Activase combined with Heparin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Urinary Retention Hospitalization 3/9/2005 65 Male 137 lb 1/6/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Reperfusion Injury Other Serious 43 Male 2/7/2006 Switzerland
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 1/12/2006 43 Female 276 lb 2/17/2006 Pharmacist United States
Primary
Secondary
Weight Increased Hospitalization 5/22/2003 72 Female 121 lb 3/17/2006 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 2/20/2006 68 Male 3/24/2006 Physician France
Primary
Concomitant
Urinary Retention Hospitalization 3/9/2005 65 Male 137 lb 4/12/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2000 53 Male 351 lb 5/5/2006 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization 5/22/2003 72 Female 121 lb 5/3/2006 United States
Primary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2000 53 Male 351 lb 5/9/2006 Physician United States
Primary
Concomitant
Hypotension Required Intervention 1/26/2006 27 Female 3/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pseudomonas Infection Other Serious 1/1/2005 63 Female 102 lb 6/6/2006 Pharmacist United States
Primary
Concomitant
Drug Interaction Hospitalization 5/13/2006 87 Male 8/3/2006 Consumer France
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 5/13/2006 87 Male 8/25/2006 Consumer France
Primary
Concomitant
Interacting
Haemorrhage Intracranial Death 69 Female 12/11/2006 Physician United States
Primary
Secondary
Concomitant
Haemorrhage Intracranial Death 69 Female 1/4/2007 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective Death 1/10/2007 65 Male 1/22/2007 Other Health Professional India
Primary
Concomitant
Venous Thrombosis Hospitalization 11/2/2006 58 Male 4/11/2007 Physician Japan
Primary
Concomitant
Venous Thrombosis Hospitalization 11/2/2006 58 Male 4/17/2007 Physician Japan
Primary
Concomitant
Stevens-johnson Syndrome Life Threatening 7/15/2006 70 Male 5/21/2007 Consumer Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 72 Female 7/11/2007 Physician Germany
Primary
Concomitant
Death Death 6/1/2007 70 Male 7/13/2007 Physician Singapore
Primary
Concomitant
Drug Ineffective Other Serious 7/31/2007 Other Health Professional Germany
Primary
Secondary
Renal Infarct Other Serious 4/4/2006 68 Male 8/1/2007 Physician Japan
Primary
Concomitant
Pericardial Haemorrhage Death 57 Male 8/22/2007 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective Other Serious 9/6/2007 Other Health Professional Germany
Primary
Secondary
Renal Infarct Other Serious 4/4/2006 68 Male 9/6/2007 Physician Japan
Primary
Concomitant
Abdominal Pain Hospitalization 9/11/2007 50 Female 210 lb 9/14/2007 Consumer United States
Primary
Concomitant
Renal Infarct Other Serious 4/4/2006 68 Male 10/17/2007 Physician Japan
Primary
Concomitant
Peritonitis Bacterial Hospitalization 10/17/2007 67 Female 11/27/2007 United States
Primary
Concomitant
Gastrointestinal Haemorrhage Required Intervention 10/7/2007 80 Male 11/28/2007 Pharmacist United States
Primary
Secondary
Platelet Count Decreased Death 12/4/2007 Female 12/21/2007 Physician United States
Primary
Concomitant
Platelet Count Decreased Death 12/4/2007 Female 12/21/2007 Physician United States
Primary
Concomitant
Death Death 12/11/2007 26 Male 12/26/2007 Physician India
Primary
Concomitant
Hepatic Failure Death 19 Male 6/27/2008 Other Health Professional Germany
Primary
Concomitant
Death Death 69 Male 7/31/2008 Physician Germany
Primary
Secondary
Haemorrhagic Transformation Stroke Other Serious 59 Male 7/31/2008 Physician Germany
Primary
Secondary
Death Death 71 Female 7/31/2008 Physician Germany
