Afinitor combined with Avastin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 7/9/2009 Male 160 lb 8/17/2009 Physician United States
Primary
Concomitant
Parkinson's Disease Other Serious Male 10/19/2009 Physician United States
Primary
Interacting
Pneumonitis Other Serious 11/21/2009 Male 148 lb 12/10/2009 Physician United States
Primary
Secondary
Concomitant
Toothache Hospitalization 11/1/2009 Male 205 lb 12/11/2009 Physician Belgium
Primary
Secondary
Nausea Other Serious 5/28/2009 Male 254 lb 12/18/2009 Physician Germany
Primary
Secondary
Concomitant
Vomiting Life Threatening 9/29/2009 Male 157 lb 12/23/2009 Physician Belgium
Primary
Secondary
Concomitant
Pneumonitis Other Serious 11/21/2009 Male 206 lb 12/23/2009 Physician United States
Primary
Secondary
Concomitant
Vena Cava Filter Insertion Hospitalization 10/30/2009 Male 152 lb 12/29/2009 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization Male 1/5/2010 Physician Greece
Primary
Concomitant
Oedema Peripheral Hospitalization 1/6/2010 Male 221 lb 1/13/2010 Physician United States
Primary
Secondary
Concomitant
Toothache Hospitalization 11/1/2009 Male 205 lb 1/13/2010 Physician Belgium
Primary
Secondary
Vena Cava Filter Insertion Hospitalization 10/30/2009 Male 152 lb 1/28/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vena Cava Filter Insertion Hospitalization 1/6/2010 Male 221 lb 1/28/2010 Physician United States
Primary
Secondary
Concomitant
Toothache Hospitalization 11/1/2009 Male 205 lb 1/28/2010 Physician Belgium
Primary
Secondary
Syncope Death 1/24/2010 Female 123 lb 2/1/2010 Physician Czech Republic
Primary
Secondary
Vomiting Hospitalization 10/30/2009 Male 210 lb 2/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonitis Hospitalization 11/21/2009 Male 206 lb 2/4/2010 Physician United States
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 12/9/2009 Male 2/8/2010 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/9/2010 Female 204 lb 2/17/2010 Physician United States
Primary
Secondary
Concomitant
Sigmoiditis Hospitalization 10/24/2009 Male 172 lb 2/19/2010 Physician France
Primary
Secondary
Weight Decreased Hospitalization 11/1/2009 Male 205 lb 2/22/2010 Physician Belgium
Primary
Secondary
Vena Cava Filter Insertion Hospitalization 2/13/2010 Male 170 lb 2/24/2010 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 2/10/2010 Male 192 lb 2/24/2010 Physician Czech Republic
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/9/2010 Female 204 lb 3/1/2010 Physician United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 2/10/2010 Male 192 lb 3/4/2010 Physician Czech Republic
Primary
Secondary
Concomitant
Vena Cava Filter Insertion Hospitalization 2/13/2010 Male 170 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Vena Cava Filter Insertion Hospitalization 1/6/2010 Male 221 lb 3/8/2010 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Death 3/1/2010 Female 128 lb 3/8/2010 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/9/2010 Female 204 lb 3/12/2010 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/9/2010 Male 170 lb 3/17/2010 Physician United States
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 2/10/2010 Male 192 lb 3/17/2010 Physician Czech Republic
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 3/10/2010 73 Female 148 lb 3/19/2010 Physician Germany
Primary
Secondary
Weight Decreased Other Serious 2/4/2010 Female 3/25/2010 United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/9/2010 Female 204 lb 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Tremor Other Serious 4/1/2010 70 Female 5/12/2010 Physician Greece
Primary
Concomitant
Haemoglobin Decreased Hospitalization Female 5/12/2010 Physician Italy
Primary
Secondary
Vena Cava Filter Insertion Hospitalization 2/13/2010 48 Male 170 lb 5/13/2010 Physician United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/9/2010 48 Male 170 lb 5/13/2010 Physician United States
