Aflibercept combined with Irinotecan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Malnutrition Hospitalization 8/23/2012 59 Male 183 lb 9/28/2012 Physician Nl
Primary
Secondary
Concomitant
Colonic Fistula Hospitalization 10/12/2012 59 Male 11/21/2012 Physician At
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 9/4/2012 66 Male 11/21/2012 Other Health Professional At
Primary
Secondary
General Physical Health Deterioration Hospitalization 57 Male 11/21/2012 Other Health Professional At
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 11/14/2012 69 Male 2/4/2013 It
Primary
Secondary
Diarrhoea Required Intervention 11/15/2012 66 Male 12/3/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Productive Cough Hospitalization 11/19/2012 59 Male 1/8/2013 Gb
Primary
Secondary
Concomitant
Skin Reaction Disability 10/26/2012 Male 11/4/2013 Physician My
Primary
Secondary
Sepsis Hospitalization 11/25/2012 66 Female 12/7/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/25/2012 66 Female 12/20/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/26/2012 65 Male 1/21/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/27/2012 74 Male 6/14/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Skin Reaction Disability 11/11/2012 NotSpecified 1/2/2013 Physician My
Primary
Secondary
Skin Ulcer Disability 11/11/2012 Male 11/8/2013 Physician My
Primary
Secondary
Sepsis Life Threatening 12/2/2012 73 Male 1/21/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Hypotension Life Threatening 1/8/2013 56 Male 9/6/2013 Physician Fi
Primary
Secondary
Concomitant
Ileus Paralytic Other Serious 1/2/2013 72 Male 10/11/2013 Physician It
Primary
Secondary
Concomitant
Diverticulitis Hospitalization 11/24/2012 62 Female 12/10/2012 Physician Nl
Primary
Secondary
Concomitant
Hepatitis B Hospitalization 1/7/2013 51 Female 128 lb 5/3/2013 Physician Cn
Primary
Secondary
Concomitant
Syncope Life Threatening 1/8/2013 56 Male 1/21/2013 Other Health Professional Fi
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 12/14/2012 64 Male 8/2/2013 Physician Gb
Primary
Secondary
Concomitant
Hypercalcaemia Hospitalization 1/3/2013 56 Female 3/12/2013 Physician Il
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/19/2012 68 Male 1/12/2013 Physician Gb
Primary
Secondary
Concomitant
Pulmonary Embolism Death 1/2/2013 61 Male 2/13/2013 Other Health Professional Il
Primary
Secondary
Concomitant
Disease Progression Death 9/20/2012 78 Male 8/7/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/12/2012 55 Female 12/2/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Disease Progression Death Male 3/19/2013 Physician Gb
Primary
Secondary
Systemic Inflammatory Response Syndrome Death 2/2013 73 Male 3/21/2013 Other Health Professional De
Primary
Secondary
Concomitant
Hypertension Other Serious 12/14/2012 64 Female 5/21/2013 Dk
Primary
Secondary
Concomitant
Pneumonia Hospitalization 12/7/2012 72 NotSpecified 2/12/2013 Physician Gb
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/20/2012 78 Male 11/15/2013 Es
Primary
Secondary
Concomitant
Faeces Discoloured Hospitalization 72 Male 2/12/2013 Physician Gb
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 1/14/2013 64 Male 2/12/2013 Other Health Professional Es
Primary
Secondary
Hypertensive Crisis Hospitalization 1/14/2013 56 Female 2/18/2013 Physician My
Primary
Secondary
Concomitant
Toothache Hospitalization 12/11/2012 64 Male 7/12/2013 Other Health Professional Fi
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/26/2012 65 NotSpecified 2/13/2013 Physician Gb
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/30/2013 69 Male 3/8/2013 Other Health Professional Se
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/30/2013 69 Male 10/11/2013 Other Health Professional Se
