Alfacalcidol combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ulcerative Keratitis Hospitalization 1/15/2006 Female 108 lb 5/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 1/30/2006 54 Female 8/1/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/14/2005 Female 88 lb 1/19/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 12/19/2006 Female 141 lb 4/5/2007 Belgium
Primary
Concomitant
Arthritis Bacterial Hospitalization 2/16/2007 Female 104 lb 4/17/2007 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 12/19/2006 Female 141 lb 4/18/2007 Belgium
Primary
Concomitant
Abscess Limb Hospitalization 5/9/2007 65 Female 150 lb 5/25/2007 Physician Saudi Arabia
Primary
Concomitant
Abscess Limb Hospitalization 5/9/2007 65 Female 150 lb 8/1/2007 Physician Saudi Arabia
Primary
Concomitant
Joint Swelling Other Serious 12/12/2005 Female 101 lb 9/14/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Colic Other Serious 8/1/2007 58 Female 148 lb 9/17/2007 Greece
Primary
Concomitant
Renal Colic Other Serious 8/1/2007 58 Female 148 lb 9/20/2007 Greece
Primary
Concomitant
Vomiting Hospitalization 4/21/2007 Female 9/28/2007 Other Health Professional Japan
Primary
Concomitant
Renal Colic Other Serious 8/1/2007 Female 148 lb 10/12/2007 Greece
Primary
Concomitant
Renal Colic Other Serious 8/1/2007 Female 148 lb 11/20/2007 Greece
Primary
Concomitant
Herpes Zoster Hospitalization 8/26/2005 Female 71 lb 5/7/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 4/22/2008 Female 75 lb 6/12/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/6/2007 Female 110 lb 7/11/2008 United Kingdom
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 161 lb 8/1/2008 China
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 157 lb 8/14/2008 China
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 157 lb 9/5/2008 China
Primary
Concomitant
Lymphoma Hospitalization 8/27/2007 Female 137 lb 9/19/2008 Physician Japan
Primary
Concomitant
Bronchiectasis Hospitalization 10/1/2008 55 Female 10/14/2008 Consumer Thailand
Primary
Concomitant
Osteomalacia Other Serious 1/1/2006 49 Female 12/1/2008 Physician Jordan
Primary
Concomitant
Thrombocytopenia Hospitalization 12/19/2006 Female 141 lb 12/18/2008 Belgium
Primary
Concomitant
Enterocolitis Bacterial Hospitalization 12/9/2008 Female 79 lb 1/28/2009 Japan
Primary
Concomitant
Paralysis Hospitalization 12/12/2008 Female 140 lb 2/12/2009 Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 Female 86 lb 3/6/2009 Physician Japan
Primary
Concomitant
Bone Pain Other Serious 12/1/2008 Female 4/8/2009 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 2/23/2009 Female 98 lb 4/10/2009 Japan
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 99 lb 4/17/2009 Physician Japan
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 4/3/2009 Male 4/30/2009 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 99 lb 4/30/2009 Physician Japan
Primary
Secondary
Concomitant
Bone Pain Other Serious 12/1/2008 Female 5/4/2009 Japan
Primary
Concomitant
Bone Pain Other Serious 12/1/2008 Female 5/4/2009 Japan
Primary
Concomitant
Pulmonary Mass Hospitalization 7/4/2008 Female 157 lb 5/8/2009 China
Primary
Concomitant
Subcutaneous Emphysema Hospitalization 4/3/2009 Male 5/14/2009 Japan
Primary
Secondary
Concomitant
Bone Pain Other Serious 12/1/2008 Female 5/21/2009 Japan
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 Female 86 lb 5/27/2009 Physician Japan
Primary
Concomitant
Subcutaneous Emphysema Hospitalization 4/3/2009 Male 5/27/2009 Japan
Primary
Secondary
Concomitant
Enterocolitis Bacterial Hospitalization 12/3/2008 Female 79 lb 6/3/2009 Japan
Primary
Concomitant
Bone Pain Other Serious 12/12/2008 Female 6/5/2009 Japan
Primary
Concomitant
Subcutaneous Emphysema Hospitalization 3/21/2009 Male 6/5/2009 Japan
Primary
Secondary
Concomitant
Paralysis Hospitalization 12/12/2008 Female 140 lb 6/9/2009 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 3/9/2009 Female 6/26/2009 Japan
Primary
Concomitant
Vomiting Other Serious 1/1/2007 Female 99 lb 7/6/2009 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 3/9/2009 Female 7/8/2009 Japan
Primary
Concomitant
Pyrexia Hospitalization 9/22/2008 Female 94 lb 7/8/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/18/2009 Male 106 lb 7/13/2009 Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2007 Female 99 lb 7/16/2009 Physician Japan
Primary
Concomitant
