Afinitor combined with Levothyroxine Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Exfoliation Other Serious 6/1/2009 Male 191 lb 6/30/2009 Other Health Professional United States
Primary
Concomitant
Vaginal Discharge Other Serious 11/2/2009 Female 12/3/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 12/9/2009 31 Male 150 lb 12/18/2009 Physician United States
Primary
Concomitant
Thrombosis In Device Other Serious 6/30/2009 Female 12/23/2009 Physician France
Primary
Concomitant
Anaemia Hospitalization 6/22/2009 Female 129 lb 12/30/2009 Physician United States
Primary
Concomitant
Metastases To Bone Other Serious 11/1/2009 Female 1/6/2010 Consumer Germany
Primary
Concomitant
Mucosal Inflammation Other Serious 12/9/2009 31 Male 150 lb 1/6/2010 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 11/30/2009 Female 103 lb 1/21/2010 Physician Korea, Republic Of
Primary
Concomitant
Waist Circumference Increased Hospitalization 1/24/2010 69 Male 205 lb 2/12/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/22/2004 Male 187 lb 2/22/2010 Physician Germany
Primary
Concomitant
Mucosal Inflammation Other Serious 12/9/2009 31 Male 150 lb 2/24/2010 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 11/30/2009 Female 103 lb 3/4/2010 Physician Korea, Republic Of
Primary
Concomitant
Weight Decreased Other Serious 2/4/2010 Female 3/25/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/22/2004 68 Male 187 lb 4/2/2010 Physician Germany
Primary
Concomitant
Oedema Hospitalization 4/12/2010 63 Female 35 lb 4/26/2010 Physician Italy
Primary
Concomitant
Paracentesis Disability 4/12/2010 63 Female 110 lb 4/30/2010 Physician Italy
Primary
Concomitant
Sepsis Other Serious 2/5/2010 68 Male 5/17/2010 United States
Primary
Concomitant
Unresponsive To Stimuli Death 12/10/2009 72 Male 164 lb 5/18/2010 Physician United States
Primary
Concomitant
Weight Increased Other Serious Female 5/20/2010 Physician France
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 12/10/2009 72 Male 164 lb 5/20/2010 Physician United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 2/18/2010 81 Male 143 lb 6/1/2010 Physician Italy
Primary
Concomitant
Vaginal Discharge Other Serious 11/2/2009 63 Female 6/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Vaginal Discharge Other Serious 11/2/2009 63 Female 6/16/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Interacting
Tremor Other Serious 9/7/2009 72 Female 6/24/2010 Other Health Professional Germany
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 12/30/2008 62 Female 141 lb 6/25/2010 Physician France
Primary
Concomitant
Oedema Other Serious 11/1/2009 72 Female 6/28/2010 Other Health Professional Germany
Primary
Concomitant
Pruritus Generalised Life Threatening 5/31/2010 65 Female 227 lb 7/5/2010 Physician Mexico
Primary
Concomitant
Hemiplegia Life Threatening 10/12/2009 42 Male 176 lb 7/7/2010 Physician Lebanon
Primary
Concomitant
Hemiplegia Life Threatening 10/12/2009 42 Male 176 lb 7/8/2010 Physician Lebanon
Primary
Concomitant
Vaginal Discharge Other Serious 11/2/2009 63 Female 7/30/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Interacting
Renal Failure Hospitalization 7/15/2010 62 Male 8/3/2010 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 8/10/2010 58 Female 138 lb 8/20/2010 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/15/2010 62 Male 9/21/2010 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 12/16/2009 62 Female 9/21/2010 Physician United Kingdom
Primary
Concomitant
Interacting
Vena Cava Thrombosis Hospitalization 9/21/2010 36 Female 183 lb 10/18/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 8/26/2010 72 Male 165 lb 11/3/2010 Physician Germany
Primary
Concomitant
Thrombosis Other Serious 11/4/2010 76 Male 12/7/2010 Other Health Professional Germany
Primary
Concomitant