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 6/20/2009 70 Female 108 lb 5/17/2010 Physician France
Primary
Secondary
Leukopenia Hospitalization 5/4/2010 66 Female 5/19/2010 Physician Italy
Primary
Secondary
Tumour Necrosis Hospitalization 5/10/2010 16 Female 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/9/2010 52 Female 204 lb 5/24/2010 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 3/1/2010 62 Female 128 lb 5/28/2010 Physician United States
Primary
Secondary
Concomitant
Wheezing Other Serious 4/19/2009 67 Male 430 lb 6/1/2010 Consumer United States
Primary
Secondary
Concomitant
Leukopenia Hospitalization 5/4/2010 66 Female 6/3/2010 Physician Italy
Primary
Secondary
Vena Cava Filter Insertion Hospitalization 2/13/2010 48 Male 170 lb 6/3/2010 Physician United States
Primary
Secondary
Concomitant
Subileus Hospitalization 4/25/2010 55 Male 137 lb 6/8/2010 Physician Germany
Primary
Secondary
Stomatitis Hospitalization 4/26/2010 75 Male 120 lb 6/15/2010 Physician Singapore
Primary
Secondary
Vomiting Hospitalization 4/26/2010 56 Female 202 lb 6/18/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Hospitalization 10/22/2009 64 Male 194 lb 6/23/2010 Physician Spain
Primary
Secondary
Concomitant
Stomatitis Hospitalization 4/26/2010 75 Male 120 lb 6/29/2010 Physician Singapore
Primary
Secondary
Death Hospitalization 6/22/2010 66 Male 165 lb 6/29/2010 Physician United States
Primary
Secondary
Vomiting Hospitalization 5/4/2010 66 Female 7/7/2010 Physician Italy
Primary
Secondary
Swelling Other Serious 6/23/2010 65 Male 194 lb 7/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Chronic Hospitalization 6/9/2010 84 Male 141 lb 7/8/2010 Physician Germany
Primary
Secondary
Somnolence Hospitalization 6/15/2010 58 Male 168 lb 7/15/2010 Other Health Professional United States
Primary
Secondary
Somnolence Hospitalization 6/15/2010 58 Male 168 lb 7/21/2010 Other Health Professional United States
Primary
Secondary
Vomiting Hospitalization 7/7/2010 66 Male 209 lb 7/21/2010 Physician United States
Primary
Secondary
Vomiting Hospitalization 7/11/2010 59 Male 7/21/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Decreased Appetite Other Serious 6/1/2010 Female 7/23/2010 Physician Hong Kong
Primary
Secondary
Wheezing Other Serious 4/19/2009 67 Male 430 lb 7/27/2010 Consumer United States
Primary
Secondary
Concomitant
Hypoglycaemia Hospitalization 7/5/2010 66 Male 143 lb 7/28/2010 Physician Hong Kong
Primary
Secondary
Concomitant
Respiratory Rate Increased Other Serious 6/6/2010 58 Male 170 lb 8/2/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 5/4/2010 66 Female 8/4/2010 Physician Italy
Primary
Secondary
Proteinuria Other Serious 6/1/2010 Female 8/6/2010 Physician Hong Kong
Primary
Secondary
Urinary Tract Infection Other Serious 6/5/2010 81 Male 110 lb 8/9/2010 Physician Germany
Primary
Secondary
Proteinuria Other Serious 6/22/2010 Female 8/10/2010 Physician Hong Kong
Primary
Secondary
Urinary Tract Infection Other Serious 6/5/2010 81 Male 110 lb 8/12/2010 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/5/2010 66 Male 143 lb 8/20/2010 Physician Hong Kong
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/1/2010 46 Male 179 lb 8/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 6/9/2010 84 Male 141 lb 8/27/2010 Physician Germany
Primary
Secondary
Petechiae Hospitalization 7/27/2010 72 Male 190 lb 8/31/2010 Physician Netherlands
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/1/2010 46 Male 179 lb 8/31/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 9/29/2009 59 Male 157 lb 9/3/2010 Physician Belgium
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/30/2010 32 Female 136 lb 9/14/2010 Physician United States
Primary
Secondary
Concomitant
Interacting
