Alendronate combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hepatic Neoplasm Malignant Other Serious 2/16/2007 Female 185 lb 6/1/2009 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Ischaemia Hospitalization 10/28/2008 70 Male 183 lb 6/4/2009 Physician Israel
Primary
Concomitant
Respiratory Distress Life Threatening 8/4/2009 60 Female 11/16/2009 Physician United Kingdom
Primary
Concomitant
Carcinoma In Situ Of Skin Other Serious 1/9/2007 Female 148 lb 11/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Pain Other Serious 3/1/2009 Female 84 lb 12/1/2009 Brazil
Primary
Concomitant
Vomiting Other Serious 6/5/2005 53 Male 174 lb 6/25/2010 Physician United States
Primary
Concomitant
Pneumonia Legionella Other Serious 1/14/2005 63 Male 183 lb 6/28/2010 Physician Germany
Primary
Concomitant
Vomiting Other Serious 6/5/2005 53 Male 174 lb 7/1/2010 Physician United States
Primary
Concomitant
Pneumonia Other Serious 5/20/2010 63 Female 7/6/2010 Physician Czech Republic
Primary
Concomitant
Rhabdomyolysis Other Serious 5/20/2010 63 Female 7/13/2010 Physician Czech Republic
Primary
Concomitant
Visual Impairment Other Serious 1/1/2007 60 Female 139 lb 12/3/2010 Consumer United States
Primary
Concomitant
Visual Impairment Other Serious 1/1/2007 60 Female 139 lb 12/3/2010 Consumer United States
Primary
Concomitant
Foot Fracture Other Serious 11/1/2010 51 Female 104 lb 12/17/2010 Other Health Professional Canada
Primary
Concomitant
Uterine Leiomyoma Hospitalization 5/19/2010 12/15/2010 Other Health Professional Japan
Primary
Concomitant
Arthritis Bacterial Hospitalization 12/27/2010 59 Female 115 lb 1/6/2011 Physician Argentina
Primary
Concomitant
Genital Haemorrhage Hospitalization 1/1/2007 63 Female 140 lb 1/11/2011 Consumer Canada
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 1/1/2011 58 Female 1/27/2011 Other Health Professional Japan
Primary
Concomitant
Headache Other Serious 1/24/2011 45 Male 2/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cellulitis Hospitalization 2/13/2011 61 Female 170 lb 3/8/2011 Physician Peru
Primary
Concomitant
Peritonsillar Abscess Hospitalization 12/24/2010 61 Female 229 lb 3/8/2011 Physician Spain
Primary
Secondary
Concomitant
Hypoaesthesia Life Threatening 1/1/2011 58 Female 2/25/2011 Other Health Professional Japan
Primary
Concomitant
Malaise Other Serious 2/26/2011 78 Female 102 lb 3/21/2011 Consumer Canada
Primary
Concomitant
Cellulitis Hospitalization 2/6/2011 61 Female 170 lb 3/31/2011 Physician Peru
Primary
Concomitant
Thrombosis Hospitalization 7/2010 Female 196 lb 2/15/2013 Physician Country Not Specified
Primary
Secondary
Concomitant
Syringe Issue Other Serious 3/15/2011 52 Female 206 lb 11/11/2013 Consumer Us
Primary
Concomitant
Suprapubic Pain Hospitalization 12/12/2010 74 Female 3/12/2013 Physician Country Not Specified
Primary
Concomitant
Myelocytosis Other Serious 4/5/2011 45 Female 9/24/2012 Physician Fr
Primary
Concomitant
Urinary Bladder Haemorrhage Hospitalization 8/2011 Female 140 lb 12/13/2012 Physician Ca
Primary
Concomitant
Urinary Tract Infection Other Serious 8/2011 65 Female 140 lb 12/24/2013 Physician Ca
Primary
Concomitant
Diabetes Mellitus Other Serious 1/1/2012 Female 10/15/2012 Physician De
Primary
Concomitant
Diabetes Mellitus Other Serious 1/1/2012 Female 7/30/2013 Physician De
Primary
Concomitant
Sepsis Other Serious Female 198 lb 9/18/2012 Physician Gb
Primary
Concomitant
