Acetaminophen combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/23/2006 United States
Primary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 2/24/2006 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 8/1/2001 76 Female 99 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Hypertension Other Serious 2/15/2006 59 Male 220 lb 3/7/2006 United Kingdom
Primary
Concomitant
Swelling Face Other Serious 3/20/2005 72 Male 278 lb 12/21/2005 Consumer United States
Primary
Concomitant
Troponin T Increased Hospitalization 3/2/2005 77 Male 134 lb 3/22/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypertension Other Serious 2/15/2006 59 Male 220 lb 3/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rectal Haemorrhage Hospitalization 12/9/2005 76 Female 183 lb 4/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Surgery Hospitalization 2/1/2003 55 Male 4/27/2006 Physician Norway
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 6/22/2005 45 Female 150 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Retinal Artery Embolism Hospitalization 4/27/2004 74 Female 4/28/2006 Norway
Primary
Concomitant
White Blood Cell Count Decreased Death 7/30/2005 66 Male 203 lb 5/3/2006 Other Health Professional Hungary
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 12/22/2005 87 Male 5/1/2006 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 1/7/2004 50 Female 5/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Enterococcal Life Threatening 12/22/2005 87 Male 5/10/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Nausea Hospitalization 9/26/2004 65 Female 370 lb 5/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Tract Infection Enterococcal Life Threatening 12/22/2005 87 Male 5/19/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Large Intestinal Ulcer Other Serious 4/5/2006 50 Male 218 lb 4/7/2006 Pharmacist United States
Primary
Concomitant
Hyponatraemia Hospitalization 2/25/2005 78 Female 176 lb 5/25/2006 Physician Finland
Primary
Concomitant
Urinary Tract Infection Life Threatening 12/22/2005 87 Male 5/26/2006 United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Enterococcal Life Threatening 12/22/2005 87 Male 6/7/2006 United Kingdom
Primary
Secondary
Concomitant
Hallucination Hospitalization 11/1/2001 74 Male 6/23/2006 Other Health Professional Sweden
Primary
Concomitant
Multi-organ Failure Other Serious 7/2/2006 77 Female 99 lb 7/21/2006 Physician United Kingdom
Primary
Concomitant
Subdural Haemorrhage Death 7/23/2004 Female 143 lb 8/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vascular Dementia Hospitalization 7/6/2006 74 Male 170 lb 9/15/2006 Physician Netherlands
Primary
Concomitant
Muscle Haemorrhage Death 7/1/2006 78 Male 132 lb 10/6/2006 Physician Portugal
Primary
Concomitant
Syncope Vasovagal Hospitalization 7/9/2005 63 Female 234 lb 10/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 67 Female 162 lb 1/30/2006 Physician United States
Primary
Concomitant
Po2 Decreased Life Threatening 7/21/2006 70 Female 10/12/2006 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Required Intervention 8/23/2006 85 Male 160 lb 10/10/2006 Other Health Professional United States
Primary
Concomitant
Vascular Dementia Hospitalization 7/6/2006 74 Male 170 lb 10/17/2006 Physician Netherlands
Primary
Concomitant
Musculoskeletal Disorder Other Serious 12/1/2005 Male 10/30/2006 Other Health Professional Sweden
Primary
Concomitant
Pollakiuria Other Serious 7/1/2006 65 Female 88 lb 10/17/2006 Physician United Kingdom
Primary
Concomitant
Tibia Fracture Hospitalization 1/20/2006 56 Male 194 lb 11/9/2006 Physician United Kingdom
Primary
Concomitant
Rash Erythematous Other Serious 10/6/2006 62 Female 198 lb 11/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Erythematous Disability 10/6/2006 62 Female 198 lb 11/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 11/2/2006 48 Female 11/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 8/10/2006 75 Male 231 lb 11/21/2006 Pharmacist United States
Primary
Secondary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 91 12/6/2006 Physician Israel
Primary
Secondary
Concomitant
Skin Reaction Other Serious 10/6/2006 62 Female 198 lb 11/27/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Lung Infiltration Life Threatening 9/7/2006 Female 12/7/2006 Physician Finland
Primary
Concomitant
Pulmonary Tuberculosis Life Threatening 9/7/2006 Female 12/15/2006 Physician Finland
Primary
Concomitant
