Alendronic Acid combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Peripheral Embolism Other Serious 12/15/2004 Female 1/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pelvic Mass Hospitalization 9/1/2005 79 3/7/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tuberculosis Hospitalization 1/1/2006 74 Female 3/10/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/29/2005 73 Female 4/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Soft Tissue Infection Hospitalization 6/19/2006 73 Female 7/31/2006 Consumer United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 8/9/2006 75 Female 9/15/2006 Physician Portugal
Primary
Concomitant
Tachycardia Hospitalization 8/9/2006 75 Female 9/21/2006 Physician Portugal
Primary
Concomitant
Subcorneal Pustular Dermatosis Hospitalization 6/1/2006 Female 11/6/2006 Other Health Professional Norway
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 9/27/2006 Female 1/3/2007 Physician Germany
Primary
Concomitant
Pneumonia Other Serious 7/5/2006 152 lb 1/13/2007 Other Health Professional United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 7/5/2006 152 lb 2/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 5/1/2006 Male 2/21/2007 Physician Netherlands
Primary
Concomitant
Visual Acuity Reduced Other Serious 5/1/2006 Male 3/2/2007 Physician Netherlands
Primary
Concomitant
Muscle Spasms Other Serious 3/15/2007 Female 4/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Cell Carcinoma Stage Unspecified Other Serious 9/1/2006 71 Female 213 lb 6/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Cell Carcinoma Stage Unspecified Life Threatening 9/1/2006 71 Female 213 lb 6/13/2007 United Kingdom
Primary
Secondary
Concomitant
Gastric Cancer Stage Iv Other Serious 6/5/2007 49 Female 6/29/2007 Consumer United Kingdom
Primary
Concomitant
Gastric Cancer Stage Iv Other Serious 6/5/2007 49 Female 7/9/2007 Consumer United Kingdom
Primary
Concomitant
Gastric Cancer Stage Iv Other Serious 6/5/2007 49 Female 7/13/2007 Consumer United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 7/19/2006 Male 130 lb 7/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 7/5/2006 Male 152 lb 7/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Other Serious 9/30/2006 Female 139 lb 8/7/2007 Consumer United Kingdom
Primary
Concomitant
Respiratory Failure Other Serious 6/4/2007 Female 122 lb 8/24/2007 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Other Serious 6/25/2007 Female 123 lb 8/24/2007 United Kingdom
Primary
Concomitant
Sepsis Other Serious 6/25/2007 Female 123 lb 9/14/2007 United Kingdom
Primary
Concomitant
Gastric Cancer Stage Iv Other Serious 6/5/2007 49 Female 10/4/2007 Consumer United Kingdom
Primary
Concomitant
Pyothorax Hospitalization 4/15/2007 Male 212 lb 10/11/2007 United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 12/5/2007 44 Female 179 lb 1/28/2008 Consumer United Kingdom
Primary
Concomitant
Venous Thrombosis Hospitalization 10/1/2007 Female 143 lb 1/28/2008 Consumer Germany
Primary
Concomitant
Venous Thrombosis Hospitalization 8/1/2007 Female 143 lb 2/8/2008 Consumer Germany
Primary
Concomitant
Venous Thrombosis Hospitalization 8/1/2007 Female 143 lb 3/7/2008 Consumer Germany
Primary
Concomitant
Subdural Empyema Life Threatening 61 Female 3/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Streptococcal Infection Life Threatening 61 Female 132 lb 3/21/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Synovial Rupture Hospitalization 10/2/2007 Female 183 lb 4/25/2008 United Kingdom
Primary
Concomitant
Hypokinesia Hospitalization 1/15/2007 Male 126 lb 6/2/2008 United Kingdom
Primary
Concomitant
Breast Cancer Other Serious 67 Female 7/9/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/3/2008 Female 115 lb 7/11/2008 Japan
Primary
Concomitant
Pyelonephritis Acute Hospitalization 7/1/2008 Female 115 lb 7/18/2008 Japan
Primary
Concomitant
Pyelonephritis Acute Hospitalization 7/1/2008 Female 115 lb 7/18/2008 Japan
Primary
Concomitant
Pyelonephritis Acute Hospitalization 7/1/2008 Female 115 lb 7/25/2008 Japan
Primary
Concomitant
Vomiting Other Serious 7/22/2008 58 Female 117 lb 7/30/2008 Pharmacist United Kingdom
Primary
Concomitant
Pyelonephritis Acute Hospitalization 7/1/2008 Female 115 lb 9/24/2008 Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 11/9/2007 Male 167 lb 10/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyelonephritis Acute Hospitalization 7/1/2008 Female 115 lb 10/17/2008 Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 11/9/2007 65 Male 167 lb 11/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lung Cancer Metastatic Other Serious 9/11/2008 Female 119 lb 11/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Lung Cancer Metastatic Other Serious 9/11/2008 Female 119 lb 12/2/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pyelonephritis Acute Hospitalization 7/1/2008 Female 115 lb 12/19/2008 Japan
Primary
Concomitant
Peripheral Vascular Disorder Hospitalization 3/6/2008 Male 123 lb 12/22/2008 United Kingdom
Primary
Concomitant
