Actemra combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Increased Other Serious 1/1/2008 Female 123 lb 9/25/2009 Consumer Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 Female 123 lb 10/16/2009 Consumer Brazil
Primary
Secondary
Concomitant
Septic Shock Life Threatening 1/1/2010 Female 104 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Polyarthritis Other Serious 12/1/2009 Female 1/27/2010 Physician Spain
Primary
Concomitant
Septic Shock Life Threatening 8/26/2009 Male 187 lb 2/1/2010 Physician Germany
Primary
Concomitant
Sepsis Hospitalization 8/1/2009 Male 154 lb 2/8/2010 Physician Brazil
Primary
Secondary
Concomitant
Oral Herpes Other Serious 9/15/2009 Female 176 lb 2/9/2010 Physician Austria
Primary
Concomitant
Pancreatitis Acute Hospitalization 11/1/2009 Female 2/11/2010 Physician Australia
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 1/20/2010 Female 99 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Myalgia Hospitalization 12/12/2009 63 Male 2/16/2010 Other Health Professional Sweden
Primary
Concomitant
Pruritus Other Serious Female 321 lb 2/17/2010 Consumer United States
Primary
Concomitant
Septic Shock Life Threatening 12/31/2009 Female 104 lb 2/23/2010 Physician Japan
Primary
Secondary
Concomitant
Death Death 1/24/2010 Female 2/25/2010 Other Health Professional Colombia
Primary
Concomitant
Cardiac Failure Death 3/1/2010 Male 132 lb 3/8/2010 Other Health Professional Belgium
Primary
Concomitant
Pruritus Other Serious Female 321 lb 3/15/2010 Physician United States
Primary
Concomitant
Thrombophlebitis Superficial Hospitalization 11/3/2009 Male 146 lb 3/16/2010 Physician France
Primary
Secondary
Concomitant
Convulsion Other Serious 3/5/2010 Female 176 lb 3/18/2010 Physician Honduras
Primary
Concomitant
Nervous System Neoplasm Benign Other Serious 12/1/2009 75 Female 3/19/2010 Physician Sweden
Primary
Concomitant
Thrombophlebitis Superficial Hospitalization 1/5/2010 Female 204 lb 3/22/2010 Consumer Spain
Primary
Concomitant
Ventricular Fibrillation Death 3/22/2010 33 Male 476 lb 3/26/2010 Physician Guatemala
Primary
Concomitant
Liver Function Test Abnormal Other Serious 1/25/2010 Male 220 lb 3/30/2010 Physician Australia
Primary
Concomitant
Septic Shock Death 3/1/2010 45 Female 3/30/2010 Consumer Belgium
Primary
Concomitant
Interstitial Lung Disease Hospitalization 4/3/2010 72 Female 4/16/2010 Physician Japan
Primary
Secondary
Gastritis Hospitalization 4/4/2010 40 Female 4/20/2010 Other Health Professional Colombia
Primary
Concomitant
Rash Hospitalization 5/15/2009 58 Female 106 lb 5/6/2010 Physician Japan
Primary
Concomitant
Gastritis Hospitalization 4/4/2010 40 Female 5/10/2010 Other Health Professional Colombia
Primary
Concomitant
Intestinal Perforation Other Serious 3/29/2010 61 Female 5/14/2010 Pharmacist Australia
Primary
Concomitant
Renal Impairment Hospitalization 3/1/2010 59 Female 131 lb 5/19/2010 Physician United States
Primary
Concomitant
Herpes Zoster Other Serious 5/8/2010 47 Female 235 lb 5/11/2010 Physician United States
Primary
Concomitant
Toothache Other Serious 2/1/2010 37 Female 145 lb 5/24/2010 Consumer Ecuador
Primary
Concomitant
Interstitial Lung Disease Hospitalization 4/3/2010 72 Female 5/25/2010 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 8/9/2009 54 Male 119 lb 5/28/2010 Physician Japan
Primary
Concomitant
Toothache Other Serious 2/1/2010 37 Female 145 lb 6/4/2010 Consumer Ecuador
Primary
Concomitant
Diarrhoea Hospitalization 66 Female 97 lb 6/11/2010 Other Health Professional Hong Kong
Primary
Concomitant
Diarrhoea Other Serious 66 Female 97 lb 6/23/2010 Other Health Professional Hong Kong
Primary
Concomitant
Histiocytic Medullary Reticulosis Other Serious 3/15/2010 59 Male 165 lb 6/29/2010 Physician United States
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 4/28/2010 43 Female 110 lb 7/2/2010 Physician Japan
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 1/1/2008 65 Female 150 lb 7/15/2010 Other Health Professional United States
