Afinitor combined with Oxycontin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Decreased Disability 5/10/2009 Male 6/29/2009 Physician United States
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization Male 178 lb 11/11/2009 Physician United States
Primary
Concomitant
Thrombosis Death 8/23/2009 Male 152 lb 11/20/2009 United States
Primary
Secondary
Concomitant
Metastases To Liver Other Serious 7/1/2008 Male 179 lb 12/7/2009 Physician France
Primary
Secondary
Concomitant
Anaemia Hospitalization 6/22/2009 Female 129 lb 12/30/2009 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/8/2010 55 Male 241 lb 4/19/2010 Physician United States
Primary
Secondary
Concomitant
Death Death 4/30/2010 48 Male 5/10/2010 Physician Japan
Primary
Concomitant
Mouth Ulceration Other Serious 3/22/2010 72 Male 5/13/2010 Physician Australia
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 4/7/2010 63 Male 5/17/2010 United States
Primary
Concomitant
Pneumonia Other Serious 4/1/2010 48 Male 5/18/2010 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 4/14/2010 62 Male 97 lb 6/1/2010 Physician Japan
Primary
Secondary
Mouth Ulceration Other Serious 3/22/2010 72 Male 6/14/2010 Physician Australia
Primary
Concomitant
Stomatitis Hospitalization 4/14/2010 62 Male 97 lb 6/11/2010 Physician Japan
Primary
Secondary
Stomatitis Hospitalization 4/14/2010 62 Male 97 lb 6/14/2010 Physician Japan
Primary
Secondary
Stomatitis Hospitalization 4/14/2010 62 Male 97 lb 6/25/2010 Physician Japan
Primary
Secondary
Transient Ischaemic Attack Hospitalization 4/7/2010 63 Male 178 lb 6/25/2010 United States
Primary
Concomitant
Vomiting Hospitalization 5/25/2010 63 Female 7/12/2010 Physician United States
Primary
Secondary
Concomitant
Malaise Other Serious 6/15/2010 77 Male 139 lb 7/13/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 7/14/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 7/16/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 7/11/2010 59 Male 7/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Mouth Ulceration Other Serious 3/22/2010 72 Male 7/22/2010 Physician Australia
Primary
Concomitant
Stomatitis Hospitalization 4/14/2010 62 Male 97 lb 7/26/2010 Physician Japan
Primary
Secondary
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 7/28/2010 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 6/29/2010 68 Female 115 lb 8/2/2010 Physician Japan
Primary
Concomitant
Skin Exfoliation Other Serious 5/6/2010 57 Male 179 lb 8/9/2010 Physician Japan
Primary
Concomitant
Mouth Ulceration Other Serious 3/22/2010 72 Male 8/11/2010 Physician Australia
Primary
Concomitant
Pyrexia Other Serious 6/15/2010 77 Male 139 lb 8/13/2010 Physician Japan
Primary
Concomitant
Respiratory Disorder Hospitalization 6/29/2010 68 Female 115 lb 8/13/2010 Physician Japan
Primary
Secondary
Concomitant
Thoracic Cavity Drainage Hospitalization 7/31/2010 64 Male 8/20/2010 Physician Switzerland
Primary
Concomitant
Vomiting Hospitalization 4/14/2010 63 Female 8/20/2010 Physician United States
Primary
Secondary
Concomitant
Road Traffic Accident Hospitalization 8/3/2010 69 Female 101 lb 8/31/2010 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Other Serious 4/14/2010 48 Male 9/7/2010 Physician Japan
Primary
Concomitant
Pneumonia Aspiration Hospitalization Male 110 lb 9/7/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 7/1/2010 45 Male 132 lb 9/8/2010 Physician Japan
Primary
Concomitant
Hyperglycaemia Other Serious 7/13/2010 62 Male 9/13/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Disorder Other Serious 4/14/2010 48 Male 9/13/2010 Physician Japan
Primary
Concomitant
Wheezing Other Serious 6/15/2010 77 Male 139 lb 9/14/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 2/26/2010 64 Female 9/20/2010 Physician Australia
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/11/2010 59 Male 9/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Anal Fistula Hospitalization 5/18/2010 63 Male 10/4/2010 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Other Serious 6/8/2010 48 Male 10/4/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 7/11/2010 59 Male 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Disorder Hospitalization 6/29/2010 68 Female 115 lb 10/11/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 9/16/2010 45 Male 10/14/2010 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 6/20/2010 62 Male 10/15/2010 Physician Japan
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Hospitalization Male 110 lb 10/20/2010 Physician Japan
Primary
Concomitant
Osteomyelitis Other Serious 6/2/2010 45 Male 10/20/2010 Physician Japan
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 7/29/2010 52 Male 10/21/2010 Physician Japan
Primary
Concomitant
Acute Hepatic Failure Death 9/24/2010 64 Male 187 lb 10/25/2010 Physician Australia
Primary
Concomitant