Off Label Use Death 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Subdural Haematoma Death 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Death 11/6/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Death 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Venoocclusive Disease Death 9/13/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Stem Cell Transplant Death 9/14/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Death 9/13/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Off Label Use Other Serious 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Pancreatitis Other Serious 9/12/2012 Other Health Professional Ca
Primary
Secondary
Concomitant
Incorrect Route Of Drug Administration 8/28/2012 60 Female 220 lb 9/5/2012 Consumer Us
Primary
Concomitant
Syncope Hospitalization 8/13/2008 62 Female 194 lb 11/22/2013 Physician Br
Primary
Secondary
Concomitant
Product Quality Issue Other Serious 6/2012 Female 9/14/2012 Consumer Country Not Specified
Primary
Concomitant
Erythema Other Serious 7/2012 55 Female 111 lb 8/1/2013 Physician Country Not Specified
Primary
Concomitant
Systemic Lupus Erythematosus Rash Hospitalization 1/2012 59 Female 10/10/2012 Physician Us
Primary
Secondary
Concomitant
Blood Test Abnormal Other Serious 9/2012 64 Male 163 lb 10/16/2013 Other Health Professional Ca
Primary
Concomitant
Herpes Zoster 9/2012 Female 10/15/2012 Consumer Ca
Primary
Concomitant
Metastatic Neoplasm Hospitalization 10/1/2012 82 Male 2/7/2013 Physician Gb
Primary
Concomitant
Dizziness 62 Female 10/25/2012 Physician Us
Primary
Concomitant
Injection Site Swelling Female 10/25/2012 Physician Us
Primary
Concomitant
Nasopharyngitis Male 195 lb 10/24/2012 Other Health Professional Us
Primary
Concomitant
Nasopharyngitis 11/2011 49 Male 128 lb 10/25/2012 Other Health Professional Us
Primary
Concomitant
Injection Site Swelling 3/15/2012 64 Female 10/25/2012 Other Health Professional Us
Primary
Concomitant
Menstruation Irregular 46 Female 10/25/2012 Physician Us
Primary
Concomitant
Upper-airway Cough Syndrome 7/21/2012 71 Female 110 lb 10/26/2012 Physician Us
Primary
Concomitant
Vomiting Life Threatening 4/28/2012 71 Female 4/22/2013 Consumer Us
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Hospitalization 12/13/2011 76 Male 176 lb 2/8/2013 Physician Gb
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/24/2012 66 Male 12/3/2012 Physician Ca
Primary
Concomitant
Weight Decreased Other Serious 83 Male 11/2/2012 Other Health Professional Nz
Primary
Concomitant
Agranulocytosis Hospitalization 10/16/2012 71 Male 146 lb 12/17/2012 Physician Jp
Primary
Concomitant
Septic Shock Death 7/2012 66 Male 187 lb 11/22/2012 Other Health Professional De
Primary
Concomitant
Fatigue Female 11/8/2012 Other Health Professional Us
Primary
Concomitant
Oral Herpes 2/10/2012 53 Female 120 lb 11/13/2012 Physician Us
Primary
Concomitant
Neurological Decompensation Other Serious 51 Female 165 lb 11/16/2012 Physician Ae
Primary
Concomitant
Visual Acuity Reduced Other Serious 2009 53 Female 11/20/2012 Consumer Co
Primary
Concomitant
Vomiting Life Threatening 4/28/2012 71 Female 11/28/2012 Consumer Us
Primary
Secondary
Concomitant
Spinal Cord Neoplasm Hospitalization 8/2012 52 Female 174 lb 3/14/2013 Physician Ca
Primary
Concomitant
Neutrophilia Hospitalization 83 Male 12/17/2012 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Thyroid Mass Other Serious 11/1/2012 57 Female 132 lb 12/28/2012 Consumer Co
Primary
Concomitant
Wheelchair User Other Serious 6/2012 Female 3/1/2013 Physician Us
Primary
Concomitant
Myalgia Hospitalization 12/25/2012 74 Female 1/11/2013 Consumer Co
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 12/19/2012 39 Female 163 lb 2/4/2013 Physician Jp
Primary
Secondary
Concomitant