Primary
Concomitant
Thrombocytopenic Purpura Other Serious 4/28/2010 43 Female 110 lb 7/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pustular Psoriasis Other Serious 5/14/2010 59 Female 157 lb 7/23/2010 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 7/3/2010 64 Male 149 lb 7/23/2010 Physician Japan
Primary
Concomitant
Gait Disturbance Other Serious 6/1/2010 41 Female 126 lb 7/28/2010 Physician Brazil
Primary
Secondary
Concomitant
Gait Disturbance Other Serious 6/1/2010 41 Female 126 lb 8/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Menorrhagia Other Serious 11/25/2008 40 Female 126 lb 8/5/2010 Physician Brazil
Primary
Secondary
Concomitant
Menorrhagia Other Serious 6/1/2010 41 Female 126 lb 8/11/2010 Physician Brazil
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/1/2009 13 Male 8/12/2010 Physician Chile
Primary
Concomitant
Hiatus Hernia Hospitalization 6/1/2010 57 Female 8/12/2010 Other Health Professional Colombia
Primary
Concomitant
Pyrexia Hospitalization 4/3/2009 18 Female 8/13/2010 Other Health Professional Japan
Primary
Concomitant
Chest X-ray Abnormal Hospitalization 7/1/2010 79 Female 8/13/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 4/28/2010 43 Female 110 lb 8/20/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Chlamydial Other Serious 7/3/2010 64 Male 149 lb 8/23/2010 Physician Japan
Primary
Concomitant
Optic Neuritis Other Serious 8/3/2010 67 Female 180 lb 8/24/2010 Other Health Professional United States
Primary
Concomitant
Menorrhagia Other Serious 11/25/2008 40 Female 126 lb 8/30/2010 Physician Brazil
Primary
Secondary
Concomitant
Vertigo Hospitalization 2/27/2010 60 Female 132 lb 8/30/2010 Physician Japan
Primary
Concomitant
Sinusitis Hospitalization 5/26/2010 57 Female 191 lb 9/1/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 7/22/2010 70 Female 157 lb 9/1/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 8/8/2010 47 Female 110 lb 9/2/2010 Consumer Peru
Primary
Concomitant
Menorrhagia Other Serious 6/1/2010 41 Female 126 lb 9/3/2010 Physician Brazil
Primary
Secondary
Concomitant
Optic Neuritis Disability 8/3/2010 67 Female 180 lb 9/4/2010 Other Health Professional United States
Primary
Concomitant
Pyrexia Hospitalization 4/3/2009 18 Female 9/8/2010 Other Health Professional Japan
Primary
Concomitant
Renal Impairment Other Serious 7/1/2010 79 Female 9/8/2010 Physician Japan
Primary
Secondary
Concomitant
Menorrhagia Other Serious 11/25/2008 40 Female 126 lb 9/13/2010 Physician Brazil
Primary
Secondary
Concomitant
Mesothelioma Other Serious 3/15/2010 61 Male 9/13/2010 Physician Switzerland
Primary
Concomitant
Chills 8/13/2010 51 Female 120 lb 9/15/2010 Physician Hong Kong
Primary
Concomitant
Rheumatoid Arthritis Other Serious 9/3/2010 81 Female 105 lb 9/17/2010 Consumer United States
Primary
Concomitant
Menorrhagia Other Serious 6/1/2010 41 Female 126 lb 9/17/2010 Physician Brazil
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 6/1/2008 51 Female 9/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Hospitalization 9/21/2010 43 Female 9/28/2010 Other Health Professional Colombia
Primary
Concomitant
Optic Neuritis Disability 8/2/2010 67 Female 180 lb 9/29/2010 Other Health Professional United States
Primary
Concomitant
Renal Failure Other Serious 8/1/2010 79 Female 9/30/2010 Physician Japan
Primary
Secondary
Concomitant
Leukopenia Hospitalization 9/17/2010 63 Female 9/30/2010 Other Health Professional Colombia
Primary
Concomitant
Tachycardia Other Serious 8/1/2010 19 Male 55 lb 10/6/2010 Consumer Lebanon
Primary
Concomitant
Subarachnoid Haemorrhage Disability 6/7/2010 49 Female 10/7/2010 Physician Japan
Primary
Concomitant
Reflux Oesophagitis Hospitalization 9/24/2009 57 Female 115 lb 10/8/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Low Density Lipoprotein Increased Life Threatening 4/14/2010 53 Female 128 lb 10/8/2010 Physician Japan
Primary
Secondary
Concomitant
