloid Leukaemia Death 9/30/2009 Female 114 lb 11/19/2009 United States
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/1/1995 Male 205 lb 12/2/2009 Other Health Professional United States
Primary
Concomitant
Influenza Other Serious 5/1/2009 Male 12/4/2009 Canada
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Life Threatening 11/13/2008 Male 12/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/14/2009 Female 102 lb 12/21/2009 Physician Korea, Republic Of
Primary
Concomitant
Myelofibrosis Disability 11/12/2009 63 Female 129 lb 12/22/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 4/14/2009 57 Male 146 lb 1/5/2010 Physician Japan
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Life Threatening 11/13/2008 Male 139 lb 1/22/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/14/2009 Female 102 lb 1/27/2010 Physician Korea, Republic Of
Primary
Concomitant
Thrombocytopenia Hospitalization 1/14/2009 Female 102 lb 2/3/2010 Physician Korea, Republic Of
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 11/13/2008 69 Male 139 lb 2/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 12/31/2007 66 Male 2/8/2010 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Viral Infection Other Serious 1/1/1995 Male 205 lb 3/4/2010 Other Health Professional United States
Primary
Concomitant
Wheezing Other Serious 2/17/2010 65 Female 3/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wheezing Other Serious 2/17/2010 65 Female 3/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 1/30/2010 Female 3/17/2010 Physician United States
Primary
Concomitant
Wheezing Other Serious 65 Female 3/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Wheezing Other Serious 2/17/2010 65 Female 3/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wheezing Other Serious 2/17/2010 65 Female 3/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Influenza Other Serious 5/1/2009 Male 3/29/2010 Canada
Primary
Secondary
Concomitant
Somnolence Hospitalization 1/30/2010 47 Female 4/8/2010 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/14/2009 68 Male 4/20/2010 Physician Japan
Primary
Secondary
Concomitant
Influenza Other Serious 5/1/2009 57 Male 6/9/2010 Canada
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 1/1/2008 63 Female 141 lb 6/22/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Pulmonary Arterial Hypertension Death Male 7/14/2010 Consumer United States
Primary
Concomitant
Pulmonary Arterial Hypertension Death Male 7/29/2010 Other Health Professional United States
Primary
Concomitant
Lymphadenopathy Hospitalization 7/19/2010 42 Female 170 lb 7/26/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Hypokinesia Other Serious Male 8/12/2010 United States
Primary
Concomitant
Mouth Ulceration Disability 11/12/2009 8/17/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Death Hospitalization 23 Female 8/20/2010 Physician United States
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 7/2/2010 42 Male 159 lb 9/1/2010 Pharmacist United States
Primary
Concomitant
Serum Ferritin Increased Other Serious 1/9/2009 79 Female 129 lb 9/27/2010 Pharmacist United States
Primary
Concomitant
Mouth Ulceration Disability 11/12/2009 9/29/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Sickle Cell Anaemia With Crisis Other Serious 4/20/2006 35 Female 176 lb 11/30/2010 United States
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 10/22/2010 67 Female 115 lb 12/3/2010 Physician Canada
Primary
Concomitant
Thrombocytosis Disability 11/12/2009 12/13/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Death 35 Male 153 lb 1/7/2011 Pharmacist United States
Primary
Concomitant
Venoocclusive Liver Disease Death 35 Male 177 lb 1/24/2011 Pharmacist United States
Primary
Secondary
Concomitant
Blood Pressure Decreased Other Serious Female 2/17/2011 Consumer Canada
Primary
Concomitant
Thrombocytopenia Life Threatening 2/18/2011 64 Female 237 lb 2/25/2011 Physician United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 2/9/2011 64 Female 237 lb 3/11/2011 Consumer United States
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 1/1/2009 64 Male 4/15/2011 Physician Italy
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 35 Male 177 lb 4/21/2011 Pharmacist United States
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 9/18/2010 49 Male 176 lb 5/5/2011 Physician Thailand
Primary
Concomitant
Dry Skin 8/29/2010 63 Male 239 lb 5/19/2011 United States
Primary
Concomitant

Drug Data