Alendronate Sodium combined with Loxonin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Somnolence Life Threatening 5/30/2005 79 Male 4/16/2007
Primary
Secondary
Concomitant
Nausea Hospitalization 6/21/2007 59 Female 7/19/2007 Pharmacist Japan
Primary
Concomitant
Vomiting Other Serious 6/22/2006 80 Male 9/12/2007 Physician Japan
Primary
Concomitant
Vomiting Other Serious 6/22/2006 80 Male 10/12/2007 Physician Japan
Primary
Concomitant
Neuropathy Peripheral Hospitalization 12/24/2007 66 Female 86 lb 2/11/2008 Consumer Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 6/1/2006 Female 101 lb 4/2/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 2/26/2008 Female 4/8/2008 Physician Japan
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 2/26/2008 Female 4/24/2008 Pharmacist Japan
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 2/26/2008 Female 4/30/2008 Physician Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 12/24/2007 66 Female 99 lb 5/5/2008 Consumer Japan
Primary
Concomitant
Hypoglycaemia Hospitalization 3/25/2008 75 Female 5/16/2008 Physician Japan
Primary
Secondary
Concomitant
Optic Neuritis Hospitalization 2/28/2008 39 Female 139 lb 5/16/2008 Physician Japan
Primary
Concomitant
Viral Infection Life Threatening 6/1/2006 Female 101 lb 5/30/2008 Physician Japan
Primary
Concomitant
Hypoglycaemia Hospitalization 3/25/2008 75 Female 6/26/2008 Physician Japan
Primary
Secondary
Concomitant
Glossitis Other Serious 6/16/2008 54 Female 7/2/2008 Physician Japan
Primary
Concomitant
Overdose Other Serious 6/16/2008 54 Female 121 lb 7/11/2008 Pharmacist Japan
Primary
Concomitant
Optic Neuritis Hospitalization 2/28/2008 39 Female 139 lb 7/25/2008 Physician Japan
Primary
Concomitant
Delirium Other Serious 8/31/2008 79 Female 9/12/2008 Physician Japan
Primary
Concomitant
Parkinson's Disease Hospitalization 7/5/2008 Male 9/25/2008 Physician Japan
Primary
Concomitant
Delirium Other Serious 8/31/2008 79 Female 9/29/2008 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/13/2008 Female 141 lb 10/20/2008 Physician Japan
Primary
Concomitant
Stomatitis 6/15/2008 Female 121 lb 10/29/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8/13/2008 Female 134 lb 11/20/2008 Physician Japan
Primary
Concomitant
Vascular Injury Other Serious 11/29/2008 85 Female 88 lb 1/5/2009 Pharmacist Japan
Primary
Concomitant
Vomiting Other Serious 8/13/2008 Female 134 lb 1/15/2009 Physician Japan
Primary
Concomitant
Thirst Other Serious 10/1/2008 2/5/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/13/2008 Female 134 lb 2/19/2009 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Life Threatening 12/31/2008 2/27/2009 Physician Japan
Primary
Secondary
Hepatic Function Abnormal Life Threatening 1/3/2009 3/13/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening 1/3/2009 3/24/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening 1/3/2009 3/30/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8/13/2008 Female 134 lb 4/1/2009 Physician Japan
Primary
Concomitant
Malaise Hospitalization 10/7/2009 59 10/19/2009 Physician Japan
Primary
Concomitant
Malaise Hospitalization 10/7/2009 67 Male 130 lb 11/17/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/7/2009 67 Male 130 lb 11/19/2009 Physician Japan
Primary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/4/2010 Physician Japan
Primary
Concomitant
Septic Shock Hospitalization 12/9/2008 Male 2/12/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 10/7/2009 67 Male 130 lb 3/5/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/14/2009 67 Female 3/22/2010 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Hospitalization 12/9/2008 Male 132 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/14/2009 67 Female 3/29/2010 Physician Japan
Primary
Secondary
Concomitant
Transient Global Amnesia Other Serious 10/14/2009 Female 3/30/2010 Physician Japan
Primary
Concomitant
Pneumonia Cytomegaloviral Life Threatening 2/4/2010 51 Female 119 lb 4/2/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 7/31/2007 69 Female 82 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Glomerulonephritis Acute Other Serious 3/16/2010 61 Female 126 lb 4/6/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 5/15/2009 58 Female 4/15/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 5/15/2009 58 Female 4/23/2010 Physician Japan
Primary
Concomitant
Transient Global Amnesia Other Serious 10/14/2009 63 Female 123 lb 4/26/2010 Physician Japan
Primary
Concomitant
Hyperkalaemia Other Serious 7/28/2010 87 Female 8/11/2010 Physician Japan
Primary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 70 Female 93 lb 12/3/2010 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 1/12/2010 85 Female 1/9/2011 Pharmacist Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2010 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Pleurisy Hospitalization 3/31/2009 1/20/2011 Other Health Professional Japan
