Acenocoumarol combined with Digoxin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Failure Other Serious 9/1/2005 78 Male 1/19/2006 Physician Netherlands
Primary
Secondary
Concomitant
Hyperaldosteronism Hospitalization 12/28/2004 73 Female 121 lb 2/3/2006 Consumer France
Primary
Secondary
Concomitant
Gynaecomastia Hospitalization 1/1/1998 90 Male 2/7/2006 Consumer Greece
Primary
Concomitant
Gynaecomastia Hospitalization 1/1/1998 90 Male 2/13/2006 Consumer Greece
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 3/31/2006 68 Male 216 lb 4/14/2006 Physician Greece
Primary
Concomitant
Staphylococcal Sepsis Other Serious 1/21/2006 81 Female 4/28/2006 Physician Spain
Primary
Concomitant
Oesophagitis Hospitalization 3/31/2006 68 Male 216 lb 5/11/2006 Physician Greece
Primary
Concomitant
Hyperphosphataemia Other Serious 4/20/2006 Female 5/11/2006 Physician Spain
Primary
Concomitant
Hyperphosphataemia Hospitalization 4/20/2006 Female 5/12/2006 Physician Spain
Primary
Concomitant
Hyperphosphataemia Hospitalization 4/20/2006 Female 5/22/2006 Physician Spain
Primary
Concomitant
Hyperphosphataemia Other Serious 4/20/2006 Female 5/22/2006 Physician Spain
Primary
Concomitant
Haemolytic Anaemia Hospitalization 4/16/2006 76 Female 123 lb 6/7/2006 Other Health Professional France
Primary
Concomitant
Pallor Hospitalization 4/16/2006 76 Female 123 lb 7/12/2006 Other Health Professional France
Primary
Concomitant
Rhabdomyolysis Other Serious 34 Male 7/21/2006 Other Health Professional Spain
Primary
Concomitant
Renal Failure Hospitalization 10/15/2005 79 Female 10/27/2006 Other Health Professional Argentina
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/18/2006 62 Male 12/6/2006 Physician Spain
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 9/17/2006 81 Female 12/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 11/18/2006 62 Male 187 lb 12/18/2006 Physician Spain
Primary
Secondary
Speech Disorder Hospitalization 12/1/2006 19 Female 101 lb 1/26/2007 Physician Spain
Primary
Concomitant
Speech Disorder Other Serious 12/1/2006 19 Female 101 lb 3/8/2007 Physician Spain
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 9/17/2006 81 Female 3/26/2007 Other Health Professional France
Primary
Secondary
Concomitant
Speech Disorder Other Serious 12/1/2006 19 Female 101 lb 3/29/2007 Physician Spain
Primary
Concomitant
Orthostatic Hypotension Hospitalization 5/17/2004 78 Female 4/5/2007 Other Health Professional Spain
Primary
Secondary
Concomitant
Vertigo Other Serious 42 Male 4/27/2007 Physician France
Primary
Concomitant
Myocardial Infarction Other Serious 4/9/2007 42 Male 4/27/2007 Physician France
Primary
Concomitant
Skin Hyperpigmentation Other Serious 70 Male 5/1/2007 Other Health Professional Greece
Primary
Concomitant
Toxic Skin Eruption Hospitalization 2/26/2007 77 Female 5/10/2007 Other Health Professional France
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 2/1/2006 81 Male 5/31/2007 Physician Greece
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 3/1/2007 Female 5/25/2007 France
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 4/19/2007 71 Male 6/20/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Interacting
Urine Amylase Increased Death 7/1/2006 71 Female 7/3/2007 Physician Spain
Primary
Concomitant
Toxic Skin Eruption Hospitalization 2/26/2007 77 Female 7/5/2007 Other Health Professional France
Primary
Secondary
Concomitant
Urine Amylase Increased Death 7/1/2006 71 Female 7/13/2007 Physician Spain
Primary
Concomitant
Pain In Extremity Hospitalization 6/26/2007 73 Female 7/30/2007 Spain
Primary
Concomitant
Pain In Extremity Hospitalization 6/16/2007 73 Female 8/16/2007 Spain
Primary
Concomitant
