Actemra combined with Alendronate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Hypoaesthesia Hospitalization 8/1/2008 60 Female 9/8/2008 Consumer Japan
Primary
Concomitant
Pain In Extremity Hospitalization 8/4/2008 60 Female 117 lb 10/14/2008 Consumer Japan
Primary
Secondary
Concomitant
Pulmonary Hypertension Other Serious 10/21/2009 Female 152 lb 1/28/2010 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Other Serious 10/21/2009 Female 152 lb 2/1/2010 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Other Serious 10/21/2009 Female 152 lb 2/10/2010 Physician Japan
Primary
Concomitant
Peritonitis Hospitalization 2/20/2010 Male 3/15/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 2/20/2010 Male 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Death 2/20/2010 50 Male 157 lb 4/5/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 5/3/2006 38 Male 157 lb 4/6/2010 Physician Japan
Primary
Concomitant
Shock Hospitalization 2/24/2010 74 Female 97 lb 4/9/2010 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Other Serious 10/21/2009 54 Female 152 lb 4/13/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 5/15/2009 58 Female 4/15/2010 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 5/3/2006 38 Male 157 lb 4/23/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 5/15/2009 58 Female 4/23/2010 Physician Japan
Primary
Concomitant
Erythema Multiforme Hospitalization 4/7/2010 64 Female 86 lb 5/28/2010 Physician Japan
Primary
Secondary
Pulmonary Hypertension Other Serious 10/21/2009 54 Female 152 lb 6/22/2010 Physician Japan
Primary
Concomitant
Erythema Multiforme Hospitalization 4/7/2010 64 Female 86 lb 7/8/2010 Physician Japan
Primary
Secondary
Menorrhagia Other Serious 11/25/2008 40 Female 126 lb 8/30/2010 Physician Brazil
Primary
Secondary
Concomitant
Menorrhagia Other Serious 6/1/2010 41 Female 126 lb 9/3/2010 Physician Brazil
Primary
Secondary
Concomitant
Menorrhagia Other Serious 11/25/2008 40 Female 126 lb 9/13/2010 Physician Brazil
Primary
Secondary
Concomitant
Menorrhagia Other Serious 6/1/2010 41 Female 126 lb 9/17/2010 Physician Brazil
Primary
Secondary
Concomitant
Bronchopneumonia Death 1/1/2010 50 Male 157 lb 4/22/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Patella Fracture Hospitalization 12/16/2009 64 Female 82 lb 6/3/2011 Physician Japan
Primary
Concomitant
Pleurisy Hospitalization 6/1/2011 65 Female 97 lb 7/18/2011 Other Health Professional Japan
Primary
Concomitant
Infection Death 5/13/2011 67 Female 99 lb 8/4/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 5/1/2010 64 Female 110 lb 8/5/2011 Other Health Professional Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 3/5/2010 63 Female 117 lb 8/15/2011 Physician Japan
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 6/24/2011 59 Female 8/17/2011 Physician France
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 5/1/2010 64 Female 110 lb 8/18/2011 Other Health Professional Japan
Primary
Concomitant
Blood Blister Other Serious 5/1/2010 64 Female 110 lb 9/12/2011 Other Health Professional Japan
Primary
Concomitant
Alanine Aminotransferase Increased Hospitalization 9/10/2008 55 Female 9/13/2011 Physician Japan
Primary
Secondary
Concomitant
Pyelonephritis Acute Other Serious 6/18/2011 56 Female 97 lb 9/22/2011 Other Health Professional Japan
Primary
Concomitant
Organising Pneumonia Hospitalization 3/1/2010 63 Female 117 lb 9/23/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 5/17/2010 50 Male 159 lb 10/6/2011 Physician France
Primary
Secondary
Concomitant
Acute Respiratory Failure Hospitalization 7/13/2011 52 Female 10/11/2011 Other Health Professional Italy
Primary
Concomitant
Arthritis Bacterial Life Threatening 4/17/2009 76 Female 10/13/2011 Japan
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 10/4/2008 68 Female 10/14/2011 Physician Japan