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/20/2013 53 Female 9/24/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 2/3/2013 63 Male 3/28/2013 Physician Za
Primary
Secondary
Vomiting Hospitalization 12/1/2012 54 Male 3/8/2013 Other Health Professional It
Primary
Secondary
Blood Alkaline Phosphatase Increased Other Serious 2/8/2013 64 Female 3/29/2013 Physician Fr
Primary
Secondary
Concomitant
Hypertension Other Serious NotSpecified 3/14/2013 Other Health Professional Be
Primary
Secondary
General Physical Health Deterioration Hospitalization 3/3/2013 62 Female 5/8/2013 Physician De
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 11/14/2012 69 Male 3/22/2013 Other Health Professional It
Primary
Secondary
Respiratory Failure Hospitalization 11/22/2012 67 Male 3/21/2013 Physician Es
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 11/15/2012 66 Male 3/21/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Hospitalization 12/3/2013 66 Male 12/2/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Troponin I Increased Hospitalization 3/10/2013 75 Male 8/30/2013 Gb
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 2/8/2013 64 Female 4/3/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Bone Marrow Failure Hospitalization 3/22/2013 76 Female 10/9/2013 Physician Fr
Primary
Secondary
Concomitant
Faeces Discoloured Hospitalization 3/4/2013 63 Male 4/2/2013 Physician Za
Primary
Secondary
Vomiting Hospitalization 1/3/2013 56 Female 3/15/2013 Other Health Professional Il
Primary
Secondary
Concomitant
Intestinal Perforation Hospitalization 3/7/2013 55 Female 4/12/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/12/2013 71 Female 6/7/2013 Other Health Professional It
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 3/20/2013 65 Male 10/2/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/24/2013 73 Male 9/13/2013 Other Health Professional De
Primary
Secondary
Concomitant
Hypotension Life Threatening 1/8/2013 56 Male 9/10/2013 Other Health Professional Fi
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 12/14/2012 64 Male 8/8/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Disease Progression Hospitalization 1/29/2013 82 Male 9/19/2013 Physician Fr
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 3/22/2013 76 Female Other Health Professional Fr
Primary
Secondary
Respiratory Failure Hospitalization 3/31/2013 69 Male 10/11/2013 It
Primary
Secondary
Tracheal Obstruction Life Threatening 3/31/2013 69 Male 10/4/2013 Other Health Professional It
Primary
Secondary
Concomitant
Neutropenia Life Threatening 4/15/2013 60 Male 11/15/2013 Other Health Professional Es
Primary
Secondary
Concomitant
Hypertension Disability 4/16/2013 71 Female 5/13/2013 Physician Gb
Primary
Secondary
Concomitant
Neutropenia Hospitalization 3/6/2013 65 Male 5/8/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 4/24/2013 45 Female 6/27/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 4/17/2013 56 Male 4/9/2013 De
Primary
Secondary
Concomitant
Hepatitis B Hospitalization 1/14/2013 51 NotSpecified 5/9/2013 Cn
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Life Threatening 5/5/2013 70 Female 7/19/2013 Other Health Professional Il
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/19/2012 68 Male 4/16/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Somnolence Hospitalization 2/7/2013 54 Female 6/3/2013 Other Health Professional Br
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 5/3/2013 78 Male 10/18/2013 Physician De
Primary
Secondary
Concomitant
Intestinal Perforation Hospitalization 5/7/2013 49 Female 5/22/2013 Other Health Professional Be
Primary
Secondary
Concomitant
Mitral Valve Incompetence Hospitalization 5/9/2013 45 Male 6/18/2013 Other Health Professional It
Primary
Secondary
Concomitant