Pneumonia Aspiration Other Serious 2012 71 Female 170 lb 1/24/2013 Physician Country Not Specified
Primary
Concomitant
Vaginal Infection 1/26/2012 57 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Sinusitis 1/14/2012 67 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 7/2011 58 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Post Procedural Complication 2010 74 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Psoriasis 11/2011 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Death Death NotSpecified 1/30/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Influenza Death NotSpecified 10/15/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Femoral Neck Fracture Hospitalization 5/23/2012 Male 2/7/2013 Physician Gb
Primary
Concomitant
Weight Loss Poor Hospitalization 6/26/2010 Female 181 lb 3/20/2013 Consumer Br
Primary
Concomitant
Venoocclusive Disease Death NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Influenza Death NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization Female 128 lb 2/13/2013 Consumer Br
Primary
Concomitant
Drug Ineffective Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Tenderness 2012 Male 152 lb 1/31/2013 Consumer Us
Primary
Concomitant
Asthenia Other Serious NotSpecified 2/15/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease 2011 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Drug Dose Omission 4/20/2012 53 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Pelvic Pain Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Ileus Other Serious NotSpecified 2/13/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Pain Of Skin 11/10/2012 39 Female 148 lb 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Tendonitis Other Serious 10/21/2012 59 Female 157 lb 7/29/2013 Physician Country Not Specified
Primary
Concomitant
Tooth Extraction 9/14/2012 58 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Laceration 11/2012 53 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Subdural Haematoma Other Serious NotSpecified 2/11/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Multi-organ Failure Death NotSpecified 2/11/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Myopathy Other Serious NotSpecified 2/12/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Meningitis Pneumococcal Death NotSpecified 2/13/2013 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Ileus Other Serious NotSpecified 2/13/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious NotSpecified 2/14/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Pneumonia Fungal Other Serious 9/5/2012 71 Male 101 lb 4/15/2013 Physician Jp
Primary
Secondary
Concomitant
Drug Dose Omission 7/30/2012 Male 172 lb 2/19/2013 Consumer Us
Primary
Concomitant
Vomiting Hospitalization 2/21/2013 NotSpecified 221 lb 4/4/2013 Physician Country Not Specified
Primary
Concomitant
Basal Cell Carcinoma Other Serious 64 Female 104 lb 4/4/2013 Consumer Us
Primary
Concomitant
Foot Fracture Other Serious 1/29/2013 60 Female 205 lb 3/13/2013 Consumer Ca
Primary
Concomitant
Weight Increased Hospitalization 12/19/2012 Female 3/15/2013 Consumer Br
Primary
Concomitant
Sudden Death Death 2/12/2013 86 Female 5/15/2013 Consumer Jp
Primary
Secondary
Concomitant
Convulsion Other Serious 12/2012 38 Female 112 lb 4/4/2013 Physician Country Not Specified
Primary
Concomitant
Death Death Female 188 lb 4/1/2013 Other Health Professional Ca
Primary
Concomitant
Mental Disorder Other Serious 2012 78 Female 115 lb 4/12/2013 Consumer Br
Primary
Concomitant
Neoplasm Other Serious 9/11/2012 66 Female 8/14/2013 Physician Jp
Primary