Primary
Secondary
Death Death 69 Male 7/31/2008 Physician Germany
Primary
Secondary
Death Death 56 Male 7/31/2008 Physician Germany
Primary
Secondary
Swollen Tongue Hospitalization 65 Female 139 lb 8/6/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Post Procedural Complication Required Intervention 8/21/2008 77 Male 143 lb 9/24/2008 Pharmacist United States
Primary
Concomitant
Drug Ineffective Other Serious 81 Male 11/17/2008 Physician Germany
Primary
Concomitant
Drug Ineffective Disability 60 Female 12/11/2008 Other Health Professional Germany
Primary
Concomitant
Serotonin Syndrome Other Serious 11/25/2008 53 Male 158 lb 12/17/2008 Pharmacist United States
Primary
Secondary
Concomitant
Haemorrhage Intracranial Other Serious 70 Male 12/23/2008 Other Health Professional Germany
Primary
Secondary
Pneumonia Aspiration Other Serious 65 Male 126 lb 1/12/2009 Consumer India
Primary
Concomitant
Haemorrhage Intracranial Other Serious 1/5/2009 62 Male 132 lb 2/12/2009 Physician Germany
Primary
Concomitant
Peritonitis Bacterial Other Serious 53 Male 2/12/2009 Physician Germany
Primary
Secondary
Drug Ineffective Other Serious 77 Female 3/2/2009 Physician Germany
Primary
Concomitant
Stupor Other Serious 19 Female 3/26/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Headache Hospitalization 4/17/2009 84 Female 5/7/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Hypokinesia Other Serious 48 Male 5/13/2009 Other Health Professional Germany
Primary
Secondary
Thrombocytopenia Other Serious 5/13/2009 Physician Germany
Primary
Secondary
Concomitant
Serum Sickness Other Serious 5/13/2009 Physician Germany
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 5/13/2009 Germany
Primary
Secondary
Headache Hospitalization 4/17/2009 84 Female 5/14/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Peripheral Ischaemia Hospitalization 6 Male 57 lb 6/10/2009 Physician Australia
Primary
Concomitant
Therapeutic Response Decreased Other Serious Female 6/19/2009 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral Hospitalization 5/18/2009 Male 165 lb 6/30/2009 Physician France
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 36 Male 7/6/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Heparin-induced Thrombocytopenia Other Serious 38 Female 7/21/2009 Other Health Professional Poland
Primary
Concomitant
Multi-organ Failure Death 78 Male 8/3/2009 Physician Germany
Primary
Secondary
Vena Cava Thrombosis Other Serious 11 Female 150 lb 8/6/2009 Physician United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 78 Male 8/21/2009 Other Health Professional Germany
Primary
Secondary
Vitreous Haemorrhage Hospitalization Female 9/8/2009 Other Health Professional Germany
Primary
Secondary
Subcutaneous Haematoma Other Serious 9/8/2009 Physician Germany
Primary
Secondary
Puncture Site Haemorrhage Other Serious 9/17/2009 Physician Germany
Primary
Secondary
Vena Cava Thrombosis Other Serious 11 Female 150 lb 9/25/2009
Primary
Secondary
Splenic Rupture Hospitalization 18 Female 9/28/2009 Other Health Professional Germany
Primary
Secondary
Vena Cava Thrombosis Other Serious 11 Female 150 lb 10/1/2009 Other Health Professional Germany
Primary
Secondary
Hepatic Failure Death 9/19/2009 60 Male 10/15/2009 Pharmacist South Africa
Primary
Secondary
Concomitant
Catheter Site Haemorrhage Other Serious Male 9 lb 11/23/2009 Other Health Professional Germany
Primary
Secondary
Status Epilepticus Other Serious 49 Female 1/7/2010 Physician Germany
Primary
Secondary
Subcutaneous Haematoma Other Serious 26 Female 1/8/2010 Other Health Professional Germany
Primary
Secondary