Nausea Other Serious 1/15/2007 68 Male 8/30/2007 Physician Spain
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 10/31/2007 Other Health Professional Spain
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 9/20/2007 84 Female 11/8/2007 Other Health Professional France
Primary
Secondary
Hypercalcaemia Other Serious 10/30/2007 Female 200 lb 12/19/2007 Greece
Primary
Concomitant
Osteonecrosis Other Serious 5/1/2007 61 Female 1/8/2008 Physician Netherlands
Primary
Concomitant
Syncope Other Serious 1/1/2007 91 Male 1/30/2008 Netherlands
Primary
Secondary
Concomitant
Hypercalcaemia Other Serious 10/30/2007 Female 200 lb 2/8/2008 Greece
Primary
Concomitant
Tuberculosis Other Serious 7/19/2004 Female 163 lb 3/5/2008 United Kingdom
Primary
Concomitant
Cardiac Disorder Other Serious 4/16/2007 Male 3/26/2008 Physician Netherlands
Primary
Concomitant
Visual Disturbance Hospitalization 1/1/2004 Female 6/13/2008 France
Primary
Concomitant
Venous Insufficiency Hospitalization 5/1/2008 88 Male 7/9/2008 Physician France
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 3/28/2008 Female 163 lb 8/13/2008 United Kingdom
Primary
Concomitant
Tremor Other Serious 1/1/2007 73 Male 154 lb 8/21/2008 Physician Greece
Primary
Secondary
Concomitant
Death Death 8/29/2008 Male 163 lb 9/18/2008 Physician Netherlands
Primary
Concomitant
Hyperkalaemia Death 91 Male 9/24/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 10/9/2008 Consumer Spain
Primary
Concomitant
Hyperkalaemia Death 91 Male 10/15/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Syncope Hospitalization 91 Male 10/16/2008 Consumer Netherlands
Primary
Secondary
Concomitant
Renal Failure Other Serious 9/1/2007 91 Male 10/24/2008 Netherlands
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 11/17/2006 72 Female 165 lb 10/27/2008 Physician Netherlands
Primary
Secondary
Concomitant
Phaehyphomycosis Hospitalization 1/1/2003 81 Female 10/27/2008
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 8/29/2008 Male 163 lb 11/19/2008 Physician Netherlands
Primary
Concomitant
Syncope Hospitalization 10/3/2008 66 Male 186 lb 12/2/2008 Greece
Primary
Concomitant
Vomiting Hospitalization 4/1/2008 81 Female 12/23/2008 Physician Spain
Primary
Concomitant
Medication Error Death 9/1/2007 91 Male 1/8/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Renal Impairment Other Serious 91 Male 1/13/2009
Primary
Secondary
Cardiac Failure Death 12/24/2008 1/16/2009 Physician India
Primary
Concomitant
Ventricular Tachycardia Life Threatening 1/23/2009 Other Health Professional Italy
Primary
Secondary
Vomiting Hospitalization 4/1/2008 81 Female 1/28/2009 Physician Spain
Primary
Concomitant
Cardiac Failure Death 12/24/2008 2/23/2009 Physician India
Primary
Concomitant
Tendon Rupture Disability 12/25/2006 57 Male 3/10/2009 France
Primary
Secondary
Hepatotoxicity Other Serious 83 Male 3/26/2009 Other Health Professional Germany
Primary
Concomitant
Urinary Retention Other Serious 10/27/1993 13 Male 4/2/2009 Other Health Professional France
Primary
Secondary
Serum Ferritin Increased Other Serious 83 Male 4/22/2009 Other Health Professional Germany
Primary
Concomitant
Liver Injury Other Serious 83 Male 4/23/2009 Other Health Professional Spain
Primary
Concomitant
Septic Shock Hospitalization 3/15/2009 80 Female 4/23/2009 Physician Switzerland
Primary
Secondary
Concomitant
Liver Injury Other Serious 83 Male 4/28/2009 Other Health Professional Spain
Primary
Concomitant
Weight Decreased Other Serious 83 Male 5/5/2009
Primary
Concomitant
Liver Injury Other Serious 83 Male 5/7/2009 United States
Primary
Concomitant
Treatment Failure Hospitalization 91 Male 5/15/2009 Netherlands
Primary
Secondary
Concomitant