Primary
Concomitant
Hyponatraemia Other Serious 1/12/2010 85 Female 1/25/2011 Pharmacist Japan
Primary
Concomitant
Pneumonia Hospitalization 10/1/2010 71 Male 139 lb 1/27/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/22/2011 41 Female 1/28/2011 Physician Japan
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/5/2011 58 Female 2/8/2011 Physician Japan
Primary
Concomitant
Joint Destruction Hospitalization 9/17/2008 70 Female 93 lb 3/29/2011 Physician Japan
Primary
Secondary
Concomitant
Hypertriglyceridaemia Hospitalization 9/17/2008 70 Female 93 lb 4/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/22/2011 41 Female 4/28/2011 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/22/2011 41 Female 5/2/2011 Japan
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 1/5/2011 58 Female 143 lb 5/4/2011 Physician Japan
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/5/2011 58 Female 143 lb 5/9/2011 Physician Japan
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 1/7/2011 58 Female 143 lb 5/13/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Influenzal Death 1/16/2011 54 Female 106 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Disability 2/18/2011 70 Male 7/6/2011 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 4/5/2011 79 Female 7/12/2011 Physician Japan
Primary
Secondary
Aplastic Anaemia Hospitalization 2/18/2011 70 Male 7/13/2011 Physician Japan
Primary
Secondary
Concomitant
Deafness Other Serious 3/1/2011 77 Female 77 lb 7/18/2011 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 1/20/2010 77 Female 93 lb 7/25/2011 Physician Japan
Primary
Secondary
Concomitant
Multi-organ Failure Life Threatening 1/16/2011 54 Female 106 lb 7/27/2011 Consumer Japan
Primary
Secondary
Concomitant
Deafness Other Serious 3/1/2011 77 Female 77 lb 7/27/2011 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 4/5/2011 79 Female 8/1/2011 Physician Japan
Primary
Secondary
Influenza Life Threatening 1/16/2011 54 Female 106 lb 8/2/2011 Consumer Japan
Primary
Secondary
Concomitant
Thyroid Cancer Other Serious 1/25/2011 35 Female 172 lb 8/3/2011 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 4/20/2011 76 Female 118 lb 8/3/2011 Physician Japan
Primary
Concomitant
Haematochezia Other Serious 90 Female 8/9/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 3/5/2010 63 Female 117 lb 8/15/2011 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 7/24/2011 77 Female 66 lb 8/15/2011 Pharmacist Japan
Primary
Concomitant
Pancytopenia Death 4/5/2011 79 Female 8/15/2011 Physician Japan
Primary
Secondary
Pneumonia Hospitalization 7/29/2011 67 Female 8/17/2011 Physician Japan
Primary
Secondary
Concomitant
Dizziness Death 11/26/2010 62 Female 8/30/2011 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 8/31/2011 Physician Japan
Primary
Secondary
Concomitant
Uterine Cancer Hospitalization Female 9/5/2011 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 9/6/2011 Physician Japan
Primary
Secondary
Concomitant
Haematochezia Other Serious 1/1/2011 90 Female 9/7/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 106 lb 9/13/2011 Physician Japan
Primary
Secondary
Concomitant
Condition Aggravated Life Threatening 6/1/2011 75 Male 170 lb 9/12/2011 Consumer Netherlands
Primary
Concomitant
Angina Pectoris Hospitalization 9/2/2011 54 Male 170 lb 9/15/2011 Physician Japan
Primary
Concomitant
Angina Pectoris Hospitalization 9/2/2011 54 Male 170 lb 9/16/2011 Physician Japan
Primary
Concomitant
Altered State Of Consciousness Death 9/1/2011 42 Female 9/16/2011 Physician Japan
Primary
Concomitant
Condition Aggravated Life Threatening 6/1/2011 75 Male 170 lb 9/20/2011 Consumer Netherlands
Primary
Concomitant
Organising Pneumonia Hospitalization 3/1/2010 63 Female 117 lb 9/23/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Death 9/1/2011 42 Female 141 lb 9/28/2011 Physician Japan
Primary
Concomitant
Cardiac Arrest Death 9/9/2011 42 Female 141 lb 9/30/2011 Physician Japan
Primary
Concomitant
Purpura 7/23/2011 77 Female 68 lb 10/6/2011 Pharmacist Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 5/25/2011 76 Female 118 lb 10/6/2011 Other Health Professional Japan
Primary
Concomitant
Shock Hospitalization 9/9/2011 42 Female 141 lb 10/7/2011 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 6/1/2010 43 Female 220 lb 10/10/2011 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 12/2/2010 54 Female 143 lb 10/17/2011 Japan
Primary
Concomitant
Acute Sinusitis Other Serious 6/18/2011 74 Female 93 lb 10/28/2011 Physician Japan
Primary
Concomitant