Sapho Syndrome Hospitalization 4/1/2010 57 Female 117 lb 10/11/2010 Physician Japan
Primary
Concomitant
Thyroid Neoplasm Other Serious Male 238 lb 10/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Polypectomy Hospitalization 6/1/2009 10/25/2010 Physician Germany
Primary
Concomitant
Deep Vein Thrombosis Other Serious 10/12/2010 59 Male 10/26/2010 Other Health Professional Australia
Primary
Concomitant
Reflux Oesophagitis Hospitalization 9/24/2009 57 Female 115 lb 10/29/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 10/20/2010 67 Female 103 lb 11/1/2010 Consumer United States
Primary
Concomitant
Oedema Peripheral Other Serious 10/20/2010 67 Female 103 lb 11/12/2010 Consumer United States
Primary
Concomitant
Oedema Hospitalization 9/8/2010 53 Male 11/15/2010 Other Health Professional Colombia
Primary
Concomitant
Viith Nerve Paralysis Other Serious 40 Female 227 lb 11/17/2010 Physician Pakistan
Primary
Concomitant
Rash Hospitalization 9/21/2010 43 Female 11/19/2010 Consumer Colombia
Primary
Concomitant
Hypertension Hospitalization 9/21/2010 43 Female 11/22/2010 Consumer Colombia
Primary
Concomitant
Pancreatitis Other Serious Female 11/23/2010 Physician Australia
Primary
Concomitant
Pancreatitis Hospitalization 8/31/2010 28 Female 11/24/2010 Physician Argentina
Primary
Concomitant
Viith Nerve Paralysis Other Serious 40 Female 227 lb 11/29/2010 Physician Pakistan
Primary
Concomitant
Transmission Of An Infectious Agent Via A Medicinal Product Other Serious 1/1/2010 61 Female 121 lb 11/29/2010 Consumer Kazakhstan
Primary
Concomitant
Thrombotic Cerebral Infarction Hospitalization 55 Female 11/29/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 10/2/2010 53 Female 141 lb 12/3/2010 Consumer United States
Primary
Concomitant
Hemiplegia Other Serious 9/9/2010 73 Male 157 lb 12/3/2010 Physician Australia
Primary
Secondary
Concomitant
Sapho Syndrome Hospitalization 5/12/2010 57 Female 117 lb 12/3/2010 Physician Japan
Primary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization 10/19/2010 80 Female 12/6/2010 Physician Japan
Primary
Concomitant
Pneumonia Disability Male 12/15/2010 Other Health Professional Australia
Primary
Concomitant
Rheumatoid Arthritis Other Serious 11/29/2010 71 Female 126 lb 12/20/2010 Consumer United States
Primary
Concomitant
Oral Mucosal Eruption Hospitalization 8/1/2010 63 Female 12/20/2010 Consumer Colombia
Primary
Concomitant
Pneumonia Other Serious 7/1/2010 68 Male 143 lb 12/21/2010 Other Health Professional Australia
Primary
Concomitant
Oral Mucosal Eruption Hospitalization 8/1/2010 63 Female 12/27/2010 Consumer Colombia
Primary
Concomitant
Lower Gastrointestinal Haemorrhage Hospitalization 10/19/2010 80 Female 130 lb 12/29/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 12/12/2010 47 Male 12/30/2010 Other Health Professional Colombia
Primary
Concomitant
Pyrexia Other Serious 11/25/2010 9 Male 47 lb 1/12/2011 Consumer United States
Primary
Concomitant
Joint Swelling Other Serious 11/29/2010 72 Female 126 lb 1/14/2011 Consumer United States
Primary
Concomitant
Diverticular Perforation Other Serious 10/2/2010 53 Female 141 lb 1/18/2011 Physician United States
Primary
Concomitant
Dyspnoea Other Serious 10/20/2010 67 Female 103 lb 1/18/2011 Physician United States
Primary
Concomitant
Knee Arthroplasty Other Serious 1/1/2009 58 Female 1/21/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Disability 6/7/2010 49 Female 115 lb 1/24/2011 Physician Japan
Primary
Concomitant
Cholelithiasis Hospitalization 10/2/2010 53 Female 141 lb 1/26/2011 Consumer United States
Primary
Concomitant
Subcutaneous Haematoma Hospitalization 12/8/2010 77 Male 1/27/2011 Other Health Professional Japan
Primary
Concomitant
Dyspnoea Other Serious 11/11/2010 18 Female 304 lb 2/2/2011 Physician United States
Primary
Concomitant
Dyspnoea Hospitalization 12/10/2010 44 Female 228 lb 1/24/2011 Pharmacist United States
Primary
Concomitant
Headache Other Serious 11/11/2010 18 Female 304 lb 2/8/2011 Physician United States
