Acyclovir combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tumour Lysis Syndrome Required Intervention 10/14/2005 55 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Blood Creatinine Increased Required Intervention 10/10/2005 32 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Required Intervention 8/25/2005 61 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Required Intervention 11/9/2005 46 Male 11/15/2005 United States
Primary
Concomitant
Renal Failure Acute Required Intervention 10/29/2005 40 Female 11/15/2005 Other Health Professional United States
Primary
Concomitant
Renal Impairment Required Intervention 11/5/2005 54 Female 11/15/2005 Other Health Professional United States
Primary
Concomitant
Viral Pharyngitis Other Serious 1/1/2000 51 Male 231 lb 1/27/2006 Physician United States
Primary
Secondary
Concomitant
Hepatitis Fulminant Other Serious Unknown 1/31/2006 Germany
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious Unknown 1/31/2006 Germany
Primary
Secondary
Concomitant
Post Procedural Complication Death 34 Male 2/7/2006 Physician Japan
Primary
Concomitant
Hemiplegia Death 34 Male 2/16/2006 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 1/1/2004 60 Male 236 lb 2/24/2006 Physician United States
Primary
Concomitant
Viral Pharyngitis Other Serious 1/1/2000 51 Male 231 lb 3/1/2006 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/1/2004 60 Male 236 lb 3/1/2006 Physician United States
Primary
Concomitant
Transplant Rejection Other Serious 6/27/2005 1 Male 19 lb 3/17/2006 Japan
Primary
Secondary
Concomitant
Thrombosis Hospitalization 6/6/2000 43 Female 205 lb 3/20/2006 Physician United States
Primary
Concomitant
Viral Pharyngitis Other Serious 1/1/2000 51 Male 231 lb 3/21/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/1/2006 Male 168 lb 3/28/2006 Physician Germany
Primary
Concomitant
Stem Cell Transplant Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Renal Failure Hospitalization 8/25/2005 61 Male 3/24/2006 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2002 52 Female 121 lb 4/24/2006 Physician United States
Primary
Concomitant
Thrombosis Hospitalization 6/6/2000 43 Female 205 lb 4/27/2006 Physician United States
Primary
Concomitant
Ventricular Hypertrophy Life Threatening 3/27/2006 Female 116 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 1/1/2000 51 Male 231 lb 5/9/2006 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/1/2004 57 Male 236 lb 5/17/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/20/2006 70 Female 117 lb 5/11/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/23/2006 Physician Germany
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Right Ventricular Failure Death 2/26/2006 Female 101 lb 6/7/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 6/7/2006 Physician Germany
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Death 34 Male 5/23/2006 Physician Japan
Primary
Concomitant
Rash Other Serious 1/1/2006 59 Female 205 lb 4/20/2006 United States
Primary
Concomitant
Streptococcal Infection Hospitalization 6/7/2006 Male 135 lb 6/8/2006 United States
Primary
Secondary
Concomitant
Vaginal Exfoliation Hospitalization 5/23/2006 Female 139 lb 7/13/2006 Physician United Kingdom
Primary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 7/3/2003 35 Female 8/24/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 35 Male 9/5/2006 Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 35 Male 9/5/2006 Physician Japan
Primary
Secondary
Concomitant
Increased Tendency To Bruise 6/7/2006 47 Female 139 lb 10/2/2006 Consumer United States
Primary
Concomitant
Yellow Skin Other Serious 1/1/2004 30 Female 10/11/2006 Other Health Professional India
Primary
Concomitant
Pneumomediastinum Other Serious 35 Male 10/11/2006
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 55 Female 10/5/2006 Germany
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 31 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 2/25/2006 42 Male 165 lb 10/24/2006 Physician Japan
Primary
Concomitant
Hospitalisation Other Serious 1/19/2006 Female 179 lb 11/20/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 11/1/2005 Female 179 lb 12/12/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 11/9/2005 46 Male 10/7/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 10/29/2005 40 Female 10/7/2006 Other Health Professional United States
Primary
Concomitant
Vasculitis Death 15 Male 2/6/2007 Physician Canada
Primary
Secondary
Concomitant
Vasculitis Death 15 Male 2/12/2007 Physician Canada
Primary
Secondary
Concomitant
Skin Lesion Other Serious 0 Male 2/15/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 12/20/2006 18 Male 2/20/2007 United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 12/20/2006 18 Male 2/24/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancytopenia Death 3/10/2007 37 Female 165 lb 3/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Palpitations 54 Female 196 lb 3/27/2007 Consumer United States
Primary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Meningitis Bacterial Hospitalization 63 Male 4/7/2007 Physician Japan
Primary
Concomitant