Pulmonary Embolism Hospitalization 9/21/2010 36 Female 183 lb 1/11/2011 Physician United States
Primary
Secondary
Concomitant
Inflammation Death 5/1/2010 72 Male 165 lb 1/19/2011 Physician Germany
Primary
Concomitant
Blood Glucose Increased Other Serious 12/23/2010 82 Female 1/24/2011 Consumer Germany
Primary
Concomitant
Lymphoedema Other Serious 11/4/2010 76 Male 1/31/2011 Physician Germany
Primary
Concomitant
Dizziness Other Serious 12/27/2010 82 Female 133 lb 2/2/2011 Consumer Germany
Primary
Concomitant
Abdominal Distension Other Serious 6/19/2010 72 Male 118 lb 2/4/2011 Physician Hong Kong
Primary
Concomitant
Lymphoedema Other Serious 11/4/2010 76 Male 1/31/2011 Physician Germany
Primary
Concomitant
Death Death Male 2/28/2011 Physician United States
Primary
Concomitant
Dyspnoea Hospitalization 1/25/2011 59 Male 3/31/2011 Physician Germany
Primary
Concomitant
Dehydration Life Threatening 5/31/2010 65 Female 227 lb 5/4/2011 Physician Mexico
Primary
Concomitant
Vomiting Other Serious 3/27/2011 62 Male 185 lb 5/9/2011 Physician United States
Primary
Secondary
Concomitant
Oedema Hospitalization 4/19/2011 56 Male 203 lb 5/9/2011 Physician France
Primary
Concomitant
Drug Administration Error Other Serious 11/1/2010 74 Female 5/26/2011 Consumer Germany
Primary
Concomitant
Transaminases Increased Other Serious 1/16/2011 53 Female 126 lb 6/1/2011 Physician France
Primary
Concomitant
Neoplasm Malignant Hospitalization 8/9/2010 63 Female 5/31/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 10/26/2010 52 Male 134 lb 6/22/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 10/18/2010 53 Male 141 lb 6/23/2011 Physician Japan
Primary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious Male 6/28/2011 Physician Japan
Primary
Concomitant
Blood Creatine Increased Death 10/4/2010 68 Female 146 lb 7/20/2011 Physician Austria
Primary
Secondary
White Blood Cell Count Decreased Other Serious 3/8/2011 74 Female 7/27/2011 Consumer United States
Primary
Concomitant
Blood Creatinine Increased Death Female 8/3/2011 Physician Austria
Primary
Secondary
Concomitant
Epilepsy Hospitalization 7/1/2011 59 Female 8/11/2011 Physician Japan
Primary
Concomitant
Syncope Other Serious 8/4/2011 61 Male 237 lb 8/12/2011 Physician United States
Primary
Concomitant
Fatigue Other Serious Male 8/16/2011 United States
Primary
Concomitant
Neoplasm Progression Other Serious 3/23/2011 59 Male 134 lb 8/16/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Hospitalization 4/14/2011 58 Female 8/23/2011 Physician Japan
Primary
Concomitant
General Physical Health Deterioration Hospitalization 8/12/2011 59 Male 203 lb 8/24/2011 Physician Germany
Primary
Concomitant
Platelet Count Decreased Other Serious 8/13/2010 65 Female 8/30/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Thyroid Stimulating Hormone Increased Other Serious 9/27/2010 71 Male 126 lb 8/30/2011 Physician Japan
Primary
Concomitant
Renal Function Test Abnormal Other Serious 1/7/2011 74 Female 8/31/2011 Consumer Germany
Primary
Concomitant
Angina Pectoris Hospitalization 8/21/2011 75 Female 9/8/2011 Physician Australia
Primary
Concomitant
Neoplasm Progression Other Serious 9/28/2010 52 Male 134 lb 9/12/2011 Physician Japan
Primary
Concomitant
Blood Glucose Increased Hospitalization 8/18/2011 59 Male 203 lb 9/16/2011 Physician Germany
Primary
Concomitant
Intestinal Obstruction Hospitalization 6/19/2010 72 Male 118 lb 9/26/2011 Physician Hong Kong
Primary
Concomitant
Hypercreatininaemia Hospitalization Male 10/4/2011 Other Health Professional France
Primary
Concomitant
Neoplasm Progression Death 2/28/2011 Female 10/5/2011 Physician Austria
Primary
Secondary
Concomitant
Malaise Other Serious 8/17/2011 21 Female 210 lb 10/7/2011 Consumer United States
Primary
Concomitant
Death Death 11/9/2010 59 Male 10/7/2011 Physician Japan
Primary