Primary
Concomitant
Cellulitis Death 5/13/2011 67 Female 99 lb 10/14/2011 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/2/2010 54 Female 143 lb 10/17/2011 Japan
Primary
Concomitant
Ivth Nerve Paralysis Hospitalization 9/10/2008 55 Female 10/17/2011 Physician Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 9/3/2011 38 Female 132 lb 10/18/2011 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 12/16/2009 64 Female 82 lb 10/18/2011 Japan
Primary
Concomitant
Malaise Hospitalization 9/3/2011 38 Female 132 lb 10/21/2011 Japan
Primary
Concomitant
Cholelithiasis Other Serious Female 10/21/2011 Physician Japan
Primary
Concomitant
Cholelithiasis Other Serious Female 10/27/2011 Japan
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Female 152 lb 11/1/2011 Consumer Brazil
Primary
Concomitant
Diarrhoea Other Serious 7/1/2011 48 Male 108 lb 11/4/2011 Physician Japan
Primary
Secondary
Concomitant
Haemoptysis Other Serious 2/19/2009 76 Female 11/7/2011 Physician Japan
Primary
Concomitant
Gynaecomastia Other Serious 1/1/2008 56 Male 11/9/2011 Italy
Primary
Concomitant
Skin Ulcer Hospitalization 5/1/2010 64 Female 110 lb 11/9/2011 Physician Japan
Primary
Concomitant
Viral Infection Hospitalization 12/2/2010 54 Female 143 lb 11/14/2011 Physician Japan
Primary
Concomitant
Gastric Ulcer Hospitalization 4/17/2009 76 Female 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Gynaecomastia Other Serious 10/28/2011 60 Male 11/22/2011 Italy
Primary
Concomitant
Myocardial Infarction Other Serious 9/28/2011 Female 183 lb 11/24/2011 Physician Germany
Primary
Concomitant
Dermal Cyst Hospitalization 4/1/2004 63 Male 11/30/2011 Japan
Primary
Secondary
Concomitant
Myocardial Infarction Death 11/28/2011 29 Female 12/6/2011 Czech Republic
Primary
Concomitant
Pyrexia Hospitalization 3/1/2010 70 Female 86 lb 12/8/2011 Japan
Primary
Secondary
Concomitant
Subcutaneous Abscess Hospitalization 10/19/2011 61 Female 132 lb 12/9/2011 Physician Japan
Primary
Secondary
Concomitant
Cholelithiasis Other Serious Female 12/9/2011 Japan
Primary
Concomitant
Lumbar Spinal Stenosis Other Serious 2/19/2009 76 Female 12/14/2011 Physician Japan
Primary
Concomitant
Osteoarthritis Hospitalization 11/29/2011 68 Female 143 lb 12/20/2011 Physician Germany
Primary
Concomitant
Arthritis Bacterial Life Threatening 4/17/2009 76 Female 12/20/2011 Japan
Primary
Secondary
Concomitant
Myelocytosis Other Serious 4/5/2011 44 Female 12/22/2011 Physician France
Primary
Concomitant
Gingivitis Other Serious 12/29/2010 69 Female 12/23/2011 Physician Japan
Primary
Secondary
Concomitant
Ovarian Neoplasm Hospitalization 12/15/2011 53 Female 119 lb 12/23/2011 Physician Japan
Primary
Secondary
Ovarian Neoplasm Hospitalization 12/15/2011 53 Female 119 lb 12/29/2011 Physician Japan
Primary
Secondary
Varicose Vein Ruptured Hospitalization 3/7/2009 62 Male 209 lb 12/29/2011 Japan
Primary
Concomitant
Pyelonephritis Acute Hospitalization 6/18/2011 56 Female 97 lb 1/2/2012 Physician Japan
Primary
Concomitant
Pleural Effusion Death 3/1/2010 70 Female 86 lb 1/2/2012 Physician Japan
Primary
Secondary
Concomitant
Cholecystitis Acute Hospitalization 3/5/2009 64 Male 121 lb 1/2/2012 Japan
Primary
Secondary
Concomitant
Lung Infection Pseudomonal Life Threatening 6/1/2011 65 Female 88 lb 1/3/2012 Physician Japan
Primary
Concomitant
Bronchitis Other Serious 3/24/2009 70 Female 99 lb 1/3/2012 Japan
Primary
Secondary
Concomitant
Haemoptysis Hospitalization 5/6/2010 70 Female 1/3/2012 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Nodule Hospitalization 9/9/2010 75 Female 126 lb 1/4/2012 Physician Germany
Primary
Concomitant
Ocular Icterus Hospitalization 4/21/2009 72 Female 110 lb 1/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Ovarian Neoplasm Hospitalization 12/15/2011 53 Female 119 lb 1/17/2012 Japan
