Actos combined with Metformin Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Oedema Life Threatening 1/12/2006 62 Male 1/24/2006 Physician Japan
Primary
Concomitant
Fat Tissue Increased Hospitalization 12/15/2003 53 Female 1/25/2006 Netherlands
Primary
Concomitant
Cerebrovascular Accident Hospitalization 5/18/2004 53 Female 243 lb 2/2/2006 Physician United States
Primary
Concomitant
Infarction Required Intervention 2/2/2006 Male 185 lb 2/2/2006 Physician United States
Primary
Concomitant
Syncope Hospitalization 1/23/2006 Female 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Discolouration Other Serious 12/12/2005 66 Female 146 lb 2/9/2006 Physician United States
Primary
Concomitant
Pulmonary Oedema Life Threatening 1/12/2006 62 Male 2/16/2006 Japan
Primary
Concomitant
Thrombosis Other Serious 11/23/2003 61 Male 256 lb 3/1/2006 Lawyer United States
Primary
Concomitant
Injury Hospitalization 9/11/2003 66 Male 218 lb 3/9/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 9/11/2003 66 Male 218 lb 3/17/2006 Physician United States
Primary
Concomitant
Skin Reaction 1/1/2005 Male 1/20/2006 Physician United States
Primary
Concomitant
Sepsis Other Serious 7/25/2005 63 Male 3/27/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Sinus Bradycardia Other Serious 11/27/2003 61 Male 256 lb 3/30/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 6/1/2002 43 Female 196 lb 4/20/2006 Lawyer United States
Primary
Concomitant
Tremor Hospitalization 1/1/2003 52 Female 295 lb 4/21/2006 Physician United States
Primary
Concomitant
Malignant Melanoma Other Serious 6/16/2001 52 Male 209 lb 4/24/2006 Lawyer United States
Primary
Concomitant
Sepsis Other Serious 7/25/2005 63 Male 4/27/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/1/2001 52 Male 209 lb 5/1/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Hospitalization 4/1/2003 52 Male 199 lb 4/24/2006 Physician United States
Primary
Concomitant
Renal Cell Carcinoma Stage Unspecified Death 1/1/2004 38 Male 284 lb 5/10/2006 Lawyer United States
Primary
Concomitant
Dyspnoea Other Serious 3/6/2006 75 Male 335 lb 5/12/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 12/1/2005 Female 12/12/2005 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 3/31/2006 Female 5/26/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonitis Hospitalization 4/1/2006 78 Male 192 lb 5/30/2006 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 3/31/2006 Female 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Nausea 1/1/2006 37 Female 250 lb 4/17/2006 Consumer United States
Primary
Concomitant
Urticaria 3/1/2006 49 Female 4/17/2006 Physician United States
Primary
Concomitant
Dyspnoea Other Serious 3/6/2006 75 Male 335 lb 7/6/2006 Consumer United States
Primary
Concomitant
Tremor Hospitalization 1/1/2003 52 Female 295 lb 8/7/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 12/25/2005 Male 165 lb 11/27/2006 Physician Australia
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 12/25/2005 Male 165 lb 12/5/2006 Physician Australia
Primary
Secondary
Concomitant
Bradycardia Hospitalization 12/21/2006 70 Male 2/5/2007 Japan
Primary
Concomitant
Atrioventricular Block Second Degree Life Threatening 12/21/2006 72 Male 3/1/2007 Japan
Primary
Concomitant
Atrioventricular Block Second Degree Life Threatening 12/21/2006 72 Male 3/9/2007 Japan
Primary
Concomitant
Pericardial Effusion Hospitalization 3/9/2007 52 Male 3/30/2007 Japan
Primary
Concomitant
Pallanaesthesia Hospitalization 9/8/2006 24 Male 4/13/2007 Japan
Primary
Secondary
Pancreatitis Other Serious 1/30/2007 60 Male 5/14/2007 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2007 51 Male 5/18/2007 Japan
Primary
Concomitant
Anaemia Hospitalization 11/1/2006 80 Female 6/1/2007 Pharmacist Netherlands
Primary
Secondary
Leukopenia Other Serious 3/22/2007 49 Male 5/4/2007 Japan
Primary
Concomitant
Bone Marrow Failure Other Serious 3/22/2007 49 Male 7/3/2007 Japan
Primary
Concomitant
Ventricular Tachycardia Life Threatening 10/4/2005 73 Male 7/24/2007 Japan
Primary
Concomitant
Ventricular Tachycardia Life Threatening 10/4/2005 73 Male 8/30/2007 Japan
Primary
Concomitant
Cardiac Failure Congestive Life Threatening 5/13/2007 68 Male 10/1/2007 Japan
Primary
Concomitant
Palpitations 6/4/2007 67 Male 10/3/2007 Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 11/1/2007 63 Female 11/27/2007 United States
Primary
Secondary
Concomitant
Hepatic Steatosis Other Serious 1/1/2007 40 Male 12/11/2007 South Africa
Primary
Concomitant
Weight Decreased Hospitalization 6/25/2007 80 Female 12/28/2007 Japan
Primary
Secondary
Concomitant
Cardiac Failure Chronic Hospitalization 6/25/2007 80 Female 1/17/2008 Japan
Primary
Secondary
Concomitant