Renal Failure Acute Hospitalization 11/5/2006 80 Female 132 lb 12/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Tuberculosis Life Threatening 9/7/2006 Female 12/20/2006 Physician Finland
Primary
Concomitant
Otorrhoea Hospitalization 7/9/2005 Female 234 lb 12/29/2006 Physician United Kingdom
Primary
Concomitant
Nausea Other Serious 11/14/2006 71 Female 1/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 8/23/2006 52 Male 329 lb 10/13/2006 Pharmacist United States
Primary
Concomitant
Otorrhoea Hospitalization 7/7/2005 Female 234 lb 2/2/2007 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 11/13/2006 89 Male 121 lb 2/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 9/13/2006 75 Male 231 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/26/2007 82 Female 2/20/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Femur Fracture Other Serious 10/15/2005 Female 3/2/2007 Other Health Professional Sweden
Primary
Concomitant
Tardive Dyskinesia Other Serious 1/1/1999 72 Male 3/9/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Epilepsy Other Serious 2/22/2007 89 Female 124 lb 3/23/2007 Consumer United Kingdom
Primary
Concomitant
Liver Function Test Abnormal Other Serious 2/24/2007 72 Male 3/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Melaena Hospitalization 1/22/2007 61 Male 3/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 3/23/2007 72 Male 4/10/2007 Physician United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 3/23/2007 72 Male 4/16/2007 United Kingdom
Primary
Concomitant
Vomiting Required Intervention 3/6/2007 62 4/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Ventricular Tachycardia Hospitalization 5/23/2007 72 Male 6/4/2007 United Kingdom
Primary
Concomitant
Pancytopenia Required Intervention 2/20/2007 80 Male 131 lb 6/20/2007 Pharmacist United States
Primary
Concomitant
Orthostatic Hypotension Hospitalization 5/1/2007 90 Female 9/6/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/1999 72 Male 11/6/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Abdominal Wall Abscess Hospitalization 3/29/2007 Female 134 lb 12/28/2007 United Kingdom
Primary
Concomitant
Speech Disorder Other Serious 10/31/2007 Male 196 lb 12/28/2007 Physician United Kingdom
Primary
Concomitant
Chest Pain Other Serious 9/15/2007 Female 73 lb 1/22/2008 United Kingdom
Primary
Concomitant
Seizure Anoxic Hospitalization 12/4/2007 87 Male 3/18/2008 Other Health Professional Sweden
Primary
Concomitant
Peritonitis Hospitalization 3/15/2008 71 Male 201 lb 4/10/2008 Physician United States
Primary
Concomitant
Disease Progression Death 69 Female 208 lb 5/2/2008 Consumer United Kingdom
Primary
Concomitant
Cardio-respiratory Arrest Death 69 Female 4/30/2008 United Kingdom
Primary
Concomitant
Vomiting Other Serious 1/14/2004 50 Female 5/9/2008 United Kingdom
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 4/10/2008 69 Female 208 lb 4/29/2008 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 5/15/2008 United States
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 12/1/2006 88 Female 5/7/2008 Other Health Professional Finland
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 5/23/2008 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 5/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 5/7/2008 62 Female 6/6/2008 Sweden
Primary
Concomitant
Polyneuropathy Other Serious 60 Male 5/30/2008 Physician Sweden
Primary
Concomitant
Vomiting Other Serious 1/14/2004 50 Female 6/18/2008 United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 6/10/2008
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 8/30/2005 Male 139 lb 6/27/2008 United States
Primary
Concomitant
Haematuria Other Serious 6/3/2003 Male 7/7/2008 Other Health Professional Sweden
Primary
Concomitant
Interacting
Nausea Hospitalization 1/2/2008 Female 7/23/2008 Other Health Professional Sweden
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/1999 Male 7/29/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 6/1/2008 75 Male 161 lb 8/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/1999 Male 8/8/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 2/28/2008 89 Male 6/10/2008
Primary
Secondary
Concomitant
Somnolence Hospitalization 6/1/2008 Female 8/15/2008 Other Health Professional France
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 8/9/2008 United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 6/2/2008 55 Male 194 lb 7/30/2008 Pharmacist United States
Primary
Concomitant
Multiple Myeloma Other Serious Male 304 lb 9/5/2008 Consumer United Kingdom
Primary