Bone Pain Other Serious 12/12/2008 Female 7/16/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/18/2009 Male 106 lb 7/21/2009 Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2007 Female 99 lb 7/27/2009 Physician Japan
Primary
Concomitant
Enterocolitis Bacterial Hospitalization 12/3/2008 Female 79 lb 7/30/2009 Japan
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious 3/24/2009 Female 7/31/2009 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 2/23/2009 Female 98 lb 8/4/2009 Japan
Primary
Concomitant
Enterocolitis Bacterial Hospitalization 12/3/2008 Female 79 lb 8/4/2009 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 2/23/2009 Female 98 lb 8/19/2009 Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 2/23/2009 Female 98 lb 8/20/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/18/2009 Male 106 lb 8/20/2009 Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/30/2009 Female 110 lb 8/21/2009 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/22/2008 Female 94 lb 8/21/2009 Japan
Primary
Concomitant
Visual Acuity Reduced Disability 6/26/2009 Female 90 lb 8/21/2009 Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 7/15/2009 72 Female 114 lb 8/17/2009 Japan
Primary
Concomitant
Visual Impairment Other Serious 6/26/2009 Female 90 lb 8/26/2009 Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 2/23/2009 Female 98 lb 9/2/2009 Japan
Primary
Concomitant
Splenomegaly Other Serious 7/2/2009 Female 9/4/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/18/2009 Male 106 lb 9/9/2009 Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 6/26/2009 Female 90 lb 9/11/2009 Japan
Primary
Secondary
Concomitant
Splenomegaly Life Threatening 7/2/2009 Female 9/21/2009 Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 9/22/2009 Japan
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 7/2/2009 Male 116 lb 9/22/2009 Japan
Primary
Secondary
Concomitant
Supraventricular Tachycardia Other Serious 56 Male 9/25/2009
Primary
Secondary
Paralysis Hospitalization 12/12/2008 Female 140 lb 9/25/2009 Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 7/15/2009 72 Female 114 lb 9/22/2009 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Hospitalization 5/25/2009 Female 82 lb 9/30/2009 Japan
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/14/2009 Female 106 lb 10/5/2009 Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 1/30/2009 Female 110 lb 10/8/2009 Japan
Primary
Secondary
Concomitant
Rib Fracture Other Serious 7/5/2009 Female 10/8/2009 Japan
Primary
Secondary
Concomitant
Putamen Haemorrhage Hospitalization 8/11/2009 62 Male 10/23/2009 Japan
Primary
Concomitant
Hepatitis B Other Serious 10/2/2009 Female 10/28/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Rib Fracture Other Serious 7/5/2009 Female 10/30/2009 Japan
Primary
Secondary
Concomitant
Hepatitis B Dna Increased Other Serious 10/2/2009 Female 11/13/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 9/15/2009 Female 128 lb 11/16/2009 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 11/17/2009 Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 Female 86 lb 11/20/2009 Physician Japan
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 7/2/2009 Male 116 lb 11/23/2009 Japan
Primary
Secondary
Concomitant
Depression Death 11/16/2009 Female 12/2/2009 Japan
Primary
Concomitant
Paralysis Hospitalization 12/12/2008 Female 140 lb 12/4/2009 Japan
Primary
Secondary
Concomitant
Spinal Compression Fracture Hospitalization 5/25/2009 Female 82 lb 12/4/2009 Japan
Primary
Concomitant
Depression Death 11/16/2009 Female 12/14/2009 Japan
Primary
Concomitant
Hepatitis B Dna Increased Other Serious 10/2/2009 Female 362 lb 12/14/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 7/2/2009 Male 116 lb 12/21/2009 Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 9/29/2009 Female 128 lb 1/5/2010 Physician Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 9/29/2009 Female 128 lb 1/13/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/5/2009 Female 1/22/2010 Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 2/3/2010 Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 12/14/2009 Male 132 lb 2/10/2010 Japan
Primary
Concomitant
Renal Failure Acute Hospitalization 8/7/2009 Female 2/19/2010 Japan
Primary
Concomitant
Synovial Rupture Hospitalization 12/16/2009 Female 2/25/2010 Japan
Primary
Secondary
Concomitant