Macular Oedema Required Intervention 43 Female 2/7/2008 Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 11/1/2007 63 Female 3/10/2008 Other Health Professional United States
Primary
Concomitant
Hypertension 7/1/2007 3/13/2008 Consumer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 2/13/2008 64 Male 3/17/2008 Japan
Primary
Concomitant
Pitting Oedema Other Serious 4/17/2008 71 Male 5/14/2008 Other Health Professional Denmark
Primary
Concomitant
Uveitis Other Serious 33 Female 5/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Uveitis Required Intervention 33 Female 6/9/2008
Primary
Secondary
Concomitant
Pancreatitis Other Serious 1/30/2007 60 Male 7/10/2008 Physician United States
Primary
Concomitant
Renal Failure Chronic Other Serious 5/8/2007 Female 123 lb 7/16/2008 Japan
Primary
Secondary
Concomitant
Glossodynia 9/15/2007 Female 182 lb 7/25/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 5/8/2007 Female 123 lb 7/28/2008 Japan
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 5/4/2008 Female 7/23/2008 Japan
Primary
Concomitant
Weight Increased Male 8/4/2008 United States
Primary
Secondary
Therapeutic Response Unexpected Female 175 lb 8/27/2008 United States
Primary
Concomitant
White Blood Cell Count Increased Required Intervention 77 Female 9/26/2008 Other Health Professional United States
Primary
Concomitant
Pruritus Other Serious 1/1/2004 46 Male 312 lb 10/3/2008 United States
Primary
Concomitant
Gastrointestinal Ulcer Other Serious 1/1/2008 81 Female 130 lb 10/17/2008 Physician United States
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/17/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Memory Impairment Other Serious 5/7/2008 Female 10/17/2008 Consumer
Primary
Concomitant
Myocardial Infarction Hospitalization 3/25/2002 54 Male 226 lb 10/20/2008 Lawyer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 2/1/2007 53 Male 246 lb 10/20/2008 Consumer United States
Primary
Concomitant
Gastrointestinal Ulcer Other Serious 1/1/2008 81 Female 130 lb 10/20/2008 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 1/1/2008 Male 10/15/2008 Consumer United States
Primary
Concomitant
Influenza Like Illness Hospitalization 1/1/2008 Male 10/20/2008 Consumer United States
Primary
Concomitant
White Blood Cells Urine Positive Hospitalization 10/2/2008 Female 10/22/2008 Pharmacist United States
Primary
Concomitant
Restlessness Hospitalization 1/1/2008 Female 10/22/2008 Physician
Primary
Concomitant
Renal Failure Acute Hospitalization 9/29/2008 Female 198 lb 10/23/2008 United States
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Life Threatening 8/16/2008 65 Female 10/17/2008 Japan
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Life Threatening 8/15/2008 65 Female 10/29/2008 Japan
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 8/28/2008 Female 266 lb 12/17/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Death 1/1/2008 Male 195 lb 12/24/2008 Consumer United States
Primary
Concomitant
Urticaria Other Serious 12/9/2008 70 Male 236 lb 12/31/2008 Other Health Professional United States
Primary
Concomitant
Urticaria 12/9/2008 70 Male 236 lb 1/7/2009 Other Health Professional United States
Primary
Concomitant
Pulmonary Oedema Other Serious 79 Male 1/2/2009 Japan
Primary
Concomitant
Swollen Tongue Other Serious Male 250 lb 1/14/2009 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Death 1/1/2008 Male 195 lb 3/19/2009 Consumer United States
Primary
Concomitant
Total Lung Capacity Decreased Other Serious 1/1/2008 Male 203 lb 3/31/2009 Physician United States
Primary
Concomitant
Vertigo Hospitalization 3/17/2009 62 Male 4/6/2009 Japan
Primary
Concomitant
Vaginal Discharge Other Serious 1/1/2004 53 Female 190 lb 5/20/2009 United States
Primary
Concomitant
Pain Other Serious 5/10/2009 67 Male 210 lb 5/24/2009 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 12/23/2008 63 Male 230 lb 5/15/2009 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 11/1/2004 48 Male 220 lb 6/2/2009 Physician United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 3/21/2003 36 Female 188 lb 6/5/2009 United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 1/15/2004 66 Female 250 lb 6/5/2009 Physician United States
Primary
Concomitant
Rectal Cancer Other Serious 3/13/2009 Female 146 lb 6/8/2009 Physician United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 2/1/2007 53 Male 246 lb 6/8/2009 Consumer United States
Primary
Concomitant
Procedural Complication 6/1/2008 Female 230 lb 6/11/2009 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 11/12/2008 Female 192 lb 6/11/2009 Physician United States
Primary
Concomitant
Injection Site Pain 1/1/2008 Male 289 lb 6/11/2009 Consumer United States
Primary
Concomitant
