Afinitor combined with Exemestane

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Hospitalization 9/3/2010 69 Female 10/7/2010 Norway
Primary
Secondary
Oesophageal Stenosis Hospitalization 4/27/2011 64 Female 185 lb 6/14/2011 Physician United States
Primary
Secondary
Oesophageal Stenosis Hospitalization 4/27/2011 64 Female 185 lb 6/17/2011 Physician United States
Primary
Secondary
Intestinal Perforation Other Serious 4/27/2011 64 Female 185 lb 6/27/2011 Physician United States
Primary
Secondary
Intestinal Perforation Hospitalization 4/27/2011 64 Female 185 lb 6/30/2011 Physician United States
Primary
Secondary
Retinal Artery Thrombosis Other Serious 7/22/2011 67 Female 117 lb 8/16/2011 Physician France
Primary
Secondary
Retinal Artery Thrombosis Other Serious 7/22/2011 67 Female 117 lb 10/24/2011 Physician France
Primary
Secondary
Pyrexia Female 12/8/2011 Consumer United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Other Serious 7/22/2011 67 Female 117 lb 12/21/2011 Physician France
Primary
Secondary
Vomiting Life Threatening Female 2/8/2012 United States
Primary
Secondary
Concomitant
Dyspnoea Life Threatening Female 2/8/2012 United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 3/6/2012 61 Female 121 lb 3/19/2012 Physician Japan
Primary
Secondary
Concomitant
Dyspepsia Hospitalization 12/14/2010 71 Female 127 lb 3/21/2012 Other Health Professional Poland
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 3/6/2012 61 Female 121 lb 3/28/2012 Physician Japan
Primary
Secondary
Concomitant
Blood Oestrogen Increased 5/8/2012 Physician United States
Primary
Interacting
Febrile Neutropenia Hospitalization 12/14/2010 71 Female 127 lb 5/29/2012 Other Health Professional Poland
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 5/1/2012 64 Female 6/6/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious Female 7/6/2012 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/12/2011 68 Female 159 lb 7/10/2012 Other Health Professional France
Primary
Secondary
Escherichia Infection Other Serious 4/12/2011 68 Female 159 lb 7/11/2012 Other Health Professional France
Primary
Secondary
Escherichia Infection Hospitalization 4/12/2011 68 Female 159 lb 7/12/2012 Physician France
Primary
Secondary
Abdominal Abscess Other Serious 4/12/2011 68 Female 159 lb 7/17/2012 Other Health Professional France
Primary
Secondary
Hyponatraemia Other Serious Female 8/27/2012 Physician Canada
Primary
Concomitant
Renal Failure Death 7/2012 Female 150 lb 8/30/2012 Consumer Country Not Specified
Primary
Concomitant
Toothache Hospitalization Female 9/7/2012 Physician Us
Primary
Concomitant
Nausea Death 7/2012 Female 118 lb 10/11/2012 Physician Us
Primary
Concomitant
Dyspnoea Hospitalization 7/12/2012 79 Female 148 lb 10/3/2012 Physician Us
Primary
Concomitant
Dyspnoea Death 9/6/2012 66 Female 104 lb 10/4/2012 Physician Us
Primary
Concomitant
Pulmonary Embolism Hospitalization 8/16/2012 72 Male 187 lb 10/4/2012 Physician De
Primary
Concomitant
Nausea Death Female 110 lb 2/26/2013 Consumer Us
Primary
Concomitant
Vomiting Death 3/2012 Female 10/8/2012 Other Health Professional Us
Primary
Concomitant
Respiratory Failure Death Female 124 lb 10/23/2012 Physician Us
Primary
Concomitant
Weight Decreased Hospitalization 9/25/2012 55 Female 135 lb 10/12/2012 Physician Us
Primary
Concomitant
Vision Blurred Hospitalization Female 10/22/2012 Physician Us
Primary
Concomitant
Thrombocytopenia Death 8/9/2012 57 Female 10/26/2012 Physician De
Primary
Concomitant
Sepsis Hospitalization 8/14/2012 53 Female 130 lb 11/2/2012 Other Health Professional Us
Primary