Concomitant
Dehydration Hospitalization 8/20/2008 Female 199 lb 9/10/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 2/6/2008 51 Male 9/17/2008 Lawyer United States
Primary
Concomitant
Dehydration Hospitalization 8/20/2008 Female 199 lb 9/19/2008 Consumer United States
Primary
Secondary
Concomitant
Palpitations Other Serious 64 Female 9/19/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sciatica Other Serious 8/7/2007 74 Female 198 lb 10/10/2008 Physician Australia
Primary
Concomitant
Myocardial Infarction Other Serious 1/1/2005 61 Male 10/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Palpitations Disability 9/2/2008 63 Male 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Testicular Swelling Other Serious 10/1/2008 82 Male 132 lb 11/10/2008 Consumer Israel
Primary
Concomitant
Testicular Swelling Other Serious 10/1/2008 82 Male 132 lb 11/21/2008 Consumer Israel
Primary
Concomitant
Hypomagnesaemia Other Serious Female 12/5/2008 Physician United Kingdom
Primary
Concomitant
Renal Failure Chronic Life Threatening 5/13/2008 Female 241 lb 12/16/2008 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 11/1/2008 89 Female 141 lb 12/18/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 12/23/2008 Physician Spain
Primary
Concomitant
Troponin Increased Other Serious 1/1/2003 78 Male 140 lb 1/8/2009 United States
Primary
Concomitant
Pain Hospitalization 11/1/2008 74 Female 1/14/2009 Consumer United Kingdom
Primary
Secondary
Tendon Rupture Death 1/1/2008 91 Male 1/19/2009 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Other Serious 10/1/2008 Male 152 lb 1/20/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 1/28/2009 Physician Spain
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 44 Male 2/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Tendon Rupture Hospitalization 1/1/2008 91 Male 2/20/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 3/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 3/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 44 Male 360 lb 3/13/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Chest Pain Hospitalization 3/14/2009 4/2/2009 Physician Taiwan, Province Of China
Primary
Concomitant
Troponin Increased Other Serious 1/1/2003 78 Male 140 lb 4/14/2009 United States
Primary
Concomitant
Chest Pain Hospitalization 3/14/2009 4/15/2009 Physician Taiwan, Province Of China
Primary
Concomitant
Vomiting Hospitalization 71 Male 196 lb 4/23/2009 Other Health Professional United Kingdom
Primary
Concomitant
Chest Pain Hospitalization 3/14/2009 4/24/2009 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Supraventricular Tachyarrhythmia Life Threatening 3/26/2009 Male 5/15/2009 Consumer United Kingdom
Primary
Concomitant
Chest Pain Hospitalization 3/14/2009 73 6/9/2009 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 362 lb 7/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 7/2/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 7/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 10/1/2008 53 Male 247 lb 7/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 362 lb 7/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hand Deformity Other Serious 4/1/2009 Male 7/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Death 2/18/2009 Female 183 lb 8/21/2009 United Kingdom
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 3/10/1998 54 Male 209 lb 9/23/2009 United States
Primary
Concomitant
International Normalised Ratio Increased Life Threatening 8/4/2009 84 Female 10/13/2009 United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Life Threatening 8/4/2009 84 Female 10/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 10/28/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Congestive Death 6/6/2009 Male 10/29/2009 Physician United Kingdom
Primary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 10/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 11/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 11/19/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Peritonitis Bacterial Other Serious 3/5/2009 76 Male 168 lb 11/3/2009 Other Health Professional United States
Primary
Concomitant
Dyspnoea Life Threatening 11/21/2009 Male 161 lb 12/14/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/16/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/23/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/28/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/29/2009 Physician India
Primary
Secondary
Concomitant

Drug Data