Hypertension Hospitalization 5/13/2013 62 Female 11/14/2013 Other Health Professional Nl
Primary
Secondary
Concomitant
Vesical Fistula Hospitalization 5/13/2013 46 Male 7/11/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 5/7/2013 74 Male 8/16/2013 Other Health Professional It
Primary
Secondary
Concomitant
Nausea Hospitalization 4/11/2013 71 Male 10/11/2013 Other Health Professional Es
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 5/20/2013 63 Male 6/6/2013 Other Health Professional Es
Primary
Secondary
Peripheral Ischaemia Hospitalization 6/5/2013 76 Male 8/23/2013 Physician De
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Death 6/4/2013 61 Male 12/17/2013 Physician Nl
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/1/2013 72 Female 6/26/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 6/11/2013 50 Female 108 lb 11/15/2013 Physician Cn
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/21/2013 53 Female 10/2/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Death 6/4/2013 61 Male 6/27/2013 Other Health Professional Nl
Primary
Secondary
Diarrhoea Hospitalization 5/27/2013 55 Male 6/14/2013 Other Health Professional Gb
Primary
Secondary
Diarrhoea Hospitalization 5/2013 46 Male 6/19/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 6/3/2013 71 Male 7/17/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/1/2013 78 Female 10/30/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 6/7/2013 68 Male 8/29/2013 Other Health Professional Es
Primary
Secondary
Sepsis Hospitalization 5/21/2013 34 Female 8/14/2013 Other Health Professional Gb
Primary
Secondary
Upper Gastrointestinal Haemorrhage Life Threatening Male 7/8/2013 Other Health Professional Gb
Primary
Secondary
Vena Cava Thrombosis Other Serious 6/4/2013 NotSpecified 7/3/2013 Other Health Professional Cy
Primary
Secondary
Pyrexia Hospitalization 6/18/2013 65 Female 12/6/2013 Other Health Professional Be
Primary
Secondary
Concomitant
Cough Hospitalization 6/13/2013 49 Male 12/9/2013 Other Health Professional De
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization Male 7/17/2013 Other Health Professional Gb
Primary
Secondary
Chest Pain Hospitalization 6/26/2013 76 Female 11/5/2013 Other Health Professional De
Primary
Secondary
Concomitant
Thrombosis In Device Hospitalization 7/1/2013 63 Male 8/5/2013 Other Health Professional Es
Primary
Secondary
Concomitant
Fatigue Hospitalization 6/28/2013 48 Female 110 lb 12/10/2013 Physician Cn
Primary
Secondary
Concomitant
Skin Discolouration Hospitalization 6/5/2013 76 Male 8/29/2013 Other Health Professional De
Primary
Secondary
Concomitant
Neutropenia Hospitalization 7/7/2013 76 Male 8/7/2013 Other Health Professional De
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 7/20/2013 43 Female 163 lb 7/31/2013 Physician Be
Primary
Secondary
Febrile Neutropenia Hospitalization 7/9/2013 44 Male 8/28/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Fatigue Hospitalization 7/6/2013 65 Male 7/26/2013 Other Health Professional It
Primary
Secondary
Concomitant
Respiratory Failure Death 7/9/2013 48 Female 12/18/2013 Other Health Professional Cn
Primary
Secondary
Concomitant
Neutropenia Hospitalization 7/17/2013 76 Male 9/4/2013 Physician De
Primary
Secondary
Concomitant
Pelvic Fluid Collection Hospitalization 7/24/2013 61 Male 12/11/2013 Physician Gb
Primary
Secondary
Concomitant
Xerosis Other Serious NotSpecified 8/12/2013 Other Health Professional Ru
Primary
Concomitant
Thrombosis In Device Hospitalization 7/7/2013 66 Male 9/18/2013 Other Health Professional Be
Primary
Secondary
Concomitant
Pelvic Venous Thrombosis Hospitalization 7/24/2013 76 Female 10/15/2013 Other Health Professional De
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 6/25/2013 66 Female 8/9/2013 Physician It
Primary
Secondary
Concomitant