Concomitant
Metastases To Liver Death 12/2010 55 Female 170 lb 9/17/2013 Physician Us
Primary
Concomitant
Pancytopenia Other Serious 77 Male 4/30/2013 Other Health Professional Gb
Primary
Concomitant
Interacting
Pneumonia Aspiration Hospitalization 4/8/2013 62 Female 5/21/2013 Physician Jp
Primary
Concomitant
Pyrexia Hospitalization 3/1/2013 53 Male 128 lb 5/3/2013 Consumer Co
Primary
Concomitant
Pancytopenia Other Serious 77 Male 5/7/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Neuroendocrine Carcinoma Of The Skin Other Serious 10/2011 55 Female 250 lb 7/16/2013 Consumer Us
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 4/2013 82 Male 7/12/2013 Physician Country Not Specified
Primary
Concomitant
Femoral Neck Fracture Hospitalization 5/19/2013 81 Female 138 lb 8/13/2013 Other Health Professional Ca
Primary
Concomitant
Rectal Haemorrhage Other Serious 5/31/2013 35 Female 250 lb 6/11/2013 Other Health Professional Ca
Primary
Concomitant
Uterine Leiomyoma Hospitalization 6/4/2013 53 Female 206 lb 8/6/2013 Physician Us
Primary
Concomitant
Depression Hospitalization 5/8/2013 59 Female 155 lb 6/24/2013 Other Health Professional Ca
Primary
Concomitant
Death Death 6/20/2013 83 Male 6/26/2013 Physician Us
Primary
Concomitant
Herpes Zoster Other Serious 6/3/2013 78 Male 156 lb 7/8/2013 Physician Us
Primary
Concomitant
Osteomyelitis Hospitalization 9/2011 52 Female 136 lb 7/3/2013 Physician Country Not Specified
Primary
Concomitant
Meningitis Other Serious 6/8/2013 53 Male 108 lb 7/5/2013 Consumer Country Not Specified
Primary
Concomitant
Tardive Dyskinesia Disability 2005 Female Us
Primary
Concomitant
Cough Other Serious 9/2010 63 Female 7/25/2013 Lawyer Dk
Primary
Concomitant
Syncope Hospitalization 6/27/2013 63 Male 192 lb 7/19/2013 Other Health Professional Ca
Primary
Concomitant
Road Traffic Accident Death Female 165 lb 7/19/2013 Consumer Country Not Specified
Primary
Concomitant
Polychondritis Hospitalization 2007 48 Female 161 lb 7/26/2013 Consumer Br
Primary
Concomitant
Vomiting Life Threatening 4/12/2013 40 Female 88 lb 8/22/2013 Physician Jp
Primary
Concomitant
Influenza Death NotSpecified 10/16/2013 Other Health Professional De
Primary
Secondary
Concomitant
Osteoarthritis Hospitalization 2012 Male 158 lb 8/15/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Oedema Peripheral Other Serious 10/2012 72 Female 140 lb 8/26/2013 Consumer Ca
Primary
Secondary
Concomitant
Breast Cancer Hospitalization 8/13/2013 59 Female 10/17/2013 Other Health Professional Ca
Primary
Concomitant
White Blood Cell Count Decreased Female 194 lb 9/26/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Intracranial Pressure Increased Other Serious 3/2013 54 Female 9/4/2013 Consumer Ca
Primary
Concomitant
Speech Disorder Other Serious 9/3/2013 75 Female 9/23/2013 Consumer Us
Primary
Concomitant
Stomatitis Other Serious 52 Male 9/14/2013 Other Health Professional It
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/14/2012 74 Female 108 lb 10/26/2013 Physician Ca
Primary
Concomitant
Prostate Cancer Other Serious 73 Male 170 lb 9/18/2013 Physician Us
Primary
Concomitant
Thrombosis Death Female 165 lb 9/27/2013 Consumer Country Not Specified
Primary
Concomitant
Large Intestine Polyp 7/12/2012 65 Female 105 lb 9/30/2013 Physician Us
Primary
Concomitant
Urinary Tract Infection Other Serious 75 Female 132 lb 9/30/2013 Physician Us
Primary
Concomitant
Rhinorrhoea 1/2/2013 56 Female 10/1/2013 Physician Us
Primary
Concomitant
Weight Increased Other Serious 7/23/2012 77 Female 135 lb 6/10/2013 Physician Ca
Primary
Secondary
Concomitant

Drug Data