Primary
Secondary
Thrombocytopenia Hospitalization 2/6/2009 63 Female 1/17/2012 Physician Japan
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 5/17/2010 50 Male 159 lb 1/25/2012 Physician France
Primary
Secondary
Concomitant
Arthralgia Hospitalization 1/17/2012 40 Male 200 lb 1/26/2012 Pharmacist Canada
Primary
Concomitant
Pleurisy Hospitalization 6/1/2011 65 Female 88 lb 1/26/2012 Japan
Primary
Concomitant
Pneumonia Pneumococcal Other Serious 4/21/2009 72 Female 110 lb 1/30/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Pleurisy Hospitalization 6/1/2011 65 Female 88 lb 2/1/2012 Physician Japan
Primary
Concomitant
Infected Dermal Cyst Hospitalization 1/1/2011 69 Female 112 lb 2/2/2012 Physician Japan
Primary
Concomitant
Anaemia Life Threatening 1/6/2012 76 Female 84 lb 2/6/2012 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 2/3/2012 71 Female 130 lb 2/10/2012 Other Health Professional Canada
Primary
Concomitant
Rheumatoid Arthritis Other Serious 2/3/2012 71 Female 130 lb 2/13/2012 Canada
Primary
Concomitant
Neurogenic Bladder Hospitalization 1/1/2011 69 Female 112 lb 2/15/2012 Physician Japan
Primary
Concomitant
Autoimmune Hepatitis Hospitalization 6/4/2010 65 Female 2/16/2012 Japan
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 1/1/2009 56 Female 2/17/2012 Physician Japan
Primary
Secondary
Concomitant
Hyperlipidaemia Hospitalization 8/24/2009 62 Female 2/23/2012 Physician Japan
Primary
Secondary
Concomitant
Ovarian Cancer Hospitalization 12/15/2011 53 Female 119 lb 2/23/2012 Physician Japan
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Death 4/21/2009 72 Female 110 lb 3/6/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Anaemia Life Threatening 1/6/2012 76 Female 84 lb 3/7/2012 Consumer Japan
Primary
Secondary
Concomitant
Spinal Compression Fracture Hospitalization 1/18/2010 61 Female 3/12/2012 Japan
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 3/24/2009 70 Female 99 lb 3/16/2012 Physician Japan
Primary
Secondary
Concomitant
Shock Death Female 3/26/2012 Physician Japan
Primary
Concomitant
Surgery Other Serious 1/1/2010 59 Male 3/29/2012 Japan
Primary
Concomitant
Cellulitis Life Threatening 2/1/2012 61 Female 3/29/2012 Consumer Japan
Primary
Concomitant
Behcet's Syndrome Hospitalization 7/1/2011 6 Male 42 lb 3/30/2012 Japan
Primary
Concomitant
Diverticulum Intestinal Life Threatening 3/19/2012 61 Female 119 lb 4/2/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 9/11/2010 69 Female 126 lb 4/6/2012 Physician Japan
Primary
Concomitant
Behcet's Syndrome Hospitalization 7/1/2011 6 Male 42 lb 4/6/2012 Japan
Primary
Concomitant
Nausea Hospitalization 7/30/2010 79 Female 4/9/2012 Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 2/3/2012 71 Female 130 lb 4/9/2012 Other Health Professional Canada
Primary
Concomitant
Alanine Aminotransferase Increased Other Serious 2/15/2010 47 Male 165 lb 4/11/2012 Physician Japan
Primary
Secondary
Concomitant
Arthritis Infective Hospitalization 1/1/2011 73 Female 123 lb 4/13/2012 Other Health Professional Canada
Primary
Concomitant
Spinal Compression Fracture Hospitalization 1/18/2010 61 Female 4/13/2012 Physician Japan
Primary
Concomitant
Benign Ovarian Tumour Other Serious 7/1/2011 64 Female 103 lb 4/16/2012 Physician Japan
Primary
Secondary
Concomitant
Abscess Intestinal Hospitalization 12/27/2011 75 Female 106 lb 4/17/2012 Physician Japan
Primary
Secondary
Concomitant
Diverticulitis Intestinal Haemorrhagic Hospitalization 8/24/2009 62 Female 4/17/2012 Japan
Primary
Secondary
Concomitant
Surgery Other Serious 1/1/2010 59 Male 4/24/2012 Japan
Primary
Concomitant
Gingivitis Hospitalization 2/8/2010 44 Male 126 lb 4/26/2012 Japan
Primary
Secondary
Concomitant
Erythema Hospitalization 10/12/2008 49 Male 5/2/2012 Physician Japan