Rash Other Serious 6/1/2010 43 Female 220 lb 11/2/2011 Other Health Professional Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 5/31/2011 77 Female 110 lb 11/3/2011 Physician Japan
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 5/8/2011 76 Female 118 lb 11/2/2011 Other Health Professional Japan
Primary
Concomitant
Eczema Other Serious 6/1/2010 43 Female 220 lb 11/4/2011 Other Health Professional Japan
Primary
Concomitant
Pancreatitis Acute Death 10/21/2011 57 Female 93 lb 11/7/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 106 lb 11/11/2011 Physician Japan
Primary
Secondary
Concomitant
Viral Infection Hospitalization 12/2/2010 54 Female 143 lb 11/14/2011 Physician Japan
Primary
Concomitant
Gastric Ulcer Hospitalization 4/17/2009 76 Female 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Acute Death 10/21/2011 57 Female 93 lb 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Arthralgia Disability 10/18/2011 69 Female 115 lb 11/23/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 5/31/2011 77 Female 110 lb 11/28/2011 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 10/21/2011 57 Female 12/5/2011 Physician Japan
Primary
Secondary
Concomitant
Brain Oedema Hospitalization 8/7/2011 47 Female 95 lb 12/7/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Sinusitis Death 5/23/2011 74 Female 93 lb 12/8/2011 Physician Japan
Primary
Concomitant
Eyelash Thickening Life Threatening 69 Female 12/9/2011 Consumer Japan
Primary
Secondary
Concomitant
Antibody Test Abnormal Other Serious 7/20/2011 82 Female 123 lb 12/14/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 9/2/2011 76 Female 12/20/2011 Consumer Japan
Primary
Secondary
Concomitant
Arthritis Bacterial Life Threatening 4/17/2009 76 Female 12/20/2011 Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Life Threatening 6/1/2011 75 Male 170 lb 12/23/2011 Physician Netherlands
Primary
Concomitant
Cholecystitis Acute Hospitalization 3/5/2009 64 Male 121 lb 1/2/2012 Japan
Primary
Secondary
Concomitant
Condition Aggravated Life Threatening 6/1/2011 75 Male 170 lb 1/6/2012 Consumer Netherlands
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 12/3/2011 81 Male 122 lb 1/19/2012 Physician Japan
Primary
Secondary
Concomitant
Brain Oedema Hospitalization 8/7/2011 47 Female 95 lb 1/24/2012 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 11/26/2010 62 Female 1/31/2012 Physician Japan
Primary
Concomitant
Condition Aggravated Life Threatening 6/1/2011 75 Male 170 lb 1/30/2012 Physician Netherlands
Primary
Concomitant
Antibody Test Abnormal Other Serious 7/20/2011 82 Female 123 lb 2/2/2012 Physician Japan
Primary
Concomitant
Cytomegalovirus Enterocolitis Hospitalization 7/1/2006 79 Female 119 lb 2/3/2012 Physician Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Life Threatening 6/1/2011 75 Male 170 lb 2/13/2012 Consumer Netherlands
Primary
Concomitant
Conjunctival Hyperaemia Life Threatening 12/28/2011 69 Female 2/22/2012 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Death 11/3/2010 80 Female 101 lb 3/13/2012 Physician Japan
Primary
Concomitant
Wound Infection Other Serious 11/28/2010 78 Female 90 lb 3/19/2012 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 9/2/2011 76 Female 3/22/2012 Consumer Japan
Primary
Secondary
Concomitant
Uterine Cancer Hospitalization Female 3/28/2012 Physician Japan
Primary
Secondary
Concomitant
Uterine Cancer Hospitalization Female 3/28/2012 Physician Japan
Primary
Secondary
Concomitant
Surgery Other Serious 1/1/2010 59 Male 3/29/2012 Japan
Primary
Concomitant
Antibody Test Abnormal Other Serious 7/20/2011 82 Female 123 lb 4/2/2012 Physician Japan
Primary
Concomitant
Antibody Test Abnormal Other Serious 7/20/2011 82 Female 123 lb 4/10/2012 Physician Japan
Primary
Concomitant
Henoch-schonlein Purpura Hospitalization 3/15/2012 72 Male 150 lb 4/10/2012 Physician Japan
Primary
Concomitant
Vomiting Other Serious 11/28/2010 78 Female 90 lb 4/19/2012 Physician Japan
Primary
Concomitant
Surgery Other Serious 1/1/2010 59 Male 4/24/2012 Japan
Primary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 106 lb 5/4/2012 Physician Japan
Primary
Secondary
Concomitant
Deafness Other Serious 1/3/2012 35 Female 5/4/2012 Physician Japan
Primary
Concomitant
Rash Hospitalization 4/11/2012 63 Female 5/16/2012 Japan
Primary
Concomitant
Coronary Artery Stenosis Hospitalization 9/2/2011 54 Male 170 lb 5/17/2012 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/5/2011 66 Female 93 lb 5/25/2012 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 1/6/2009 83 Male 117 lb 5/25/2012 Consumer Japan
Primary
Concomitant
Wound Infection Other Serious 11/28/2010 78 Female 90 lb 5/30/2012 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Other Serious Female 5/31/2012 Physician Japan
Primary
Concomitant

Drug Data