Uveitis Other Serious 9/1/2008 Female 12/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Temporal Arteritis Other Serious 9/1/2008 Male 143 lb 12/29/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Disorder Life Threatening 9/1/2008 65 Female 180 lb 1/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/14/2008 Female 1/15/2009 Physician United Kingdom
Primary
Concomitant
Spondylolisthesis Hospitalization 11/28/2008 Female 121 lb 1/20/2009 Other Health Professional Portugal
Primary
Secondary
Concomitant
Spondylolisthesis Hospitalization 11/28/2008 Female 121 lb 1/22/2009 Other Health Professional Portugal
Primary
Secondary
Concomitant
Fall Hospitalization 6/1/2008 Female 119 lb 1/22/2009 Other Health Professional United Kingdom
Primary
Concomitant
Joint Prosthesis User Hospitalization 11/3/2007 Female 101 lb 1/22/2009 United Kingdom
Primary
Concomitant
Vasculitis Other Serious 8/20/2008 Female 141 lb 1/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Cyst Hospitalization 11/3/2007 Female 101 lb 1/26/2009 United Kingdom
Primary
Concomitant
Temporal Arteritis Other Serious 9/1/2008 Male 143 lb 2/3/2009 Physician United Kingdom
Primary
Concomitant
Vasculitic Rash Other Serious 12/1/2007 2/6/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 11/5/2008 Female 119 lb 2/10/2009 Other Health Professional United Kingdom
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 9/1/2008 Female 163 lb 3/26/2009 United Kingdom
Primary
Concomitant
Paraesthesia Hospitalization Female 148 lb 4/8/2009 Germany
Primary
Concomitant
Paraesthesia Hospitalization Female 148 lb 4/9/2009 Germany
Primary
Concomitant
Vasospasm Hospitalization 3/18/2008 Female 194 lb 4/14/2009 United Kingdom
Primary
Concomitant
White Blood Cell Disorder Life Threatening 9/1/2008 65 Female 180 lb 4/22/2009 United Kingdom
Primary
Secondary
Concomitant
Sensory Disturbance Other Serious 1/1/2009 47 Female 174 lb 6/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Life Threatening 69 7/22/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pyelonephritis Hospitalization 6/14/2009 Female 7/28/2009 Physician Denmark
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/26/2009 Female 7/31/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 6/17/2009 57 Female 8/3/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pyrexia Hospitalization Male 146 lb 8/4/2009 United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 4/14/2009 Male 146 lb 8/24/2009 United Kingdom
Primary
Concomitant
Muscular Weakness Disability 4/1/2009 Female 9/1/2009 Physician United Kingdom
Primary
Concomitant
Femur Fracture Hospitalization 1/1/2004 61 Male 9/8/2009 Switzerland
Primary
Secondary
Concomitant
Bowen's Disease Other Serious 12/15/2008 Female 9/25/2009 United Kingdom
Primary
Concomitant
Pneumocystis Jiroveci Infection Hospitalization Male 9/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/17/2009 Female 10/13/2009 Physician Denmark
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/26/2009 Female 10/19/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Infection Hospitalization Male 11/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 6/17/2009 Female 11/25/2009 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 3/9/2009 Male 154 lb 11/25/2009 United Kingdom
Primary
Concomitant
Cerebrovascular Accident Life Threatening 4/18/2008 72 Female 12/4/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 8/15/2009 176 lb 12/24/2009 Physician United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 8/15/2009 176 lb 12/30/2009 Physician United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 1/22/2009 69 Female 12/18/2009 United Kingdom
Primary
Concomitant
Intervertebral Disc Degeneration Hospitalization 11/2/2009 69 Female 158 lb 1/19/2010 Physician United States
Primary
Secondary
Concomitant
Intervertebral Disc Degeneration Hospitalization 11/2/2009 69 Female 158 lb 1/29/2010 Physician United States
Primary
Secondary
Concomitant
Tibia Fracture Life Threatening 12/30/2008 65 Male 181 lb 2/3/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 4/15/2009 Female 141 lb 2/3/2010 Consumer Denmark
Primary
Concomitant
Renal Neoplasm Other Serious 10/12/2009 Female 161 lb 2/5/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 4/15/2009 Female 141 lb 2/10/2010 Consumer Denmark
Primary
Concomitant
Muscular Weakness Disability 4/1/2009 Female 115 lb 2/10/2010 Physician United Kingdom
Primary
Concomitant
Renal Mass Other Serious 10/12/2009 Female 161 lb 2/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Fracture Delayed Union Other Serious 76 Female 2/2/2010 Netherlands
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 5/15/2009 Female 205 lb 2/19/2010 United Kingdom
Primary
Concomitant
Death Death 12/11/2009 Female 3/11/2010 Consumer United Kingdom
Primary
Concomitant
Retinal Oedema Other Serious 10/1/2009 Female 137 lb 3/25/2010 Brazil
Primary
Concomitant
Tibia Fracture Life Threatening 12/1/2008 Male 181 lb 3/26/2010 Physician Germany
Primary
Secondary
Concomitant
Tibia Fracture Life Threatening 12/1/2008 Male 181 lb 3/31/2010 Physician Germany