Concomitant
Pancytopenia Other Serious 4/19/2011 61 Male 10/10/2011 Physician Japan
Primary
Concomitant
Malaise Hospitalization 1/13/2011 72 Male 128 lb 10/11/2011 Other Health Professional Japan
Primary
Concomitant
Decreased Appetite Death 2/1/2011 62 Male 10/13/2011 Physician United Kingdom
Primary
Secondary
Concomitant
C-reactive Protein Increased Other Serious 6/24/2010 71 Male 126 lb 10/14/2011 Physician Japan
Primary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 3/31/2011 76 Female 128 lb 10/19/2011 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/14/2011 79 Male 148 lb 10/20/2011 Physician Germany
Primary
Concomitant
Neoplasm Progression Other Serious 4/14/2011 58 Female 10/20/2011 Physician Japan
Primary
Concomitant
Wheezing Other Serious 1/13/2011 72 Male 128 lb 10/21/2011 Other Health Professional Japan
Primary
Concomitant
Alanine Aminotransferase Increased Other Serious 8/12/2011 75 Female 128 lb 10/28/2011 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/1/2011 62 Male 10/28/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Neoplasm Progression Other Serious 5/2/2011 75 Female 137 lb 11/2/2011 Physician Japan
Primary
Concomitant
Diarrhoea Other Serious 3/8/2011 72 Male 117 lb 11/9/2011 Physician Japan
Primary
Concomitant
Renal Failure Other Serious 4/14/2011 58 Female 11/15/2011 Physician Japan
Primary
Concomitant
Malignant Neoplasm Of Pleura Other Serious 8/1/2011 66 Male 163 lb 11/21/2011 Physician Germany
Primary
Secondary
Concomitant
Circulatory Collapse Other Serious 11/12/2011 59 Male 159 lb 11/24/2011 Physician Germany
Primary
Concomitant
Neoplasm Progression Hospitalization 5/14/2010 71 Male 137 lb 11/29/2011 Physician Japan
Primary
Concomitant
Pulmonary Toxicity Hospitalization 6/7/2011 72 Male 12/1/2011 Other Health Professional Italy
Primary
Concomitant
Cholestasis Other Serious 11/21/2011 63 Female 119 lb 12/1/2011 Physician Germany
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 9/28/2010 52 Male 134 lb 12/2/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 3/23/2011 59 Male 134 lb 12/2/2011 Physician Japan
Primary
Concomitant
Heat Illness Hospitalization Male 150 lb 12/2/2011 Physician Japan
Primary
Concomitant
Wheezing Hospitalization 1/13/2011 72 Male 128 lb 12/13/2011 Other Health Professional Japan
Primary
Concomitant
Photophobia 85 Female 10/7/2011 Other Health Professional United States
Primary
Concomitant
Convulsion Other Serious 8/14/2011 21 Female 10/7/2011 Consumer United States
Primary
Concomitant
Oral Pain 6/15/2011 21 Female 10/7/2011 Consumer United States
Primary
Concomitant
Death Death 11/3/2011 66 Male 12/14/2011 United States
Primary
Concomitant
Lung Neoplasm Death 11/3/2011 66 Male 12/20/2011 United States
Primary
Concomitant
Neoplasm Malignant Other Serious 8/9/2010 63 Female 12/21/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Toxicity Hospitalization 6/7/2011 72 Male 12/26/2011 Other Health Professional Italy
Primary
Concomitant
Oedema Peripheral Other Serious 6/30/2010 66 Female 1/4/2012 Physician United States
Primary
Secondary
Concomitant
Circulatory Collapse Other Serious 11/12/2011 59 Male 159 lb 1/17/2012 Physician Germany
Primary
Concomitant
Vertigo Positional Hospitalization 12/27/2011 24 Female 207 lb 1/17/2012 Physician Germany
Primary
Secondary
Concomitant
Vertigo Positional Hospitalization 12/27/2011 24 Female 207 lb 1/24/2012 Physician Germany
Primary
Secondary
Concomitant
Hypertension Hospitalization 12/1/2011 Male 2/6/2012 Physician Czech Republic
Primary
Concomitant
Cough Other Serious 8/3/2011 59 Female 2/7/2012 Physician United States
Primary
Secondary
Concomitant
Vertigo Positional Hospitalization 12/27/2011 24 Female 207 lb 2/9/2012 Physician Germany
Primary
Secondary
Concomitant
Gastrointestinal Oedema Hospitalization 1/26/2012 44 Male 2/10/2012 Physician Italy