Thrombocytopenia Hospitalization 7/5/2010 66 Male 143 lb 9/20/2010 Physician Hong Kong
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/11/2010 59 Male 9/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Proteinuria Other Serious 2/24/2010 62 Female 176 lb 9/27/2010 Physician Spain
Primary
Secondary
Vomiting Hospitalization 7/11/2010 59 Male 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Back Pain Hospitalization 9/29/2010 55 Female 179 lb 10/11/2010 Physician United States
Primary
Secondary
General Physical Health Deterioration Hospitalization 9/9/2010 69 Male 161 lb 10/12/2010 Physician Germany
Primary
Secondary
Vena Cava Filter Insertion Hospitalization 2/13/2010 48 Male 170 lb 10/14/2010 Physician United States
Primary
Secondary
Concomitant
Back Pain Hospitalization 9/29/2010 55 Female 179 lb 10/14/2010 Physician United States
Primary
Secondary
Proteinuria Other Serious 3/12/2010 62 Female 176 lb 10/20/2010 Physician Spain
Primary
Secondary
Renal Cancer Other Serious 6/22/2010 Female 10/22/2010 Physician Hong Kong
Primary
Secondary
Skin Discolouration Hospitalization 10/17/2010 58 Male 166 lb 10/26/2010 Physician United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 9/9/2010 69 Male 161 lb 11/2/2010 Physician Germany
Primary
Secondary
Skin Discolouration Hospitalization 10/17/2010 58 Male 166 lb 11/3/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/7/2010 66 Male 209 lb 11/8/2010 Physician United States
Primary
Secondary
Renal Cancer Other Serious 6/22/2010 Female 11/8/2010 Physician Hong Kong
Primary
Secondary
Vomiting Hospitalization 8/1/2010 46 Male 179 lb 12/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 11/23/2010 63 Male 167 lb 12/21/2010 Physician United States
Primary
Secondary
Rectal Haemorrhage Hospitalization 11/9/2009 64 Male 168 lb 1/6/2011 Physician Turkey
Primary
Secondary
Death Death 6/29/2010 64 Male 1/6/2011 Physician Turkey
Primary
Secondary
Cholecystectomy Hospitalization 12/9/2009 37 Male 1/27/2011 Physician United States
Primary
Secondary
Concomitant
Hepatic Encephalopathy Hospitalization 10/26/2010 72 Male 187 lb 2/4/2011 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 12/10/2010 Male 170 lb 2/16/2011 Physician United States
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 11/9/2009 64 Male 168 lb 2/17/2011 Physician Turkey
Primary
Secondary
Duodenal Ulcer Haemorrhage Hospitalization 10/26/2010 72 Male 187 lb 2/17/2011 Physician Germany
Primary
Secondary
Chest Pain Hospitalization 11/20/2010 42 Male 178 lb 2/9/2011 Physician United States
Primary
Secondary
Concomitant
Arteriospasm Coronary Hospitalization 11/20/2010 42 Male 178 lb 2/17/2011 Physician United States
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 9/29/2010 55 Female 179 lb 2/18/2011 Physician United States
Primary
Secondary
Headache Hospitalization 2/15/2011 81 Male 119 lb 3/4/2011 Physician Germany
Primary
Secondary
Concomitant
Hypercalcaemia Hospitalization 3/10/2011 59 Female 132 lb 3/17/2011 Physician Czech Republic
Primary
Secondary
Retroperitoneal Fibrosis Hospitalization 65 Male 3/18/2011 Physician Greece
Primary
Concomitant
Headache Hospitalization 2/15/2011 81 Male 119 lb 3/18/2011 Physician Germany
Primary
Secondary
Concomitant
Hypertension Hospitalization 6/20/2009 70 Female 108 lb 3/25/2011 Physician France
Primary
Secondary
Hypercalcaemia Hospitalization 3/10/2011 59 Female 132 lb 3/29/2011 Physician Czech Republic
Primary
Secondary
Headache Hospitalization 2/15/2011 81 Male 119 lb 3/30/2011 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 12/10/2010 Male 170 lb 3/31/2011 Physician United States
Primary
Secondary
Concomitant
Cardiovascular Disorder Hospitalization 2/15/2011 81 Male 119 lb 4/4/2011 Physician Germany
Primary
Secondary
Concomitant
Malaise Hospitalization 12/10/2010 Male 170 lb 4/4/2011 Physician United States