Concomitant
Pneumonitis Hospitalization 10/10/2012 69 Female 143 lb 11/9/2012 Physician De
Primary
Concomitant
Death Death Female 11/21/2012 Consumer Country Not Specified
Primary
Concomitant
Skin Ulcer Other Serious 10/24/2012 Female 165 lb 1/30/2013 Other Health Professional De
Primary
Concomitant
Respiratory Failure Hospitalization Female 146 lb 1/11/2013 Physician Us
Primary
Secondary
Hypomagnesaemia Hospitalization 12/12/2012 12/24/2012 Physician Nl
Primary
Secondary
Nausea Disability 10/15/2012 54 Female 128 lb 12/26/2012 Pharmacist Gb
Primary
Concomitant
Hypoacusis Other Serious 12/20/2012 64 Female 1/17/2013 Physician Cy
Primary
Concomitant
Wrist Fracture Other Serious 5/31/2012 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Weight Decreased Other Serious 10/16/2012 58 Female 150 lb 1/19/2013 Consumer Us
Primary
Concomitant
Multi-organ Failure Death 1/2013 71 Male 2/27/2013 Physician De
Primary
Concomitant
Thrombocytopenia Hospitalization 1/7/2013 Female 190 lb 2/11/2013 Physician De
Primary
Concomitant
Vomiting Hospitalization 1/17/2013 Female 282 lb 8/1/2013 Physician De
Primary
Concomitant
Pleural Effusion Other Serious Male 3/19/2013 Physician Us
Primary
Secondary
Concomitant
Gastric Ulcer Perforation Life Threatening 1/2013 Female 2/11/2013 Other Health Professional Us
Primary
Concomitant
Death Death Female 2/11/2013 Consumer Us
Primary
Concomitant
Syncope Other Serious 2/2/2013 50 Female 161 lb 2/12/2013 Physician Us
Primary
Concomitant
Vomiting Life Threatening 2/7/2013 64 Female 192 lb 3/7/2013 Physician Us
Primary
Concomitant
Hiatus Hernia Hospitalization 2/20/2013 74 Female 149 lb 5/31/2013 Physician Es
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/16/2013 48 Female 2/19/2013 Pharmacist Us
Primary
Concomitant
Respiratory Failure Death 2/2013 Female 4/17/2013 Physician De
Primary
Concomitant
Febrile Neutropenia Death 3/26/2012 Male Other Health Professional Us
Primary
Secondary
Concomitant
Partial Seizures Hospitalization 2/20/2013 Female 152 lb 6/5/2013 Other Health Professional De
Primary
Concomitant
Stomatitis Other Serious Female 138 lb 1/22/2013 Consumer Us
Primary
Concomitant
Death Death 2/15/2013 60 Female 2/28/2013 Consumer Us
Primary
Concomitant
Vomiting Death 12/1/2012 86 Female 121 lb 3/1/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 1/2/2013 Female 132 lb 7/22/2013 Physician De
Primary
Concomitant
Hypokalaemia Hospitalization 2/2013 Female 3/5/2013 Physician Fr
Primary
Secondary
Palpitations Hospitalization NotSpecified 3/5/2013 Physician Us
Primary
Secondary
Tachycardia Hospitalization 2/20/2013 Female 154 lb 3/19/2013 Physician De
Primary
Concomitant
Pulmonary Oedema Hospitalization 1/23/2013 74 Female 120 lb 3/7/2013 Other Health Professional Us
Primary
Concomitant
Weight Decreased Other Serious 1/7/2013 90 Female 142 lb 3/8/2013 Consumer Us
Primary
Concomitant
Stomatitis Hospitalization 2/25/2013 Female 201 lb 8/16/2013 Other Health Professional De
Primary
Concomitant
Eosinophilic Pneumonia Hospitalization 12/25/2012 47 Female 3/19/2013 Physician Fr
Primary
Secondary
Vomiting Other Serious 11/21/2012 62 Female 3/21/2013 Physician Ar
Primary
Concomitant
Stomatitis Hospitalization 10/16/2012 Female 10/31/2012 Physician Us
Primary
Concomitant
Toxicity To Various Agents Other Serious 81 Female 3/27/2013 Physician Us
Primary
Concomitant
Myelitis Transverse Other Serious Female 3/28/2013 Physician Gb
Primary
Secondary
Pneumonia Hospitalization Female 165 lb 6/27/2013 Other Health Professional De
Primary
Concomitant
Musculoskeletal Pain Hospitalization 3/26/2013 Female 137 lb 4/25/2013 Other Health Professional Nl