Somnolence Other Serious 54 Male 4/18/2007 Physician Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 3/22/2005 38 Female 123 lb 4/24/2007 Physician Japan
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 3/22/2005 38 Female 123 lb 4/24/2007 Physician Japan
Primary
Secondary
Concomitant
Scedosporium Infection Death 11/1/2001 43 Male 4/24/2007 Physician United States
Primary
Secondary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
Wound Drainage Death 11/1/2001 43 Male 5/9/2007 Physician United States
Primary
Secondary
Concomitant
Serum Ferritin Increased Other Serious 12/12/2005 50 Female 141 lb 5/23/2007 Physician United States
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/15/2007 59 Male 234 lb 5/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Tremor 11/30/2006 54 Female 3/13/2007 Consumer United States
Primary
Concomitant
Venous Haemorrhage Death 42 Male 6/1/2007 Greece
Primary
Secondary
Concomitant
Mucous Membrane Disorder Other Serious 57 Female 6/13/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7/21/2006 54 Male 157 lb 6/12/2007 Physician Japan
Primary
Concomitant
Palpitations 2/23/2007 54 Female 196 lb 6/25/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 6/15/2007 Male 220 lb 6/26/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/3/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/27/2006 30 Female 90 lb 7/12/2007 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Vomiting Other Serious 14 Male 8/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 14 Male 8/30/2007 United Kingdom
Primary
Concomitant
Tremor Hospitalization 8/15/2007 Female 227 lb 9/4/2007 United States
Primary
Secondary
Concomitant
Oesophageal Stenosis Other Serious 3 Female 9/7/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Peroneal Nerve Palsy Hospitalization 8/15/2007 Female 227 lb 9/6/2007 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Rash Papular 7/17/2007 58 Male 205 lb 9/26/2007 Consumer United States
Primary
Concomitant
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
Vomiting Other Serious 14 Female 10/2/2007
Primary
Secondary
Concomitant
Tremor Hospitalization 8/15/2007 Female 227 lb 10/4/2007 United States
Primary
Secondary
Concomitant
Pericarditis Fungal Other Serious 11/11/2005 3 Female 10/23/2007
Primary
Secondary
Concomitant
Herpes Simplex Hospitalization 57 Male 10/25/2007
Primary
Secondary
Concomitant
Meningitis Aseptic Hospitalization 62 Male 10/25/2007
Primary
Secondary
Concomitant
Vasculitis Other Serious 15 Male 11/5/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 9/1/2007 Male 11/9/2007 Physician United States
Primary
Concomitant
Urine Analysis Abnormal Other Serious 53 Male 11/13/2007 Other Health Professional Portugal
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 76 Female 11/19/2007
Primary
Secondary
Concomitant
Vomiting Other Serious 14 Male 11/19/2007
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 9 Male 11/21/2007 Sweden
Primary
Secondary
Concomitant
Renal Tubular Necrosis Other Serious 53 Male 12/6/2007 Other Health Professional Portugal
Primary
Secondary
Periarthritis Other Serious 10/16/2007 57 Female 12/11/2007 Physician United States
Primary
Concomitant
Renal Tubular Necrosis Other Serious 53 Male 12/12/2007 Other Health Professional Portugal
Primary
Secondary
Venous Thrombosis Other Serious 53 Male 12/7/2007 Physician Portugal
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 37 Male 12/14/2007 Consumer Turkey
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 37 Male 12/20/2007 Physician Turkey
Primary
Concomitant
Mucosal Inflammation Hospitalization 37 Male 12/28/2007 Physician Turkey
Primary
Concomitant
Toxoplasma Serology Positive Other Serious 2/1/2007 56 Female 12/28/2007 Other Health Professional Germany
Primary
Concomitant
Vomiting Other Serious 14 Male 1/8/2008 United Kingdom
Primary
Concomitant
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 9/24/2007 46 Female 146 lb 1/24/2008 United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 60 Female 1/25/2008 Other Health Professional United States
Primary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 33 Male 2/15/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/18/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
No Therapeutic Response Death 33 Male 2/19/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Infection Death 2/19/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 53 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 27 Female 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Chronic Myeloid Leukaemia Death 57 Male 2/20/2008 Other Health Professional Mexico
Primary
Secondary
Concomitant
Adenocarcinoma Death 2/21/2008 Canada
Primary
Secondary
Concomitant
Sepsis Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Arrhythmia Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Encephalopathy Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 2/22/2008 Canada
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 2/5/2008 3 Male 29 lb 2/26/2008 Other Health Professional Canada
Primary
Concomitant
Graft Versus Host Disease Death 33 Male 3/10/2008 Mexico
Primary
Concomitant
Chronic Graft Versus Host Disease Death 15 Male 3/10/2008 Mexico
Primary
Concomitant

Drug Data