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 5/29/2010 60 Male 158 lb 4/13/2011 Physician Brazil
Primary
Secondary
Concomitant
Vasoconstriction Hospitalization 11/20/2010 42 Male 178 lb 4/18/2011 Physician United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 9/29/2009 59 Male 157 lb 4/26/2011 Physician Belgium
Primary
Secondary
Concomitant
Cardiovascular Disorder Death 2/15/2011 81 Male 119 lb 5/4/2011 Physician Germany
Primary
Secondary
Concomitant
Dehydration Hospitalization 4/26/2010 75 Male 119 lb 5/10/2011 Physician Singapore
Primary
Secondary
Cerebral Infarction Hospitalization 2/15/2011 81 Male 119 lb 5/12/2011 Physician Germany
Primary
Secondary
Concomitant
Convulsion Death 2/15/2011 81 Male 119 lb 5/17/2011 Physician Germany
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 11/9/2009 64 Male 168 lb 5/23/2011 Physician Turkey
Primary
Secondary
Disease Progression Death 3/1/2010 50 Female 5/27/2011 Physician Italy
Primary
Secondary
Abdominal Pain Hospitalization 5/4/2010 66 Female 5/31/2011 Physician Italy
Primary
Secondary
Vomiting Hospitalization 9/6/2008 58 Male 163 lb 5/31/2011 Physician Belgium
Primary
Secondary
Rectal Haemorrhage Hospitalization 11/9/2009 64 Male 168 lb 6/8/2011 Physician Turkey
Primary
Secondary
Febrile Neutropenia Hospitalization 6/2/2011 23 Female 108 lb 6/10/2011 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 6/2/2011 23 Female 108 lb 6/14/2011 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/29/2010 60 Male 158 lb 6/16/2011 Physician Brazil
Primary
Secondary
Concomitant
Pyrexia Other Serious 6/22/2010 65 Male 194 lb 7/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 6/2/2011 23 Female 108 lb 7/20/2011 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 6/2/2011 23 Female 108 lb 8/9/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 7/18/2011 43 Male 8/9/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Progression Death 7/26/2011 69 Male 147 lb 8/12/2011 Physician United States
Primary
Secondary
Concomitant
Confusional State Death 6/22/2010 65 Male 194 lb 8/17/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 4/26/2010 75 Male 119 lb 8/18/2011 Physician Singapore
Primary
Secondary
Febrile Neutropenia Hospitalization 8/11/2011 68 Male 235 lb 8/22/2011 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 8/11/2011 68 Male 235 lb 8/24/2011 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 10/8/2009 67 Male 152 lb 9/7/2011 Physician Belgium
Primary
Secondary
Rectal Haemorrhage Hospitalization 11/9/2009 64 Male 168 lb 9/6/2011 Physician Turkey
Primary
Secondary
Metastatic Renal Cell Carcinoma Death 6/29/2010 64 Male 9/6/2011 Physician Turkey
Primary
Secondary
Abdominal Hernia Hospitalization 6/26/2011 58 Male 222 lb 9/20/2011 Physician Russian Federation
Primary
Secondary
Muscular Weakness Hospitalization 9/6/2009 59 Male 163 lb 9/26/2011 Physician Belgium
Primary
Secondary
Ataxia Death 8/10/2011 68 Female 135 lb 10/25/2011 Physician United States
Primary
Secondary
Concomitant
Fistula Other Serious 6/26/2011 58 Male 222 lb 11/9/2011 Physician Russian Federation
Primary
Secondary
Arterial Thrombosis Hospitalization 10/17/2010 58 Male 166 lb 11/16/2011 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 9/1/2009 67 Male 152 lb 11/29/2011 Physician Belgium
Primary
Secondary
Haematoma Hospitalization 10/24/2011 64 Female 12/1/2011 Physician United States
Primary
Secondary
Cerebral Haemorrhage Death 8/10/2011 68 Female 135 lb 12/7/2011 Physician United States
Primary
Secondary
Concomitant
Concomitant Disease Progression Death 8/10/2011 68 Female 135 lb 12/8/2011 Physician United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 11/25/2011 63 Male 124 lb 12/8/2011 Physician United States
Primary
Concomitant
Toothache Hospitalization 11/1/2009 69 Male 205 lb 12/8/2011 Physician Belgium
Primary
Secondary

Drug Data