Platelet Count Decreased Other Serious 6/20/2010 62 Male 10/27/2010 Physician Japan
Primary
Secondary
Concomitant
Oral Pain Death 62 Female 179 lb 11/3/2010 Consumer United States
Primary
Concomitant
Wheezing Other Serious 6/15/2010 77 Male 139 lb 11/5/2010 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 3/20/2010 60 Male 11/15/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 7/1/2010 45 Male 132 lb 11/17/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 8/24/2010 55 Male 11/19/2010 Physician Japan
Primary
Concomitant
Respiratory Disorder Hospitalization 6/29/2010 68 Female 115 lb 11/19/2010 Physician Japan
Primary
Concomitant
Stomatitis Other Serious Male 11/29/2010 United States
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 8/30/2010 44 Male 12/2/2010 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 62 Male 11/16/2010 Denmark
Primary
Secondary
Concomitant
Death Death 9/8/2010 62 Male 12/9/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 8/31/2010 55 Male 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Malaise Other Serious 7/17/2010 67 Male 12/14/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Death Male 110 lb 12/16/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Death 9/8/2010 62 Male 12/17/2010 Physician Japan
Primary
Concomitant
Respiratory Distress Other Serious 8/24/2010 55 Male 12/17/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 7/17/2010 67 Male 12/21/2010 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 10/16/2010 67 Male 141 lb 12/23/2010 Physician Japan
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 5/6/2010 70 Female 12/27/2010 Physician Japan
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 3/22/2010 72 Male 12/27/2010 Physician Australia
Primary
Concomitant
Small Intestinal Haemorrhage Hospitalization 11/21/2010 54 Male 163 lb 12/28/2010 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 1/11/2010 62 Male 12/28/2010 Physician Denmark
Primary
Concomitant
Interacting
Platelet Count Increased Other Serious 7/5/2010 63 Female 126 lb 12/29/2010 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/20/2010 62 Male 12/29/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 5/6/2010 57 Male 179 lb 12/29/2010 Physician Japan
Primary
Concomitant
Right Ventricle Outflow Tract Obstruction Other Serious 4/14/2010 48 Male 12/30/2010 Physician Japan
Primary
Concomitant
Cancer Pain Death 4/14/2010 48 Male 1/6/2011 Physician Japan
Primary
Concomitant
Abdominal Abscess Hospitalization 9/14/2010 80 Male 1/7/2011 Physician Japan
Primary
Concomitant
Polyneuropathy Other Serious 10/1/2010 59 Female 1/13/2011 Physician Switzerland
Primary
Secondary
Concomitant
Pneumonia Bacterial Death 6/8/2010 48 Male 1/21/2011 Physician Japan
Primary
Concomitant
Cancer Pain Hospitalization 4/14/2010 48 Male 1/24/2011 Physician Japan
Primary
Concomitant
Oedema Peripheral Hospitalization 8/1/2010 70 Female 1/24/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 8/31/2010 55 Male 1/25/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 10/25/2010 61 Male 143 lb 1/28/2011 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 8/24/2010 55 Male 1/28/2011 Physician Japan
Primary
Concomitant
Vein Disorder Disability 11/1/2010 59 Male 2/8/2011 Other Health Professional United States
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 1/24/2011 66 Female 2/11/2011 Physician Japan
Primary
Concomitant
Hypokalaemia Other Serious 7/5/2010 63 Female 126 lb 2/15/2011 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/20/2010 62 Male 2/15/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 1/28/2011 51 Male 2/23/2011 Other Health Professional Italy
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 8/24/2010 55 Male 119 lb 3/1/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Other Serious 8/31/2010 55 Male 3/9/2011 Physician Japan
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Hospitalization 3/2/2011 50 Male 245 lb 3/10/2011 Physician United States
Primary
Concomitant
Swelling Hospitalization 3/2/2011 50 Male 245 lb 3/14/2011 Physician United States
Primary
Concomitant
Pneumonia Bacterial Death 8/19/2010 70 Male 3/15/2011 Physician Japan
Primary
Concomitant
Accident Death Male 3/16/2011 Physician Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 11/21/2010 54 Male 163 lb 3/28/2011 Physician Japan
Primary
Concomitant
Diverticulum Intestinal Haemorrhagic Other Serious 6/20/2010 62 Male 4/1/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 5/6/2010 57 Male 179 lb 4/5/2011 Physician Japan
Primary
Concomitant
Skin Toxicity Other Serious 1/28/2011 51 Male 4/7/2011 Physician Italy
Primary
Concomitant
Renal Cell Carcinoma Stage Iv Hospitalization 8/31/2010 55 Male 4/8/2011 Physician Japan
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 4/14/2010 62 Male 97 lb 4/13/2011 Physician Japan
Primary
Secondary