Lupus-like Syndrome Hospitalization Female 6/24/2009 Other Health Professional France
Primary
Concomitant
Wound Treatment Hospitalization 3/18/2009 Female 6/25/2009 Consumer Mexico
Primary
Concomitant
Wound Treatment Hospitalization 3/12/2009 Female 6/30/2009 Consumer Mexico
Primary
Concomitant
Vomiting Other Serious 4/1/2008 81 Female 7/8/2009 Physician Spain
Primary
Concomitant
Venous Insufficiency Hospitalization 5/1/2008 88 Male 7/13/2009 Physician France
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2008 81 Female 7/24/2009 Physician Spain
Primary
Concomitant
Neurotoxicity Hospitalization 69 Female 137 lb 8/31/2009 Other Health Professional Netherlands
Primary
Concomitant
Ventricular Tachycardia Required Intervention 2/24/2007 72 Female 11/3/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Weight Decreased Other Serious 83 Male 12/2/2009 Other Health Professional Spain
Primary
Concomitant
Urinary Incontinence Hospitalization 2/6/2010 Male 231 lb 2/19/2010 Physician Romania
Primary
Secondary
Concomitant
Renal Failure Hospitalization 73 Female 2/19/2010 Consumer United Kingdom
Primary
Concomitant
Urinary Incontinence Hospitalization 2/6/2010 Male 231 lb 2/23/2010 Physician Romania
Primary
Secondary
Concomitant
Vomiting Other Serious 73 Female 2/16/2010
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 11/9/2009 Male 176 lb 3/3/2010 Netherlands
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 12/18/2009 87 Female 3/4/2010 Physician Switzerland
Primary
Concomitant
Ventricular Arrhythmia Other Serious 75 Male 3/9/2010 Other Health Professional Netherlands
Primary
Secondary
Urinary Incontinence Hospitalization 2/6/2010 Male 231 lb 3/19/2010 Physician Romania
Primary
Secondary
Concomitant
Renal Failure Hospitalization 75 Male 3/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Urinary Incontinence Hospitalization 2/6/2010 Male 231 lb 3/25/2010 Physician Romania
Primary
Secondary
Concomitant
Hepatic Cirrhosis Other Serious Male 4/13/2010 Pharmacist Netherlands
Primary
Concomitant
Myalgia Hospitalization 4/1/2010 Female 5/3/2010 Consumer Belgium
Primary
Concomitant
Ventricular Arrhythmia Other Serious 75 Male 5/4/2010 Other Health Professional Netherlands
Primary
Secondary
Off Label Use Hospitalization Male 187 lb 5/5/2010 Pharmacist Netherlands
Primary
Concomitant
Urinary Tract Disorder Other Serious 3/29/2010 85 Female 130 lb 5/14/2010 Physician
Primary
Concomitant
Renal Failure Hospitalization 75 Male 5/18/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Ventricular Arrhythmia Other Serious 75 Male 5/28/2010 Physician Netherlands
Primary
Interacting
Urinary Tract Disorder Other Serious 3/29/2010 85 Female 130 lb 6/7/2010 Physician
Primary
Concomitant
Urinary Tract Disorder Other Serious 3/29/2010 85 Female 130 lb 6/8/2010 Physician
Primary
Concomitant
Ventricular Arrhythmia Other Serious 75 Male 6/18/2010
Primary
Secondary
Renal Failure Hospitalization 75 Male 7/27/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Renal Failure Hospitalization 75 Male 7/27/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Renal Failure Hospitalization 75 Male 7/27/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Renal Failure Hospitalization 75 Male 7/27/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Renal Failure Hospitalization 75 Male 7/27/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Hyperkalaemia Hospitalization 3/18/2010 79 Male 7/29/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Failure Life Threatening 75 Male 7/28/2010
Primary
Secondary
Interacting
Renal Failure Other Serious 75 Male 8/2/2010 Other Health Professional Netherlands
Primary
Secondary