Primary
Concomitant
Benign Ovarian Tumour Other Serious 7/1/2011 64 Female 103 lb 5/7/2012 Japan
Primary
Secondary
Concomitant
Meningioma Hospitalization 2/8/2010 44 Male 126 lb 5/7/2012 Japan
Primary
Secondary
Concomitant
Rheumatoid Nodule Hospitalization 9/9/2010 75 Female 126 lb 5/11/2012 Physician Germany
Primary
Concomitant
Lip And/or Oral Cavity Cancer Death 3/3/2011 60 Female 5/17/2012 Japan
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 9/2/2011 54 Male 170 lb 5/17/2012 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 3/14/2012 Female 5/18/2012 Physician France
Primary
Concomitant
Septic Shock Hospitalization 3/19/2012 61 Female 119 lb 5/21/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 1/1/2012 71 Female 130 lb 5/22/2012 Other Health Professional Canada
Primary
Concomitant
Pulmonary Oedema Hospitalization 5/14/2012 70 Female 148 lb 5/24/2012 Consumer Canada
Primary
Concomitant
Pneumonia Hospitalization 5/14/2012 70 Female 148 lb 5/29/2012 Consumer Canada
Primary
Concomitant
Cerebral Haemorrhage Other Serious Female 5/31/2012 Physician Japan
Primary
Concomitant
Atrial Fibrillation Other Serious 3/1/2012 78 Male 236 lb 5/31/2012 Consumer Canada
Primary
Concomitant
Seasonal Allergy Hospitalization 6/19/2010 33 Female 5/31/2012 Physician Japan
Primary
Secondary
Concomitant
Rib Fracture Hospitalization 1/1/2009 53 Male 6/5/2012 Physician Japan
Primary
Concomitant
Thermal Burn Death 8/16/2011 64 Female 110 lb 6/5/2012 Physician Japan
Primary
Secondary
Concomitant
Proteinuria Disability 9/30/2011 65 Female 154 lb 6/11/2012 Physician Slovenia
Primary
Concomitant
Erythema 10/12/2008 49 Male 6/13/2012 Japan
Primary
Concomitant
Cerebral Haemorrhage Other Serious Female 6/13/2012 Physician Japan
Primary
Concomitant
Conjunctivitis Other Serious 12/21/2011 72 Male 170 lb 6/14/2012 Physician Germany
Primary
Concomitant
Lung Infection Pseudomonal Hospitalization 2/25/2010 75 Female 6/18/2012 Japan
Primary
Secondary
Concomitant
Cerebral Ischaemia Death 8/21/2010 Female 172 lb 6/20/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Ileal Perforation Hospitalization 3/30/2012 75 Male 101 lb 6/21/2012 Physician Japan
Primary
Secondary
Concomitant
Vision Blurred Disability 1/20/2012 75 Female 216 lb 6/25/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Bronchopneumopathy Other Serious 12/16/2006 79 Male 194 lb 6/26/2012 France
Primary
Concomitant
Protein Urine Present Hospitalization 5/3/2006 38 Male 157 lb 6/28/2012 Physician Japan
Primary
Concomitant
Synovial Cyst Other Serious 1/1/2012 64 Female 132 lb 6/29/2012 Pharmacist Germany
Primary
Concomitant
Pancytopenia Hospitalization 6/7/2010 61 Female 132 lb 7/2/2012 Physician Japan
Primary
Concomitant
Ascites Hospitalization 7/1/2011 64 Female 103 lb 7/5/2012 Japan
Primary
Secondary
Concomitant
Eosinophil Count Increased Death 8/30/2011 79 Female 7/6/2012 Physician Japan
Primary
Secondary
Concomitant
Small Intestinal Obstruction Life Threatening 6/15/2012 62 Female 149 lb 7/9/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Encephalitis Autoimmune Death 7/1/2010 62 Male 141 lb 7/10/2012 Physician Japan
Primary
Concomitant
Superior Vena Cava Syndrome Life Threatening 8/3/2011 44 Female 7/11/2012 Physician Japan
Primary
Concomitant
Hyponatraemia Death 3/3/2012 83 Female 99 lb 7/13/2012 Japan
Primary
Concomitant
Hypercholesterolaemia Hospitalization 4/11/2012 71 Female 143 lb 7/17/2012 Physician Germany
Primary
Concomitant
Liver Abscess Life Threatening 4/17/2012 56 Female 124 lb 7/17/2012 Physician Singapore
Primary
Secondary
Concomitant
Meningitis Other Serious 4/17/2012 56 Female 124 lb 7/18/2012 Physician Singapore
Primary
Secondary
Concomitant
Pancytopenia Other Serious 6/7/2010 61 Female 132 lb 7/23/2012 Physician Japan
Primary
Secondary
Concomitant

Drug Data