Swelling Face 1/1/2009 Female 285 lb 6/12/2009 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis 1/1/2009 Female 178 lb 6/12/2009 Consumer United States
Primary
Concomitant
Joint Stiffness 12/1/2008 Male 230 lb 6/12/2009 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 10/30/2007 Male 293 lb 6/8/2009 Physician United States
Primary
Concomitant
Swelling Other Serious 4/10/2009 69 Male 154 lb 6/15/2009 Physician United States
Primary
Concomitant
Weight Increased 1/1/2006 Female 183 lb 6/9/2009 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 3/1/2009 Male 197 lb 6/15/2009 Consumer United States
Primary
Concomitant
Myalgia Male 200 lb 6/15/2009 Physician United States
Primary
Concomitant
Rhabdomyolysis Life Threatening 5/29/2009 68 Female 6/25/2009 Japan
Primary
Concomitant
Hepatic Function Abnormal Other Serious 2/3/2009 49 7/9/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 7/7/2006 47 Female 229 lb 7/14/2009 United States
Primary
Concomitant
Synovitis Other Serious 2/29/2000 37 Female 212 lb 7/28/2009 United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 2/3/2009 49 7/29/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Convulsion 6/1/2008 210 lb 8/6/2009 Other Health Professional United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 2/3/2009 49 8/13/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Somnolence 3/23/2008 66 Female 8/14/2009 Other Health Professional United States
Primary
Concomitant
No Adverse Event 5/8/2009 74 Female 129 lb 8/14/2009 Other Health Professional United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 7/17/2009 Male 9/3/2009 Consumer Switzerland
Primary
Concomitant
Vulvovaginal Mycotic Infection Other Serious 8/3/2003 44 Female 273 lb 9/23/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased 12/1/2000 50 Male 275 lb 9/23/2009 United States
Primary
Concomitant
Ventricular Fibrillation Hospitalization 65 Male 9/22/2009 United States
Primary
Concomitant
Unevaluable Event Hospitalization 12/1/2008 52 Female 9/21/2009 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious Male 206 lb 10/1/2009 Consumer United States
Primary
Secondary
Concomitant
Unevaluable Event Hospitalization 56 Male 9/23/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 46 Female 223 lb 9/25/2009 United States
Primary
Concomitant
Unemployment Hospitalization 1/20/2006 73 Male 163 lb 9/22/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 60 Female 9/29/2009 United States
Primary
Concomitant
Respiratory Failure Hospitalization 12/27/2006 Female 10/13/2009 Physician United States
Primary
Secondary
Concomitant
Rash Other Serious 2/1/2009 62 Female 212 lb 10/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 9/30/2009 72 Female 190 lb 10/13/2009 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 49 Male 206 lb 10/14/2009 Consumer United States
Primary
Secondary
Concomitant
Ill-defined Disorder Disability Male 194 lb 10/15/2009 Other Health Professional United States
Primary
Concomitant
Ill-defined Disorder Disability Female 215 lb 10/15/2009 United States
Primary
Concomitant
Ill-defined Disorder Disability Female 181 lb 10/16/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 9/1/2009 52 Female 10/16/2009 United States
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 9/1/2009 52 Female 10/16/2009 United States
Primary
Secondary
Concomitant
Irritable Bowel Syndrome 3/1/2009 Female 10/16/2009 Consumer
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Male 10/19/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/1/2001 52 Male 198 lb 10/22/2009 Physician United States
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 10/18/2009 11/5/2009 Physician Japan
Primary
Secondary
Hemiplegia Life Threatening 10/18/2009 47 Male 11/19/2009 Physician Japan
Primary
Concomitant
Asthma Other Serious 11/12/2009 Female 270 lb 12/1/2009 Physician United States
Primary
Concomitant
Tremor Hospitalization 9/10/2009 72 Female 11/23/2009 Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 8/28/2007 Female 230 lb 11/30/2009 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 204 lb 11/30/2009 Consumer United States
Primary
Concomitant
Respiratory Failure Hospitalization 9/22/2009 77 Male 154 lb 12/21/2009 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 9/22/2009 77 Male 154 lb 12/31/2009 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 9/22/2009 77 Male 154 lb 1/5/2010 Physician United States
Primary
Concomitant
Microalbuminuria Other Serious 12/1/2009 Male 1/6/2010 Physician Canada
Primary
Concomitant
Overdose 1/1/2006 64 Female 1/11/2010 Consumer United States
Primary
Secondary
Concomitant
Urticaria 43 Male 270 lb 1/11/2010 Consumer United States
Primary
Secondary
Concomitant

Drug Data