Wound Secretion Hospitalization 1/1/2008 87 Female 7/27/2010 Other Health Professional France
Primary
Concomitant
Ventricular Fibrillation Life Threatening 11/9/2009 75 Male 176 lb 8/4/2010 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Life Threatening 75 Male 8/4/2010 Netherlands
Primary
Interacting
Ventricular Tachycardia Other Serious Female 8/10/2010
Primary
Secondary
Ventricular Arrhythmia Life Threatening 75 Male 8/9/2010 Other Health Professional Netherlands
Primary
Secondary
Renal Failure Other Serious 75 Male 9/10/2010 Other Health Professional Netherlands
Primary
Secondary
Renal Failure Hospitalization 75 Male 9/10/2010 Other Health Professional Netherlands
Primary
Secondary
Interacting
Wound Secretion Hospitalization 1/1/2008 87 Female 9/16/2010 Other Health Professional France
Primary
Concomitant
Vision Blurred Other Serious 6/22/2009 82 Female 187 lb 10/6/2010 Other Health Professional Spain
Primary
Concomitant
Cardiovascular Disorder Other Serious 10/11/2010 Physician Spain
Primary
Secondary
Renal Failure Hospitalization 73 Female 10/15/2010 Other Health Professional Germany
Primary
Concomitant
Vision Blurred Other Serious 6/22/2009 82 Female 187 lb 10/19/2010 Other Health Professional Spain
Primary
Concomitant
Renal Failure Hospitalization 73 Female 10/22/2010 Other Health Professional Germany
Primary
Concomitant
Vision Blurred Other Serious 6/22/2009 82 Female 187 lb 10/22/2010 Other Health Professional Spain
Primary
Concomitant
Renal Failure Hospitalization 73 Female 11/12/2010 Other Health Professional Germany
Primary
Concomitant
Rectal Haemorrhage Hospitalization 10/23/2010 78 Male 12/3/2010 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Hospitalization 73 Female 12/6/2010 Other Health Professional Spain
Primary
Concomitant
Ventricular Arrhythmia Other Serious 75 Male 12/6/2010 Physician Netherlands
Primary
Interacting
Death Death 12/15/2010 Physician Spain
Primary
Secondary
Concomitant
Death Death 12/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Impairment Death 1/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Death Death 1/17/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Interaction Death 1/17/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Interaction Death 1/25/2011 Consumer Japan
Primary
Secondary
Concomitant
Right Ventricular Failure Death Male 154 lb 3/8/2011 Physician Hungary
Primary
Concomitant
Encephalopathy Death 2/1/2010 75 Male 3/10/2011 Other Health Professional Spain
Primary
Concomitant
Bradycardia Other Serious 12/20/2010 69 Male 3/18/2011 Physician Netherlands
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 12/28/2010 77 Female 3/21/2011 Physician Spain
Primary
Secondary
Concomitant
Bradycardia Hospitalization 12/20/2010 69 Male 4/1/2011 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 3/25/2011 4/8/2011 Physician Argentina
Primary
Concomitant
Ventricular Tachycardia Life Threatening 72 Female 4/14/2011 Other Health Professional United States
Primary
Secondary
Renal Failure Acute Other Serious 3/25/2011 65 Female 4/26/2011 Physician Argentina
Primary
Concomitant
Drug Interaction Hospitalization 8/2/2010 71 Female 5/19/2011 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 3/25/2011 65 Female 5/25/2011 Physician Argentina
Primary
Concomitant
Renal Failure Acute Other Serious 3/24/2011 Female 6/1/2011 Physician Argentina
Primary
Concomitant
Electrocardiogram Qt Prolonged Hospitalization 75 Male 6/6/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Hallucination Hospitalization 6/22/2009 82 Female 187 lb 6/22/2011 Other Health Professional Spain
Primary
Concomitant
Electrocardiogram Qt Prolonged Hospitalization 75 Male 6/10/2011 Physician Netherlands
Primary
Concomitant

Drug Data