Pulmonary Mass Life Threatening 7/24/2013 61 Male 11/26/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/18/2013 65 Female 8/23/2013 Physician Be
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 5/12/2013 66 NotSpecified 8/23/2013 Other Health Professional Es
Primary
Secondary
Hip Fracture Death 7/11/2013 68 Male 10/8/2013 Physician Es
Primary
Secondary
Concomitant
Wound Infection Hospitalization 6/1/2013 64 Male 10/24/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Hip Fracture Death 7/11/2013 68 Male Other Health Professional Es
Primary
Secondary
Concomitant
Intestinal Perforation Death 4/26/2013 66 Male 11/19/2013 Other Health Professional Es
Primary
Secondary
Concomitant
Thrombosis In Device Death 5/10/2013 47 Male 11/19/2013 Physician Es
Primary
Secondary
Concomitant
Renal Failure Acute Death 8/26/2013 60 Male 9/23/2013 Physician Gb
Primary
Concomitant
Pyrexia Hospitalization 8/14/2013 49 Male 12/20/2013 Other Health Professional De
Primary
Secondary
Concomitant
Sepsis Hospitalization 8/25/2013 57 Male 9/24/2013 Th
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 8/27/2013 50 Male 9/19/2013 Other Health Professional Br
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 9/2/2013 52 Male 11/22/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Melaena Life Threatening 8/20/2013 57 Male 11/21/2013 Other Health Professional It
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 66 Male 9/27/2013 Physician Us
Primary
Concomitant
Diarrhoea Hospitalization 2/20/2013 46 Male 10/1/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/26/2012 65 Male 10/11/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 4/24/2013 46 Male 10/2/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/19/2013 58 Female 11/1/2013 Es
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 8/12/2013 78 Female 10/9/2013 Us
Primary
Secondary
Concomitant
Phlebitis Hospitalization 9/6/2013 55 Female 10/30/2013 Fr
Primary
Secondary
Scrotal Ulcer Other Serious 54 Male 10/24/2013 Other Health Professional My
Primary
Concomitant
Sepsis Death 10/9/2013 63 Male 12/11/2013 Other Health Professional It
Primary
Secondary
Concomitant
Gallbladder Perforation Hospitalization 10/14/2013 68 Male 114 lb 11/8/2013 Physician Sg
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/13/2013 68 Male 11/27/2013 Sg
Primary
Secondary
Concomitant
Enteritis Hospitalization 10/16/2013 79 Male 11/21/2013 Other Health Professional Es
Primary
Secondary
Mucosal Inflammation Disability 10/6/2013 77 Female 12/19/2013 Other Health Professional De
Primary
Secondary
Infection Hospitalization 10/25/2013 73 Male 11/20/2013 Physician Fr
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Hospitalization 10/28/2013 68 Female 12/9/2013 Other Health Professional Jp
Primary
Secondary
Concomitant
Nephrotic Syndrome Hospitalization 10/31/2013 51 Female 12/12/2013 Other Health Professional Il
Primary
Secondary
Concomitant
Hypertension Hospitalization 10/28/2013 75 Male 12/3/2013 De
Primary
Secondary
Concomitant
Neutropenia Hospitalization 11/6/2013 65 Male 12/3/2013 Other Health Professional De
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/21/2013 44 Female 11/27/2013 Other Health Professional Lb
Primary
Secondary
Concomitant
Decreased Appetite Hospitalization 62 Male 11/25/2013 Jp
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 11/12/2013 73 Female 12/20/2013 Other Health Professional De
Primary
Secondary
Concomitant
Lower Gastrointestinal Haemorrhage Other Serious 10/30/2013 41 Male 11/28/2013 Other Health Professional Hk
Primary
Secondary
Febrile Neutropenia Hospitalization 11/1/2013 62 Male 12/5/2013 Other Health Professional Ca
Primary
Secondary
Concomitant
Hypophagia Hospitalization 11/8/2013 62 Male 12/6/2013 Jp
Primary
Secondary
Concomitant

Drug Data