Primary
Concomitant
Cerebrovascular Accident Other Serious 11/17/2010 62 Female 216 lb 2/9/2011 Physician United States
Primary
Concomitant
Drug Eruption Hospitalization 12/8/2010 77 Male 170 lb 2/9/2011 Physician Japan
Primary
Concomitant
Portal Vein Thrombosis Hospitalization Female 154 lb 2/9/2011 Consumer United States
Primary
Concomitant
Drug Eruption Hospitalization 12/8/2010 77 Male 170 lb 2/11/2011 Other Health Professional Japan
Primary
Concomitant
Cerebrovascular Accident Other Serious 11/17/2010 62 Female 216 lb 2/11/2011 Physician United States
Primary
Concomitant
Vomiting Other Serious 11/11/2010 18 Female 304 lb 2/11/2011 Physician United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization Female 154 lb 2/11/2011 Consumer United States
Primary
Concomitant
Pain Other Serious 1/4/2011 12 Female 55 lb 2/11/2011 Physician Saudi Arabia
Primary
Concomitant
Mesenteric Artery Thrombosis Disability Female 154 lb 2/17/2011 Consumer United States
Primary
Concomitant
Feeling Of Despair Hospitalization 1/22/2011 44 Female 170 lb 2/18/2011 Consumer Brazil
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 1/12/2011 65 Female 132 lb 2/18/2011 Physician Israel
Primary
Concomitant
Embolism Arterial Hospitalization 2/6/2011 41 Female 161 lb 2/25/2011 Physician United States
Primary
Concomitant
Depression Hospitalization 1/22/2011 44 Female 2/25/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Polyneuropathy Other Serious 6/1/2010 68 Female 2/28/2011 Physician Brazil
Primary
Concomitant
Breast Cancer Stage Iv Life Threatening 11/16/2010 54 Female 110 lb 3/1/2011 Physician Japan
Primary
Concomitant
Hormone Level Abnormal Hospitalization 1/22/2011 70 Male 3/10/2011 Consumer Russian Federation
Primary
Concomitant
Pulmonary Embolism Life Threatening 2/6/2011 41 Female 161 lb 3/11/2011 Other Health Professional United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Hospitalization 1/22/2011 70 Male 3/11/2011 Consumer Russian Federation
Primary
Concomitant
Headache Other Serious Female 3/11/2011 Other Health Professional Australia
Primary
Concomitant
Atrophic Glossitis Other Serious 2/23/2011 31 Female 104 lb 3/14/2011 Physician Japan
Primary
Concomitant
Oropharyngeal Pain Other Serious Female 3/15/2011 Other Health Professional Australia
Primary
Concomitant
Nervous System Disorder Other Serious 62 Female 3/16/2011 Physician Switzerland
Primary
Secondary
Cholelithiasis Hospitalization 7/7/2010 53 Female 141 lb 3/18/2011 Consumer United States
Primary
Concomitant
Malaise Hospitalization 9/1/2010 72 Female 120 lb 3/28/2011 Consumer United States
Primary
Secondary
Concomitant
Aortitis Hospitalization 3/8/2011 34 Male 3/29/2011 Other Health Professional Japan
Primary
Concomitant
Leukopenia Other Serious 1/22/2011 69 Male 159 lb 3/30/2011 Physician Russian Federation
Primary
Concomitant
Chills Other Serious Female 3/30/2011 Other Health Professional Australia
Primary
Concomitant
Dyspnoea Other Serious 12/10/2010 44 Female 228 lb 3/14/2011 Pharmacist United States
Primary
Concomitant
Abortion Spontaneous Other Serious 1/1/2010 30 Female 205 lb 4/6/2011 Physician United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 1/1/2009 10 Male 4/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Respiratory Tract Congestion Male 168 lb 4/8/2011 Consumer Australia
Primary
Concomitant
Back Pain Other Serious 2/22/2011 41 Female 190 lb 4/8/2011 Consumer United States
Primary
Concomitant
Eructation Other Serious 3/21/2011 49 Female 154 lb 4/11/2011 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2011 78 Male 217 lb 4/13/2011 Consumer United States
Primary
Concomitant
Rash Macular Hospitalization 8/1/2010 57 Female 128 lb 4/14/2011 Consumer Brazil
Primary
Secondary
Concomitant
Face Oedema Other Serious Female 4/15/2011 Other Health Professional Australia
Primary
Concomitant
Infusion Related Reaction Disability 8/23/2010 61 Female 160 lb 4/5/2011 Physician United States
Primary
Concomitant

Drug Data