Post Procedural Haematoma Other Serious 11/17/2009 Male 1/19/2010 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 7/1/2007 1 Male 18 lb 3/2/2010 Lawyer United States
Primary
Secondary
Concomitant
Death Death 7/2/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Required Intervention 7/1/2010 67 Male 253 lb 7/14/2010 Pharmacist United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 7/27/2010 United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 8/20/2010 United States
Primary
Concomitant
Wound Drainage Other Serious 2/1/2002 63 Male 140 lb 8/26/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/1/2003 42 Male 206 lb 9/3/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 10/1/2003 42 Male 206 lb 9/10/2010 Other Health Professional United States
Primary
Concomitant
Thrombosis In Device Other Serious 1/1/2010 74 Female 9/29/2010 Physician United States
Primary
Concomitant
Thrombosis In Device Other Serious 1/1/2010 74 Female 9/29/2010 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 10/1/2010 United States
Primary
Concomitant
Brain Oedema Death 10/14/2010 85 Male 11/9/2010 Physician Japan
Primary
Concomitant
Platelet Count Decreased Death 11/1/2010 67 Female 11/25/2010 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 12/2/2010 United States
Primary
Concomitant
Brain Oedema Death 10/14/2010 85 Male 12/10/2010 Physician Japan
Primary
Concomitant
Brain Oedema Death 10/14/2010 85 Male 12/17/2010 Physician Japan
Primary
Concomitant
Tooth Loss Other Serious 1/18/2005 51 Female 220 lb 1/12/2011 Lawyer United States
Primary
Secondary
Concomitant
Ischaemic Cardiomyopathy Hospitalization 82 Male 1/27/2011 United States
Primary
Concomitant
Compartment Syndrome Other Serious 2/25/2011 Other Health Professional Norway
Primary
Concomitant
Death Death 2/28/2011 Other Health Professional Norway
Primary
Concomitant
Gastrointestinal Disorder Hospitalization 1/1/1985 31 Female 220 lb 3/3/2011 Lawyer United States
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Death 1/23/2010 75 Male 161 lb 3/4/2011 Consumer United States
Primary
Concomitant
Peripheral Ischaemia Death 3/11/2011 Physician Sweden
Primary
Concomitant
No Therapeutic Response Other Serious 2/5/2011 0 Male 3 lb 3/22/2011 Physician United States
Primary
Concomitant
Diverticulitis Other Serious 11/2/2006 51 Female 214 lb 4/14/2011 United States
Primary
Secondary
Concomitant
Patent Ductus Arteriosus Other Serious 2/5/2011 0 Male 3 lb 4/14/2011 Physician United States
Primary
Concomitant
Sepsis Death 2/19/2007 89 Male 5/6/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Death 2/19/2007 89 Male 5/6/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Arteriosclerosis Other Serious 2/1/2002 63 Male 140 lb 5/3/2011 United States
Primary
Secondary
Concomitant
Haemoptysis Life Threatening 5/6/2006 71 Male 5/6/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Livedo Reticularis Other Serious 8/29/2007 49 Female 124 lb 6/9/2011 Consumer United States
Primary
Secondary
Concomitant
Haemorrhage Death 0 Male 3 lb 6/15/2011 Saudi Arabia
Primary
Concomitant
Haemorrhage Other Serious 6/16/2011 Other Health Professional Saudi Arabia
Primary
Concomitant
Haemorrhagic Stroke Hospitalization 4/23/2011 55 Female 6/20/2011 Consumer United States
Primary
Secondary
Concomitant
Nutritional Condition Abnormal Hospitalization 1/1/2003 48 Female 194 lb 6/24/2011 Physician United States
Primary
Secondary
Concomitant
Dysphagia Other Serious 1/1/2003 48 Female 194 lb 7/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Osteomyelitis Hospitalization 1/1/2003 48 Female 194 lb 8/3/2011 Lawyer United States
Primary
Secondary
Concomitant