Primary
Concomitant
Vision Blurred Other Serious 3/1/2013 60 Female 4/3/2013 Physician Us
Primary
Concomitant
Gastroenteritis Viral Hospitalization 3/29/2013 59 Female 5/7/2013 Physician It
Primary
Secondary
Myelitis Transverse Other Serious Female 4/5/2013 Physician Gb
Primary
Secondary
Renal Impairment Other Serious Female 5/14/2013 Physician Co
Primary
Concomitant
Stomatitis Other Serious 3/5/2013 54 Female 143 lb 4/16/2013 Physician Country Not Specified
Primary
Concomitant
Respiratory Depression Hospitalization 3/28/2013 56 Female 4/22/2013 Physician Ca
Primary
Concomitant
Somnolence Hospitalization 3/25/2013 NotSpecified 9/20/2013 Physician It
Primary
Secondary
Concomitant
Renal Failure Acute Death 3/25/2013 NotSpecified 4/17/2013 Physician Es
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 3/28/2013 51 Female 148 lb 4/24/2013 Physician Be
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death Female 5/28/2013 Consumer Ca
Primary
Concomitant
Tachypnoea Other Serious 3/2013 Female 219 lb 9/30/2013 Physician De
Primary
Concomitant
Vomiting Other Serious 4/16/2013 Female 139 lb 7/8/2013 Physician De
Primary
Concomitant
Skin Exfoliation 2013 47 Female 161 lb 8/16/2013 Consumer Us
Primary
Secondary
Hyponatraemia Other Serious 4/15/2013 59 Female 134 lb 6/6/2013 Physician No
Primary
Concomitant
Skin Discolouration Other Serious 4/21/2013 66 Female 176 lb 5/4/2013 Physician Sa
Primary
Concomitant
Renal Failure Life Threatening 72 Female 152 lb 5/6/2013 Physician Us
Primary
Concomitant
Rash Other Serious 2/11/2013 83 Female 112 lb 5/7/2013 Physician It
Primary
Secondary
Concomitant
Pruritus 62 Female 126 lb 6/20/2013 Consumer Us
Primary
Concomitant
Pleural Effusion Other Serious Female 6/5/2013 Physician It
Primary
Secondary
General Physical Health Deterioration Hospitalization 4/22/2013 Female 179 lb 5/17/2013 Physician De
Primary
Concomitant
Rash 10/30/2012 60 Female 115 lb 12/3/2012 Consumer Us
Primary
Secondary
Concomitant
Gastrointestinal Obstruction Hospitalization 5/13/2013 Female 150 lb 6/4/2013 Physician De
Primary
Concomitant
Pruritus Other Serious 5/5/2013 62 Female 123 lb 5/31/2013 Consumer Us
Primary
Concomitant
Small Intestinal Obstruction Death 3/8/2013 73 Female 6/27/2013 Consumer Us
Primary
Secondary
Mouth Ulceration Other Serious 4/4/2013 72 Female 7/10/2013 Physician Au
Primary
Concomitant
Rectal Haemorrhage Hospitalization 4/19/2013 NotSpecified 9/6/2013 Physician It
Primary
Secondary
Pneumonia Hospitalization 5/23/2013 Female 110 lb 8/28/2013 Other Health Professional De
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/14/2013 Female 165 lb 6/7/2013 Physician De
Primary
Concomitant
Pyrexia Hospitalization 5/2013 Female 108 lb 7/2/2013 Physician De
Primary
Concomitant
Pneumonitis Other Serious 2/2013 82 Female 6/10/2013 Physician Gb
Primary
Secondary
Malignant Neoplasm Progression Other Serious Female 8/16/2013 Physician Ch
Primary
Concomitant
Nausea Hospitalization 6/3/2013 Female 112 lb 9/17/2013 Other Health Professional De
Primary
Concomitant
Malignant Neoplasm Progression Death 6/10/2013 82 Female 136 lb 9/2/2013 Physician Gb
Primary
Concomitant
Thrombocytopenia Life Threatening 5/15/2013 Female 238 lb 6/27/2013 Other Health Professional De
Primary
Concomitant
Proteinuria Other Serious 5/3/2013 47 Female 179 lb 8/21/2013 Physician Us
Primary
Concomitant
Death Death 6/21/2013 83 Female 134 lb 7/2/2013 Physician Es
Primary
Secondary
Concomitant
Stomatitis Hospitalization Female 7/31/2013 Consumer Us
Primary
Concomitant
Swollen Tongue Hospitalization 4/4/2013 74 Female 187 lb 6/28/2013 Physician De