General Physical Health Deterioration Other Serious 6/8/2010 48 Male 4/15/2011 Physician Japan
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 1/21/2011 67 Male 4/19/2011 Physician Japan
Primary
Concomitant
Lymphocyte Count Decreased Other Serious 7/5/2010 63 Female 126 lb 4/20/2011 Physician Japan
Primary
Concomitant
Road Traffic Accident Hospitalization 8/4/2010 69 Female 101 lb 4/27/2011 Physician Japan
Primary
Concomitant
Nausea Other Serious 6/20/2010 62 Male 5/18/2011 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/8/2010 55 Male 241 lb 5/20/2011 Physician United States
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 9/14/2010 80 Male 5/23/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Death 8/19/2010 70 Male 5/23/2011 Physician Japan
Primary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 4/27/2011 63 Male 5/24/2011 Physician Japan
Primary
Concomitant
Blood Pressure Decreased Hospitalization 11/5/2010 56 Male 5/24/2011 Physician Japan
Primary
Concomitant
Pneumothorax Hospitalization 5/18/2011 62 Male 176 lb 5/24/2011 Physician United States
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 7/5/2010 63 Female 126 lb 5/26/2011 Physician Japan
Primary
Concomitant
Tumour Associated Fever Other Serious 5/6/2010 70 Female 6/1/2011 Physician Japan
Primary
Secondary
Concomitant
Haematemesis Other Serious 5/3/2010 57 Male 179 lb 6/2/2011 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 10/16/2010 67 Male 141 lb 6/6/2011 Physician Japan
Primary
Concomitant
Rash Generalised Death 5/3/2010 57 Male 179 lb 6/6/2011 Physician Japan
Primary
Concomitant
Mental Status Changes Hospitalization 6/4/2011 62 Male 169 lb 6/13/2011 Physician United States
Primary
Concomitant
Haemoglobin Decreased Other Serious 3/25/2010 60 Male 6/14/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 10/19/2010 44 Male 183 lb 6/14/2011 Physician Japan
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 4/23/2011 62 Male 139 lb 6/15/2011 Physician Japan
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 1/21/2011 67 Male 6/22/2011 Physician Japan
Primary
Concomitant
Enteritis Hospitalization 4/8/2010 55 Male 241 lb 6/28/2011 Physician United States
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 6/4/2011 62 Male 169 lb 7/1/2011 Physician United States
Primary
Concomitant
Pneumonia Bacterial Other Serious 8/19/2010 70 Male 7/4/2011 Physician Japan
Primary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 4/27/2011 63 Male 7/5/2011 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Other Serious Female 7/13/2011 United States
Primary
Concomitant
Neoplasm Malignant Death 8/31/2010 61 Male 115 lb 7/11/2011 Physician Japan
Primary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious 4/23/2011 62 Male 139 lb 7/21/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 1/24/2011 66 Female 8/2/2011 Physician Japan
Primary
Concomitant
Renal Failure Acute Other Serious 10/18/2010 44 Male 183 lb 8/2/2011 Physician Japan
Primary
Concomitant
Dyspnoea Other Serious 8/19/2010 70 Male 8/12/2011 Physician Japan
Primary
Concomitant
C-reactive Protein Increased Other Serious 11/21/2010 52 Female 115 lb 8/16/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Hospitalization 4/14/2011 58 Female 8/23/2011 Physician Japan
Primary
Concomitant
Mental Disorder Hospitalization 1/21/2011 67 Male 141 lb 8/24/2011 Physician Japan
Primary
Concomitant
Lipid Metabolism Disorder Disability 7/9/2009 42 Female 8/30/2011 Lawyer United States
Primary
Concomitant
Platelet Count Decreased Other Serious 8/13/2010 65 Female 8/30/2011 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 7/9/2009 42 Female 8/31/2011 Lawyer United States
Primary
Concomitant
Anaemia Other Serious 1/24/2011 66 Female 9/7/2011 Physician Japan
Primary
Concomitant
Neoplasm Progression Death 6/20/2011 71 Female 9/14/2011 Physician Japan
Primary
Concomitant
Rash Generalised Other Serious 5/3/2010 57 Male 179 lb 9/16/2011 Physician Japan
Primary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 4/15/2011 63 Male 9/20/2011 Physician Japan
Primary
Concomitant
Rectal Haemorrhage Hospitalization 9/11/2011 72 Male 9/21/2011 Physician Australia
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Disability 7/9/2009 42 Female 9/27/2011 Physician United States
Primary
Concomitant
Impaired Gastric Emptying Disability 7/9/2009 42 Female 10/3/2011 Physician United States
Primary
Concomitant
Neoplasm Malignant Other Serious 8/2/2010 60 Male 143 lb 10/3/2011 Physician Japan
Primary
Concomitant
Nasal Congestion Other Serious 7/9/2009 42 Female 10/7/2011 Lawyer United States
Primary
Concomitant
Large Intestinal Haemorrhage Hospitalization 9/11/2011 72 Male 10/11/2011 Physician Australia
Primary
Secondary
Concomitant
Rhinorrhoea Hospitalization 7/9/2009 42 Female 10/20/2011 Physician United States
Primary
Concomitant

Drug Data