Stress Fracture Hospitalization 1/1/2003 48 Female 194 lb 9/2/2011 Lawyer United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious Male 9/13/2011 Other Health Professional Germany
Primary
Concomitant
Angioedema Other Serious 65 Female 9/15/2011 Other Health Professional Turkey
Primary
Concomitant
Oliguria Other Serious 11/17/2010 82 Male 10/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death Male 10/20/2011 Physician Turkey
Primary
Secondary
Death Death Male 10/21/2011 Physician India
Primary
Concomitant
Depressed Level Of Consciousness Hospitalization 1/1/2003 48 Female 194 lb 10/28/2011 Lawyer United States
Primary
Secondary
Concomitant
Cough Death 8/22/2011 50 Male 11/1/2011 Physician Ukraine
Primary
Concomitant
Oedema Peripheral Other Serious 10/11/2011 46 Male 238 lb 11/8/2011 Consumer United States
Primary
Concomitant
Cough Death 8/6/2011 50 Male 11/8/2011 Physician Ukraine
Primary
Concomitant
Tongue Oedema Disability 3/31/2011 55 Female 12/2/2011 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 1/1/2011 12/19/2011 Other Health Professional United States
Primary
Concomitant
Ecchymosis Hospitalization Female 219 lb 12/12/2011 Lawyer United States
Primary
Concomitant
Phlebitis Hospitalization 5/16/2011 80 Male 1/2/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Blood Fibrinogen Abnormal Other Serious 9/11/2011 39 Female 1/13/2012 Pharmacist United States
Primary
Concomitant
Drug Ineffective Hospitalization 10/11/2011 46 Male 238 lb 1/20/2012 Pharmacist United States
Primary
Concomitant
Unevaluable Event Disability Female 216 lb 2/6/2012 Lawyer United States
Primary
Concomitant
Cerebral Haemorrhage Other Serious 3/20/2012 56 Male 3/27/2012 Physician Greece
Primary
Concomitant
Vomiting Hospitalization 75 Male 4/20/2012 Pharmacist United States
Primary
Concomitant
Cerebral Haemorrhage Other Serious 3/20/2012 57 Male 187 lb 5/4/2012 Physician Greece
Primary
Secondary
Concomitant
Pneumonia Other Serious 1/1/2001 40 Male 5/2/2012 Physician United States
Primary
Concomitant
Hypertension Other Serious 11 Female 150 lb 5/29/2012 Consumer United States
Primary
Secondary
Interacting
Hypertension Other Serious 11 Female 150 lb 6/19/2012 United States
Primary
Secondary
Interacting
Hepatic Vein Thrombosis Required Intervention 18 Female 6/5/2012 Physician United States
Primary
Concomitant
Intraventricular Haemorrhage Hospitalization 67 Male 6/26/2012 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 75 Female 7/10/2012 Physician United States
Primary
Secondary
Concomitant
Neurological Decompensation Other Serious Male 7/11/2012 Other Health Professional United States
Primary
Secondary
Death Death 61 Male 7/26/2012 Physician United States
Primary
Concomitant
Chest Pain Hospitalization Female 8/6/2012 Physician United States
Primary
Concomitant
Pathological Fracture Hospitalization 1/1/2003 48 Female 194 lb 8/8/2012 Physician United States
Primary
Secondary
Concomitant
Pain Other Serious 42 Female 8/8/2012 Physician United States
Primary
Concomitant
Cardiac Failure Death Male 8/9/2012 Physician United States
Primary
Concomitant
Atrial Fibrillation Other Serious 64 Male 8/9/2012 Physician United States
Primary
Concomitant
Dyspnoea Hospitalization 55 Male 8/10/2012 Physician United States
Primary
Concomitant
Hyperhidrosis Other Serious Male 8/10/2012 Physician United States
Primary
Concomitant
Accelerated Idioventricular Rhythm Hospitalization 51 Male 8/10/2012 Physician United States
Primary
Concomitant
Sensation Of Heaviness Hospitalization 5/30/1991 62 Male 8/10/2012 Physician United States
Primary
Concomitant
Pain Hospitalization Male 8/10/2012 Physician United States
Primary
Concomitant

Drug Data