Primary
Concomitant
Malaise Disability 1/13/2011 72 Male 128 lb 2/15/2012 Other Health Professional Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 3/31/2011 76 Female 128 lb 2/20/2012 Physician Japan
Primary
Concomitant
Vertigo Positional Hospitalization 12/27/2011 24 Female 207 lb 2/23/2012 Physician Germany
Primary
Secondary
Concomitant
Abdominal Pain Upper 2/17/2012 68 Female 2/18/2012 Pharmacist United States
Primary
Concomitant
Abdominal Pain Upper 2/17/2012 68 Female 2/18/2012 Pharmacist United States
Primary
Concomitant
Pyrexia Hospitalization 1/26/2012 44 Male 2/24/2012 Consumer Italy
Primary
Concomitant
Pyrexia Other Serious 3/8/2011 72 Male 117 lb 2/29/2012 Physician Japan
Primary
Concomitant
Dysgeusia 6/18/2011 85 Female 1/4/2012 Consumer United States
Primary
Concomitant
Malaise 1/27/2011 29 Male 1/4/2012 Consumer United States
Primary
Concomitant
Sleep Disorder Other Serious 6/30/2010 66 Female 3/5/2012 Consumer United States
Primary
Secondary
Concomitant
Anaemia Life Threatening 11/1/2011 80 Male 134 lb 3/13/2012 Physician Japan
Primary
Concomitant
Acute Myocardial Infarction Hospitalization 1/1/2011 61 Male 174 lb 3/15/2012 Physician Germany
Primary
Concomitant
Hypercalcaemia Hospitalization 2/27/2012 64 Female 202 lb 3/19/2012 Physician Israel
Primary
Secondary
Concomitant
Thirst Other Serious Male 7/5/2011 Consumer United States
Primary
Concomitant
Fatigue 3/23/2011 73 Female 125 lb 7/5/2011 Consumer United States
Primary
Concomitant
Dizziness 3/23/2011 73 Female 125 lb 7/5/2011 Consumer United States
Primary
Concomitant
Weight Decreased 79 Female 10/5/2010 Consumer United States
Primary
Concomitant
Blood Glucose Increased Other Serious Male 7/5/2011 Consumer United States
Primary
Concomitant
C-reactive Protein Increased Other Serious 3/23/2011 59 Male 134 lb 3/27/2012 Physician Japan
Primary
Concomitant
Heat Illness Hospitalization Male 150 lb 4/3/2012 Physician Japan
Primary
Concomitant
Liver Disorder Other Serious 5/17/2010 58 Male 123 lb 4/4/2012 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 6/30/2010 66 Female 4/4/2012 Consumer United States
Primary
Secondary
Concomitant
Inflammation Other Serious 6/30/2010 66 Female 4/4/2012 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/27/2012 70 Female 179 lb 4/5/2012 Physician France
Primary
Secondary
Concomitant
Anaemia Death 11/1/2011 80 Male 134 lb 4/17/2012 Physician Japan
Primary
Concomitant
Atrial Fibrillation Hospitalization 2/27/2012 64 Female 202 lb 4/18/2012 Physician Israel
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 4/9/2012 63 Female 155 lb 4/27/2012 Physician United States
Primary
Concomitant
Confusional State Hospitalization 2/27/2012 64 Female 202 lb 4/30/2012 Other Health Professional Israel
Primary
Secondary
Concomitant
Dyspnoea Other Serious 3/9/2012 80 Female 5/2/2012 Consumer United States
Primary
Concomitant
Blood Glucose Increased Other Serious 11/12/2011 59 Male 159 lb 5/2/2012 Physician Germany
Primary
Concomitant
Chronic Lymphocytic Leukaemia Other Serious 10/1/2011 87 Female 125 lb 12/22/2011 Physician United States
Primary
Concomitant
C-reactive Protein Increased Hospitalization 11/1/2011 80 Male 134 lb 5/22/2012 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 8/13/2010 65 Female 5/25/2012 Physician Japan
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Hospitalization 12/1/2011 76 Female 134 lb 5/25/2012 Physician Germany
Primary
Concomitant
Hypertriglyceridaemia Life Threatening Male 5/29/2012 Physician France
Primary
Concomitant
Diarrhoea Other Serious 3/8/2011 72 Male 117 lb 6/15/2012 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 10/3/2011 77 Male 101 lb 6/15/2012 Physician Japan
Primary
Concomitant
Neoplasm Malignant Death 7/17/2010 67 Male 6/15/2012 Physician Japan
Primary
Concomitant

Drug Data