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 4/15/2009 59 Female 141 lb 4/2/2010 Physician Denmark
Primary
Concomitant
Visual Acuity Reduced Other Serious 11/15/2008 62 Female 121 lb 4/16/2010 United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 11/1/2009 59 Female 112 lb 5/3/2010 Physician United Kingdom
Primary
Concomitant
Respiratory Disorder Other Serious Male 5/18/2010 Physician United Kingdom
Primary
Concomitant
Interacting
Throat Lesion Hospitalization Female 187 lb 5/28/2010 Consumer United Kingdom
Primary
Concomitant
Renal Failure Acute Life Threatening 5/16/2010 83 Female 6/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Fistula Other Serious 11/1/2009 56 Female 150 lb 6/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Neoplasm Recurrence Hospitalization 6/1/2010 70 Female 6/25/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Death 6/6/2009 69 Male 7/9/2010 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 2/12/2010 69 Male 7/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 4/15/2009 59 Female 141 lb 7/13/2010 Physician Denmark
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Hospitalization 6/29/2010 59 Male 7/15/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 4/15/2009 59 Female 141 lb 7/20/2010 Physician Denmark
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Hospitalization 6/29/2010 59 Male 7/23/2010 Other Health Professional United Kingdom
Primary
Concomitant
Gait Disturbance Other Serious 6/1/2010 41 Female 126 lb 7/28/2010 Physician Brazil
Primary
Secondary
Concomitant
Gait Disturbance Other Serious 6/1/2010 41 Female 126 lb 8/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Malaise Hospitalization 6/26/2010 58 Female 8/4/2010 Physician France
Primary
Concomitant
Menorrhagia Other Serious 11/25/2008 40 Female 126 lb 8/5/2010 Physician Brazil
Primary
Secondary
Concomitant
Sepsis Death 12/11/2009 77 Female 8/10/2010 Consumer United Kingdom
Primary
Concomitant
Menorrhagia Other Serious 6/1/2010 41 Female 126 lb 8/11/2010 Physician Brazil
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 1/1/2010 68 Female 164 lb 8/23/2010 Consumer Netherlands
Primary
Concomitant
Nausea Hospitalization 8/3/2010 75 Female 10/1/2010 Physician United Kingdom
Primary
Concomitant
Visual Impairment Other Serious 9/1/2010 Female 10/5/2010 Consumer United Kingdom
Primary
Concomitant
Skin Papilloma Hospitalization 2/1/2010 78 Female 179 lb 10/6/2010 Physician Hungary
Primary
Secondary
Concomitant
Nausea Hospitalization 8/3/2010 75 Female 10/7/2010 Physician United Kingdom
Primary
Concomitant
Breast Cancer In Situ Other Serious 6/1/2010 70 Female 10/25/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Hospitalization 10/11/2010 73 Female 130 lb 11/3/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Skin Papilloma Hospitalization 2/1/2010 78 Female 179 lb 11/3/2010 Physician Hungary
Primary
Secondary
Concomitant
Visual Impairment Other Serious 9/1/2010 11/3/2010 Consumer United Kingdom
Primary
Concomitant
Breast Cancer Other Serious 6/14/2010 70 Female 11/4/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Soft Tissue Infection Other Serious 7/25/2010 73 Female 11/4/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/6/2010 Male 159 lb 12/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxoplasmosis Death 7/6/2009 70 Male 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Skin Lesion Other Serious 12/3/2008 72 Female 12/20/2010 Physician United Kingdom
Primary
Concomitant
Soft Tissue Infection Hospitalization 7/25/2010 73 Female 12/22/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Toxoplasmosis Death 7/6/2009 70 Male 12/29/2010 Physician Italy
Primary
Secondary
Concomitant
Off Label Use Other Serious 9/2/2010 65 Female 132 lb 12/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pseudomembranous Colitis Death 7/6/2009 70 Male 1/4/2011 Physician Italy
Primary
Secondary
Concomitant
Laryngeal Ulceration Hospitalization 56 Female 1/12/2011 Consumer Netherlands
Primary
Concomitant
Infection Other Serious 6/17/2009 57 Female 1/10/2011 Physician Denmark
Primary
Secondary
Concomitant
Diverticulum Intestinal Death 3/30/2010 73 Female 137 lb 1/5/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Disability 8/21/2009 29 Female 132 lb 2/8/2011 Consumer United Kingdom
Primary
Concomitant
Vaginal Prolapse Other Serious 9/14/2010 71 Female 194 lb 2/15/2011 Other Health Professional United Kingdom
Primary
Concomitant
Hemiparesis Death 1/1/2007 56 Male 196 lb 2/25/2011 Consumer United Kingdom
Primary
Concomitant
Organising Pneumonia Other Serious 9/1/2010 63 Female 165 lb 3/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 10/11/2010 73 Female 130 lb 3/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Acidosis Death 9/1/2010 63 Female 165 lb 3/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 7/1/2010 63 Female 165 lb 3/17/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 1/22/2011 40 Female 168 lb 3/17/2011 Physician United Kingdom
Primary
Concomitant

Drug Data