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious Female 7/1/2013 Physician Us
Primary
Concomitant
General Physical Health Deterioration Hospitalization 6/24/2013 Female 159 lb 8/19/2013 Other Health Professional De
Primary
Concomitant
Toothache Other Serious Female 208 lb 7/2/2013 Physician Us
Primary
Secondary
Metastases To Liver Death 6/11/2013 72 Female 7/10/2013 Physician Au
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 6/26/2013 NotSpecified 8/1/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Hypertensive Crisis Other Serious 5/13/2013 Female 168 lb 7/4/2013 Physician De
Primary
Secondary
Weight Decreased Other Serious 5/13/2013 66 Female 118 lb 7/5/2013 Physician Us
Primary
Concomitant
General Physical Health Deterioration Death 6/25/2013 NotSpecified 9/25/2013 Physician It
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 2/21/2013 Female 9/4/2013 Physician De
Primary
Concomitant
Hepatic Failure Death 6/27/2013 NotSpecified 8/5/2013 Physician It
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious NotSpecified 7/9/2013 Physician Nl
Primary
Concomitant
Malignant Neoplasm Progression Life Threatening 4/19/2013 Female 7/15/2013 Other Health Professional De
Primary
Concomitant
Blood Creatinine Increased Other Serious 1/3/2013 Female 132 lb 7/10/2013 Physician De
Primary
Secondary
Concomitant
Arrhythmia Hospitalization 7/1/2013 Female 141 lb 7/15/2013 Other Health Professional De
Primary
Concomitant
Tongue Eruption Other Serious 12/2012 Female 119 lb 9/20/2013 Physician De
Primary
Secondary
Stomatitis Other Serious 3/5/2013 72 Female 7/11/2013 Physician Us
Primary
Concomitant
Liver Disorder Death 5/2/2013 77 Female 99 lb 7/23/2013 Physician Es
Primary
Secondary
Hyponatraemia Hospitalization 7/8/2013 67 Female 119 lb 7/15/2013 Physician Be
Primary
Secondary
Gastrointestinal Disorder Other Serious 6/28/2013 Female 141 lb 8/6/2013 Physician De
Primary
Concomitant
Urinary Tract Infection Hospitalization 7/9/2013 Female 192 lb 9/18/2013 Physician De
Primary
Concomitant
Malignant Neoplasm Progression Death 6/26/2013 Female 8/14/2013 Physician De
Primary
Concomitant
Palpitations Hospitalization 6/24/2013 64 Female 187 lb 7/15/2013 Physician It
Primary
Secondary
Respiratory Distress Other Serious 7/14/2013 Female 192 lb 7/31/2013 Physician De
Primary
Concomitant
Drug Ineffective 6/13/2013 48 Female 7/24/2013 Pharmacist Us
Primary
Concomitant
Thrombocytopenia Death 7/2013 Female 121 lb 9/10/2013 Physician De
Primary
Secondary
Concomitant
Pulmonary Sarcoidosis Other Serious NotSpecified 8/1/2013 Other Health Professional Us
Primary
Concomitant
Vomiting Hospitalization 7/9/2013 57 NotSpecified 8/14/2013 Physician Be
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 7/1/2013 68 Female 198 lb 9/6/2013 Consumer Us
Primary
Concomitant
Rash Other Serious NotSpecified 8/2/2013 Physician Br
Primary
Secondary
Vomiting Death Female 139 lb 9/2/2013 Consumer Us
Primary
Concomitant
Vomiting Hospitalization 8/1/2013 66 Female 8/28/2013 Physician Au
Primary
Concomitant
Hepatic Mass Other Serious 7/2013 82 Female 99 lb 8/22/2013 Consumer Country Not Specified
Primary
Concomitant
Weight Decreased Other Serious 39 Female 134 lb 8/7/2013 Consumer Us
Primary
Concomitant
Pharyngeal Oedema Hospitalization Female 8/12/2013 Consumer Country Not Specified
Primary
Concomitant
Pain In Extremity Other Serious 2/4/2013 59 Female 125 lb 3/5/2013 Consumer Us
Primary
Concomitant
Abdominal Pain Female 3/5/2013 Physician Us
Primary
Concomitant
Rash NotSpecified 3/5/2013 Us
Primary
Concomitant

Drug Data