Synovial Rupture Hospitalization 12/16/2009 Female 3/2/2010 Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 7/28/2009 Female 99 lb 3/11/2010 Japan
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 7/25/2009 Female 99 lb 3/12/2010 Japan
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 7/24/2008 Female 86 lb 3/15/2010 Physician Japan
Primary
Secondary
Concomitant
Dizziness Other Serious 6/7/2009 Female 3/17/2010 Japan
Primary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 Male 126 lb 3/25/2010 Japan
Primary
Secondary
Concomitant
Sudden Death Death 1/5/2010 70 Male 123 lb 4/1/2010 Physician Japan
Primary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 61 Male 126 lb 4/5/2010 Japan
Primary
Secondary
Concomitant
Ileus Hospitalization Female 117 lb 4/9/2010 Japan
Primary
Concomitant
Rhabdomyolysis Hospitalization 3/2/2010 73 Female 90 lb 4/14/2010 Japan
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 2/1/2010 61 Male 126 lb 4/15/2010 Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 4/22/2010 Japan
Primary
Secondary
Concomitant
Rectal Ulcer Hospitalization 4/1/2010 82 Female 117 lb 4/29/2010 Physician Japan
Primary
Concomitant
Femur Fracture Hospitalization 7/25/2009 62 Female 99 lb 4/29/2010 Japan
Primary
Concomitant
Sinusitis Hospitalization 3/10/2010 60 Female 154 lb 5/11/2010 Physician Poland
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 7/24/2009 69 Female 99 lb 5/19/2010 Japan
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 3/2/2010 74 Female 5/26/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 8/7/2009 71 Female 89 lb 5/24/2010 Japan
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 12/14/2009 72 Male 132 lb 6/4/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/30/2009 72 Female 95 lb 6/14/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 12/14/2009 72 Male 132 lb 6/14/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/30/2009 72 Female 95 lb 6/15/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/30/2009 72 Female 95 lb 6/18/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 6/28/2010 Physician Japan
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 6/28/2010 Physician Japan
Primary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 6/30/2010 Physician Japan
Primary
Secondary
Concomitant
Cough Hospitalization 12/29/2009 60 Female 122 lb 7/2/2010 Physician Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 12/28/2009 55 Male 6/25/2010 Japan
Primary
Secondary
Concomitant
Seborrhoeic Dermatitis Hospitalization 3/8/2007 59 Female 7/12/2010 Physician Japan
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 7/12/2010 Physician Japan
Primary
Concomitant
Seborrhoeic Dermatitis Hospitalization 3/8/2007 59 Female 7/19/2010 Physician Japan
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 12/28/2009 55 Male 7/14/2010 Japan
Primary
Concomitant
Ventricular Extrasystoles Other Serious 12/28/2009 55 Male 7/19/2010 Japan
Primary
Concomitant
Pancytopenia Hospitalization 7/24/2009 69 Female 99 lb 7/28/2010 Physician Japan
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 7/26/2010 Physician Japan
Primary
Concomitant
Memory Impairment Other Serious Female 101 lb 7/29/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 5/21/2010 43 Female 7/30/2010 Physician Poland
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 8/7/2009 71 Female 89 lb 8/4/2010 Physician Japan
Primary
Concomitant
Cough Hospitalization 12/29/2009 60 Female 122 lb 8/5/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/3/2009 18 Female 8/13/2010 Other Health Professional Japan
Primary
Concomitant
Pruritus Hospitalization 11/24/2006 51 Male 115 lb 8/16/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 8/18/2010 Physician Japan
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 8/18/2010 Physician Japan
Primary
Concomitant
Retrograde Amnesia Disability 7/15/2010 59 Male 8/12/2010 Other Health Professional Japan
Primary
Concomitant
Rash Pruritic Hospitalization 2/26/2010 22 Female 8/19/2010 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Life Threatening 6/26/2010 64 Female 8/20/2010 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 11/24/2006 51 Male 115 lb 8/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Troponin Increased Other Serious 8/6/2010 Female 99 lb 8/25/2010 Other Health Professional Slovenia
Primary
Concomitant
Respiratory Failure Death 72 Male 159 lb 8/27/2010 Physician Greece
Primary
Secondary
Concomitant

Drug Data